Table 1: Summary of rat model histopathological scores.

Factor (scores) DMN DMN + GP DMN + Silymarin GP Control 1-2 wk 3-4 wk 5-6 wk 2 wk 3-4 wk 5-6 wk 2 wk 3-4 wk 5-6 wk 2–6 wk 1–6 wk n (%) n (%) n (%) n (%) n (%) n (%) n(%) n (%) n (%) n (%) n (%) Necroinflammatory A0 0 (0) 1 (9) 4 (44) 3 (50) 4 (45) 9 (64) 0 (0) 2 (22) 2 (20) 10 (100) 100 (24) A (1–3) 5 (62.5) 3 (27) 4 (44) 3 (50) 2 (22) 1 (7) 3 (75) 3 (33) 2 (20) 0 (0) 0 (0) A (4–6) 3 (36.5) 7 (64) 1 (12) 0 (0) 3 (33) 4 (29) 1 (25) 4 (45) 6 (60) 0 (0) 0 (0) Fibrosis F (0-1) 6 (75) 1 (9) 2 (22) 6 (100) 8 (67) 7 (50) 3 (75) 3 (33) 0 (0) 10 (100) 100 (24) F (2-3) 2 (25) 10 (91) 7 (78) 0 (0) 4 (33) 7 (50) 1 (25) 6 (67) 10 (100) 0 (0) 0 (0) Fatty change − 7 (87.5) 11 (100) 9 (100) 6 (100) 12 (100) 14 (100) 4 (100) 8 (89) 10 (100) 10 (100) 100 (24) + 1 (12.5) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 1 (11) 0 (0) 0 (0) 0 (0)

Results are ranked by time course. Necroinflammatory change was scored as A (0), no change; A (1–3), mild; A (4–6), moderate necroinflammation. Fibrosis was graded as F (0-1) for observations ranging from normal tissue to fibrous expansion of portal tracts and F (2-3) for bridge fibrosis to frequent bridging fibrosis with nodule formation. The fatty change was classified by its presence or absence (+/−). The number of rats was counted and used to calculate the percentage of each histopathological level at each time point. n: number of rats.