Chronic Administration of Oil Palm (Elaeis guineensis) Leaves Extract Attenuates Hyperglycaemic-Induced Oxidative Stress and Improves Renal Histopathology and Function in Experimental Diabetes

Table 1

Effects of OPLE on body and kidney weights, random blood glucose level, and mean arterial pressure.

	Nondiabetic	Diabetic control	Diabetic + OPLE	Diabetic + OPLE
			200 mg kg^−1	500 mg kg^−1
	(4 week)	(4 week)	(4 week)	(4 week)
	(12 week)	(12 week)	(12 week)	(12 week)
Body weight g	365.0 ± 14.3	309.2 ± 25.4	303.3 ± 37.6	283.3 ± 17.2
	428.3 ± 13.0	235.0 ± 14.6^aaa	251.7 ± 17.2^aaa	289.2 ± 14.9^aaa
Kidney weight g 100 g^−1 body weight	0.40 ± 0.01	0.57 ± 0.03^aa	0.53 ± 0.04^a	0.59 ± 0.04^aa
	0.32 ± 0.02	0.69 ± 0.02^aaa	0.62 ± 0.04^aaa	0.59 ± 0.02^aaa
Glucose level mmol L^−1	4.7 ± 0.1	30.7 ± 1.7^aaa	32.2 ± 0.5^aaa	31.2 ± 2.1^aaa
	6.3 ± 0.2	31.0 ± 1.2^aaa	31.6 ± 1.1^aaa	33.1 ± 0.2^aaa
Mean arterial pressure mm Hg	113.2 ± 2.1	115.3 ± 3.2	109.3 ± 3.7	116.7 ± 1.9
	111.5 ± 2.9	116.7 ± 3.3	109.0 ± 5.3	112.2 ± 3.9

Data are expressed as mean ± SEM of six experiments for each group. ^a𝑃<0.05; ^aa𝑃<0.01; ^aaa𝑃<0.001 versus corresponding nondiabetic.