Network-Based Gene Expression Biomarkers for Cold and Heat Patterns of Rheumatoid Arthritis in Traditional Chinese Medicine

Table 10

The gene ontology analysis of the cold pattern versus control and the heat pattern versus control comparisons.

GO ID	Description	P value
	Cold pattern versus control
Subnetworks A
6455	Translational elongation	4.26E-168
6416	Translation	6.96E-146
44249	Cell biosynthetic process	1.87E-104
9059	Macromolecule biosynthetic	8.699E-70
10467	Gene expression	1.156E-68
Subnetworks B
31145	Anaphase-promoting complex-dependent proteasomal ubiquitin-depended protein catabolic process	4.326E-81
51436	Negative regulation of ubiquitin protein ligase activity during mitotic cell cycle	4.326E-81
51352	Negative regulation of ligase activity	1.235E-80
51444	Positive regulation of ligase activity during mitotic cell cycle	1.235E-80
51437	Positive regulation of ligase activity	9.253E-80
Subnetworks C
6374	Nuclear mRNA splicing, via spliceosome	9.582E-17
375	RNA splicing, via transesterification reactions	9.582E-17
377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9.582E-17
6395	RNA splicing	1.284E-14
6397	mRNA process	2.703E-14
Subnetworks D
7259	JAK-STAT cascade	2.231E-09
19221	Cytokine and chemokine mediated signaling pathway	1.603E-08
1553	Luteinization	5.211E-07
1779	Natural killer cell differentiation	5.211E-07
46544	Development of secondary male sexual characteristics	5.211E-07
	Heat pattern versus control
Subnetworks E
31145	Anaphase-promoting complex-dependent proteasomal ubiquitin-depended protein catabolic process	1.45E-105
51436	Negative regulation of ubiquitin protein ligase activity during mitotic cell cycle	1.45E-105
51352	Negative regulation of ligase activity	4.16E-105
51444	Positive regulation of ligase activity during mitotic cell cycle	4.16E-105
51437	Positive regulation of ligase activity	3.14E-104
Subnetworks F
51101	Regulation of DNA binding	1.508E-05
51098	Regulation of binding	3.286E-05
43123	Positive regulation of I-κB kinase/NF-κB cascade	5.187E-05
9607	Response to biotic stimulus	5.593E-05
43122	Regulation of I-κB kinase/NF-κB cascade	6.457E-05
Subnetworks G
6395	RNA splicing	1.284E-14
6397	mRNA splicing	2.703E-14
16071	mRNA metabolic process	7.908E-14
6394	RNA processing	1.458E-12
16070	RNA metabolic process	1.175E-10
Subnetworks H
6633	Fatty acid biosynthetic process	1.498E-09
46394	Carboxylic acid biosynthetic process	2.761E-09
16053	Organic acid biosynthetic process	2.761E-09
6631	Fatty acid metabolic process	7.384E-08
32787	Monocarboxylic acid metabolic process	2.767E-07