Network-Based Gene Expression Biomarkers for Cold and Heat Patterns of Rheumatoid Arthritis in Traditional Chinese Medicine

Table 1

Differentially expressed genes in cold-pattern RA patient versus healthy control.

Gene name	Definition	Accession no.	Cold/control ratio
Upregulated gene (>1.4)
MMGT1	Membrane magnesium transporter 1	AL157477	1.70
TDRD7	Tudor domain containing 7	AB025254	1.56
SLC4A7	Solute carrier family 4, sodium bicarbonate Cotransporter, member 7	AF047033	1.54
MRPL28	Mitochondrial ribosomal protein L28	NM_006428	1.54
CCNT1	Cyclin T1	NM_001240	1.52
GTF3C6	General transcription factor IIIC, polypeptide 6, alpha 35 kDa	BC011593	1.49
BCL2A1	BCL2-related protein A1	NM_004049	1.45
TRIM22	Tripartite motif-containing 22	NM_006074	1.45
CTLA4	Cytotoxic T-lymphocyte-associated protein 4	AF414120	1.45
KLRAQ1	KLRAQ motif containing 1	BC011978	1.45
GBP3	Guanylate binding protein 3	AL136680	1.43
MIS12	MIS12, MIND kinetochore complex component, homolog (S. pombe)	NM_024039	1.43
PDCD2	Programmed cell death 2	AJ420535	1.43
ATOX1	ATX1 antioxidant protein 1 homolog (yeast)	NM_004045	1.43
PIGB	Phosphatidylinositol glycan, class B	NM_004855	1.41
NPEPPS	Aminopeptidase puromycin sensitive	NM_006310	1.41
Downregulated gene (<1 : 1.4)
Unknown	Homo sapiens cDNA FLJ11459 fis, clone HEMBA1001566	AK021521	0.59
Unknown	Homo sapiens mRNA; cDNA DKFZp434I138 (from clone DKFZp434I138)	AL122121	0.66
Unknown	Homo sapiens clone 24629 mRNA sequence	AF052160	0.66
ZNF330	Zinc finger protein 330	NM_014487	0.67
PLP2	Proteolipid protein 2 (colonic epithelium-enriched)	NM_002668	0.68
PTGES2	Prostaglandin E synthase 2	NM_025072	0.68
PSMD8	Proteasome (prosome, macropain) 26S subunit, non-ATPase, 8	NM_002812	0.68
IL7R	Interleukin 7 receptor	NM_002185	0.68
STMN3	Stathmin-like 3	NM_015894	0.68
ABCC10	ATP-binding cassette, sub-family C (CFTR/MRP), member 10	AK000002	0.69
ELAC2	ElaC homolog 2 (E. coli)	NM_018127	0.69
PLEKHA1	Pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 1	NM_021622	0.69
DCXR	Dicarbonyl/L-xylulose reductase	NM_016286	0.70
EIF4A2	Eukaryotic translation initiation factor 4A2	NM_001967	0.70
IL16	Interleukin 16 (lymphocyte chemoattractant factor)	M90391	0.70
GRAMD1B	GRAM domain containing 1B	AB033027	0.71
LAGE3	L antigen family, member 3	NM_006014	0.71
TMEM80	Transmembrane protein 80	BC008671	0.71
SLIT3	Slit homolog 3 (Drosophila)	AL122074	0.71