Hypoglycemic and Hypolipidemic Effects of Ethanolic Extract of Mirabilis jalapa L. Root on Normal and Diabetic Mice

Table 1

Effects of single and repeated EEM administration on serum insulin level and ISI in normal and diabetic mice.

Group	Single administration		Repeated administration
	Serum insulin (mU/L)	ISI	Serum insulin (mU/L)	ISI
Normal control	11.80±0.83	−1.88±0.06	11.49±1.17	−1.85±0.04
Normal + 2 g/kg EEM	11.65±0.44	−1.88±0.04	11.68±0.60	−1.87±0.04
Normal + 4 g/kg EEM	11.60±0.79	−1.86±0.06	11.55±0.63	−1.86±0.05
Normal + 8 g/kg EEM	11.06±0.30	−1.86±0.05	11.67±0.64	−1.86±0.05
Normal + glibenclamide	11.91±0.36	−1.89±0.04	11.54±0.75	−1.85±0.06
Diabetic control	16.74±0.53 *	−2.45±0.05 *	14.81±1.04 *	−2.48±0.05 *
Diabetic + 2 g/kg EEM	16.43±0.43	−2.44±0.05	14.65±1.88	−2.48±0.08
Diabetic + 4 g/kg EEM	16.01±0.53	−2.43±0.03	11.88±0.90	−2.04±0.08^#
Diabetic + 8 g/kg EEM	16.07±0.95	−2.42±0.04	11.68±0.81	−2.03±0.05^#
Diabetic + glibenclamide	36.83±4.82^#	−2.40±0.09	39.15±6.55^#	−2.42±0.09

Insulin sensitivity index (ISI) = log (1/fasting plasma glucose × serum insulin). Data are expressed as mean ± SD, 𝑛=10 mice per group. *𝑃<0.01 when compared to normal control. ^#𝑃<0.01 when compared to diabetic control.