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Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 196358, 9 pages
http://dx.doi.org/10.1155/2012/196358
Research Article

Long-Term Oral Administration of Capsicum baccatum Extracts Does Not Alter Behavioral, Hematological, and Metabolic Parameters in CF1 Mice

1Pharmaceutical Sciences Graduate Program, Faculty of Pharmacy, Federal University of Rio Grande do Sul (UFRGS), Ipiranga Avendia 2752, 90610-000 Porto Alegre, RS, Brazil
2Post-Graduate Program in Biological Science, Department of Biochemistry, ICBS, Federal University of Rio Grande do Sul (UFRGS), Ramiro Barcelos Street 2600, 90035-003 Porto Alegre, RS, Brazil

Received 13 August 2012; Revised 20 November 2012; Accepted 21 November 2012

Academic Editor: Jenny M. Wilkinson

Copyright © 2012 Aline Rigon Zimmer et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Our group showed that crude ethanol (CE) and butanol (BUT) extracts of Capsicum baccatum presented anti-inflammatory and antioxidant properties. Furthermore, the flavonoid and total phenolic contents were positively correlated with both of these properties observed for C. baccatum extracts. The present study demonstrated that 60 days of oral administration of CE and BUT (200 mg/kg) in mice did not cause significant differences in the following parameters evaluated: hematological profile, body weight and relative weight of visceral organs, systemic lipid profile, glucose homeostasis (GTT), kidney and hepatic biochemical markers, and spontaneous locomotion and anxiety-like behavior. Altogether, these results indicate for the first time that the long-term oral administration of C. baccatum extracts does not affect specific aspects of CF1 mice physiology, suggesting their safety, building up the venue to test their efficacy in animal models underlying persistent activation of oxidative and inflammatory pathways.