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Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 236539, 12 pages
http://dx.doi.org/10.1155/2012/236539
Research Article

Sarcandra glabra Extract Reduces the Susceptibility and Severity of Influenza in Restraint-Stressed Mice

1Department of Medicine, Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou 510632, China
2Institute of Biomedical and Health Engineering, Translational Medicine Research and Development Center, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China
3State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
4Pharmacology Laboratory of Traditional Chinese Medicine, Guangdong Provincial Institute of Traditional Chinese Medicine, Guangzhou 510095, China

Received 5 July 2012; Revised 12 September 2012; Accepted 20 September 2012

Academic Editor: Seong-Gyu Ko

Copyright © 2012 Hui-Juan Cao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Sarcandra glabra, as a type of “antipyretic-detoxicate drugs”, has always been widely used in traditional Chinese medicine (TCM). The Sarcandra glabra extract (SGE) is applied frequently as anti-inflammatory and anti-infectious drug in folk medicine. However, relative experiment data supporting this effective clinical consequence was limited. In order to mimic the physiological conditions of the susceptible population, we employed restraint stress mouse model to investigate the effect of SGE against influenza. Mice were infected with influenza virus three days after restraint, while SGE was orally administrated for 10 consecutive days. Body weight, morbidity, and mortality were recorded daily. Histopathologic changes, susceptibility genes expressions and inflammatory markers in lungs were determined. Our results showed that restraint stress significantly increased susceptibility and severity of influenza virus. However, oral administration of SGE could reduce morbidity, mortality and significantly prolonged survival time. The results further showed that SGE had a crucial effect on improving susceptibility markers levels to recover the balance of host defense system and inhibiting inflammatory cytokines levels through down-regulation of NF- B protein expression to ameliorate the lung injury. These data showed that SGE reduced the susceptibility and severity of influenza.