Network-Based Gene Expression Biomarkers for Cold and Heat Patterns of Rheumatoid Arthritis in Traditional Chinese Medicine

Figure 4

The PPI network of functional relationships between the cold and heat patterns. Diamonds represent seed nodes. Cycles represent neighbor nodes. All edges represent interactions. (a) Is the network specific to the cold pattern. (c) Is the network specific to the heat pattern. (b) Is the commonly shared network of both patterns, which is likely the common network of RA. The parts between (a) and (b) and between (b) and (c), as shown by arrows, are the connections between the highly condensed TCM pattern-related networks and the common shared network.