Evaluation of the Chinese Medicinal Herb, Graptopetalum paraguayense, as a Therapeutic Treatment for Liver Damage in Rat Models
Table 2
Therapeutic effects of Graptopetalum paraguayense (GP) on DMN-induced liver fibrosis in rats via biochemical analysis (1).
Categorical variable
Numeric variable
DMN
DMN + GP
Control (n)a
1st to 2nd wk (n)b
3rd to 4th wk (n)b
5th to 6th wk (n)b
2nd wk (n)c
3rd to 4th wk (n)c
5th to 6th wk (n)c
Albumin (g/dL)
4.6 ± 0.3 (23)
3.9 ± 0.7 (07)
3.5 ± 0.6 (11)
3.2 ± 0.1 (07)
3.7 ± 0.5 (06)
4.0 ± 0.7 (12)
4.3 ± 0.6 (14)
GPT (U/L)
58.8 ± 19.6 (23)
459.5 ± 78.5 (08)
566.6 ± 313.5 (11)
763.6 ± 405.2 (07)
235.0 ± 128.6 (06)
207.0 ± 111.7 (12)
262.5 ± 386.2 (14)
GOT (U/L)
101.9 ± 30.4 (23)
661.5 ± 134.4 (08)
1006.1 ± 749.6 (11)
1572.9 ± 965.3 (07)
271.3 ± 106.0 (06)
190.4 ± 114.5 (12)
218.0 ± 259.6 (14)
Bilirubin (mg/dL)
0.11 ± 0.04 (24)
0.72 ± 0.53 (08)
1.00 ± 0.74 (11)
1.13 ± 1.00 (07)
0.25 ± 0.14 (06)
0.25 ± 0.20 (12)
0.3 ± 0.32 (14)
AKP (KA)
45.9 ± 7.5 (12)
600.8 ± 93.0 (04)
668.3 ± 222.0 (03)
468 ± 12.7 (02)
298.2 ± 65.8 (04)
353.3 ± 62.3 (08)
374.0 ± 88.3 (11)
LDH (IU/L)
280.5 ± 49.0 (11)
414.8 ± 102.7 (04)
562.0 ± 120.8 (03)
853.5 ± 91.2 (02)
352.0 ± 21.9 (04)
378.6 ± 36.1 (08)
329.5 ± 67.6 (11)
Globulin (g/dL)
7.0 ± 0.4 (11)
6.65 ± 0.1 (02)
5.0 ± 0.84 (04)
3.6 ± 03 (02)
5.9 ± 0.6 (04)
5.7 ± 0.5 (08)
5.9 ± 1.0 (11)
Triglyceride (mg/dL)
148.0 ± 33.7 (12)
151.3 ± 107.3 (04)
180.9 ± 144.4 (07)
102.8 ± 35.1 (05)
73.0 ± 26.9 (02)
96.5 ± 29.9 (08)
98.3 ± 32.2 (11)
AFP (ng/dL)
0.26 ± 0.06 (10)
0.40 ± 0.19 (04)
0.38 ± 0.05 (04)
0.35 ± 0.07 (02)
0.20 ± 0.00 (02)
0.28 ± 0.13 (08)
0.26 ± 0.08 (10)
CHOL (mg/dL)
83.2 ± 0.14.1 (12)
76.5 ± 7.9 (04)
69.5 ± 12.8 (06)
66.6 ± 17.5 (05)
60.0 ± 5.0 (04)
65.9 ± 15.5 (08)
70.8 ± 18.6 (11)
BUN (mg/dL)
27.2 ± 6.0 (12)
32.5 ± 3.9 (04)
36.25 ± 2.2 (04)
30.5 ± 4.9 (02)
18.8 ± 3.9 (04)
20.9 ± 2.2 (08)
30.6 ± 23.0 (11)
ACP (mg/dL)
2.4 ± 0.6 (12)
1.9 ± 0.6 (04)
6.2 ± 1.1 (04)
8.2 ± 0.6 (02)
3.8 ± 0.6 (04)
5.0 ± 1.5 (08)
3.7 ± 1.1 (11)
PT (sec)
13.1 ± 1.1 (22)
18.5 ± 4.0 (08)
19.7 ± 4.3 (09)
21.5 ± 4.6 (06)
16.1 ± 2.6 (06)
17.2 ± 5.4 (10)
16.3 ± 2.9 (13)
PLT (103/mL)
871.5 ± 191.8 (24)
406.6 ± 71.7 (07)
300.2 ± 164.7 (11)
228.6 ± 302.4 (07)
535.3 ± 137.9 (06)
548.9 ± 259.1 (12)
704.5 ± 301.1 (14)
a: Mean ± SD of value from 1st to 6th week in control groups.
b: Mean ± SD of value from 1st to 2nd, 3rd to 4th or 5th to 6th week in DMN treatment groups.
c: Mean ± SD of value from 2nd, 3rd to 4th or 5th to 6th week in DMN+GP treatment groups. n: number of rats.
