Table 4: Intent-to-treat and per-protocol analyses of main symptom score, minor symptom score, and cumulative symptom score.

Intent-to-treat analysisChange from baseline to day 4 (mean ± SD)
Group A (n = 114)Group B (n = 117)Group C (n = 115)

Main symptom score8.842 ± 3.4538.513 ± 3.0507.330 ± 4.209
 P value versus group C<0.0001<0.0001
Minor symptom score5.851 ± 2.8396.120 ± 2.4435.157 ± 2.648
 P value versus group C<0.0001<0.0001
Cumulative symptom score14.320 ± 5.57713.890 ± 4.94911.920 ± 6.090
 P value versus group C<0.0001<0.0001

Per-protocol analysisGroup A (n = 113)Group B (n = 113)Group C (n = 108)

Main symptom score8.920 ± 3.3658.522 ± 3.0947.417 ± 4.212
 P value versus group C<0.0001<0.0001
Minor symptom score5.876 ± 2.8386.053 ± 2.3945.241 ± 2.696
 P value versus group C<0.0001<0.0001
Cumulative symptom score14.420 ± 5.49813.850 ± 5.01612.060 ± 6.143
 P value versus group C<0.0001<0.0001