Chronic Administration of Oil Palm (Elaeis guineensis) Leaves Extract Attenuates Hyperglycaemic-Induced Oxidative Stress and Improves Renal Histopathology and Function in Experimental Diabetes
Table 1
Effects of OPLE on body and kidney weights, random blood glucose level, and mean arterial pressure.
Nondiabetic
Diabetic control
Diabetic + OPLE
Diabetic + OPLE
200 mg kg−1
500 mg kg−1
(4 week)
(4 week)
(4 week)
(4 week)
(12 week)
(12 week)
(12 week)
(12 week)
Body weight g
365.0 ± 14.3
309.2 ± 25.4
303.3 ± 37.6
283.3 ± 17.2
428.3 ± 13.0
235.0 ± 14.6aaa
251.7 ± 17.2aaa
289.2 ± 14.9aaa
Kidney weight g 100 g−1 body weight
0.40 ± 0.01
0.57 ± 0.03aa
0.53 ± 0.04a
0.59 ± 0.04aa
0.32 ± 0.02
0.69 ± 0.02aaa
0.62 ± 0.04aaa
0.59 ± 0.02aaa
Glucose level mmol L−1
4.7 ± 0.1
30.7 ± 1.7aaa
32.2 ± 0.5aaa
31.2 ± 2.1aaa
6.3 ± 0.2
31.0 ± 1.2aaa
31.6 ± 1.1aaa
33.1 ± 0.2aaa
Mean arterial pressure mm Hg
113.2 ± 2.1
115.3 ± 3.2
109.3 ± 3.7
116.7 ± 1.9
111.5 ± 2.9
116.7 ± 3.3
109.0 ± 5.3
112.2 ± 3.9
Data are expressed as mean ± SEM of six experiments for each group. a; aa; aaa versus corresponding nondiabetic.