Network-Based Gene Expression Biomarkers for Cold and Heat Patterns of Rheumatoid Arthritis in Traditional Chinese Medicine

Table 2

Differentially expressed genes in heat-pattern RA patient versus healthy control.

Gene name	Definition	Accession no.	Heat/control ratio
Up-regulated gene (>1.4)
CAMP	Cathelicidin antimicrobial peptide	NM_004345	2.33
MMGT1	Membrane magnesium transporter 1	AL157477	1.69
TDRD7	Tudor domain containing 7	AB025254	1.56
LSM6	LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)	NM_007080	1.54
CCDC55	Coiled-coil domain containing 55	NM_032141	1.54
GTF3C6	General transcription factor IIIC, polypeptide 6, alpha 35 kDa	BC011593	1.54
CD59	CD59 molecule, complement regulatory protein	NM_000611	1.52
CTLA4	Cytotoxic T-lymphocyte-associated protein 4	AF414120	1.52
ASCC3	Activating signal cointegrator 1 complex subunit 3	AY013288	1.47
PRKAA1	Protein kinase, AMP-activated, alpha 1 catalytic subunit	AK024252	1.45
BCL2A1	BCL2-related protein A1	NM_004049	1.45
TMEM60	Transmembrane protein 60	NM_032936	1.43
HSPA1A	Heat shock 70 kD protein 1A	NM_005345	1.43
PARP9	Poly (ADP-ribose) polymerase family, member 9	NM_031458	1.43
HIST1H1C	histone cluster 1, H1c	NM_005319	1.43
Down-regulated gene (<1 : 1.4)
HSPA8	Heat shock 70 kD protein 8	NM_006597	0.63
SLC43A3	Solute carrier family 43, member 3	NM_014096	0.67
Unknown	Homo sapiens clone 24629 mRNA sequence	AF052160	0.67
PSMD8	Proteasome (prosome, macropain) 26S subunit, non-ATPase, 8	NM_002812	0.69
NCL	Nucleolin	NM_005381	0.70
LBH	Limb bud and heart development homolog (mouse)	NM_030915	0.71