JCM-16021, a Chinese Herbal Formula, Attenuated Visceral Hyperalgesia in TNBS-Induced Postinflammatory Irritable Bowel Syndrome through Reducing Colonic EC Cell Hyperplasia and Serotonin Availability in Rats

<table>Effects of JCM-16021 on enterochromaffin (EC) cell density and 5-HT content in the colon tissue of PI-IBS rats. (a) shows the representative EC cells (arrowhead) in colonic mucosa of the (A1) normal rats, (A2) PI-IBS rats, (A3) pCPA treated rats, and (A4) high dose JCM-16021 treated rats (Scale bar, 200 <i>μ</i>m). Statistical graph of EC cell density is shown in (b), and 5-HT content in (c). Data are presented as mean ± S.E.M., <svg height="10.925" id="M13" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 36.237499 10.925" width="36.237499" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> per group. <svg height="19.65" id="M14" style="vertical-align:-3.276pt" version="1.1" viewbox="0 0 70.224998 19.65" width="70.224998" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> versus PI-IBS rats (<i>t</i>-test).</table>

Evidence-Based Complementary and Alternative Medicine

fig2

Figure 2

Figure 2: JCM-16021, a Chinese Herbal Formula, Attenuated Visceral Hyperalgesia in TNBS-Induced Postinflammatory Irritable Bowel Syndrome through Reducing Colonic EC Cell Hyperplasia and Serotonin Availability in Rats 

Figure 2 | JCM-16021, a Chinese Herbal Formula, Attenuated Visceral Hyperalgesia in TNBS-Induced Postinflammatory Irritable Bowel Syndrome through Reducing Colonic EC Cell Hyperplasia and Serotonin Availability in Rats 