Network-Based Gene Expression Biomarkers for Cold and Heat Patterns of Rheumatoid Arthritis in Traditional Chinese Medicine

<table>The gene ontology relationship between the TCM cold and heat patterns in RA. Cycles on the left represent cold-pattern-related biological processes. Cycles on the right represent heat-pattern-related biological processes. Cycles in the middle represent the biological processes common to the cold and heat patterns. Arrows represent the direction of the regulation of differently expressed genes: up signifies up-regulation, and down signifies down-regulation.</table>

Evidence-Based Complementary and Alternative Medicine

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Figure 5

Figure 5: Network-Based Gene Expression Biomarkers for Cold and Heat Patterns of Rheumatoid Arthritis in Traditional Chinese Medicine 