Table 1: Summary of rat model histopathological scores.

Factor (scores)DMNDMN + GPDMN + SilymarinGPControl
1-2 wk3-4 wk5-6 wk2 wk3-4 wk5-6 wk2 wk3-4 wk5-6 wk2–6 wk1–6 wk
n (%)n (%)n (%)n (%)n (%)n (%)n(%)n (%)n (%)n (%)n (%)

NecroinflammatoryA00 (0)1 (9)4 (44)3 (50)4 (45)9 (64)0 (0)2 (22)2 (20)10 (100)100 (24)
A (1–3)5 (62.5)3 (27)4 (44)3 (50)2 (22)1 (7)3 (75)3 (33)2 (20)0 (0)0 (0)
A (4–6)3 (36.5)7 (64)1 (12)0 (0)3 (33)4 (29)1 (25)4 (45)6 (60)0 (0)0 (0)

FibrosisF (0-1)6 (75)1 (9)2 (22)6 (100)8 (67)7 (50)3 (75)3 (33)0 (0)10 (100)100 (24)
F (2-3)2 (25)10 (91)7 (78)0 (0)4 (33)7 (50)1 (25)6 (67)10 (100)0 (0)0 (0)

Fatty change7 (87.5)11 (100)9 (100)6 (100)12 (100)14 (100)4 (100)8 (89)10 (100)10 (100)100 (24)
+1 (12.5)0 (0)0 (0)0 (0)0 (0)0 (0)0 (0)1 (11)0 (0)0 (0)0 (0)

Results are ranked by time course. Necroinflammatory change was scored as A (0), no change; A (1–3), mild; A (4–6), moderate necroinflammation. Fibrosis was graded as F (0-1) for observations ranging from normal tissue to fibrous expansion of portal tracts and F (2-3) for bridge fibrosis to frequent bridging fibrosis with nodule formation. The fatty change was classified by its presence or absence (+/−). The number of rats was counted and used to calculate the percentage of each histopathological level at each time point.
n: number of rats.