- About this Journal ·
- Abstracting and Indexing ·
- Advance Access ·
- Aims and Scope ·
- Annual Issues ·
- Article Processing Charges ·
- Articles in Press ·
- Author Guidelines ·
- Bibliographic Information ·
- Citations to this Journal ·
- Contact Information ·
- Editorial Board ·
- Editorial Workflow ·
- Free eTOC Alerts ·
- Publication Ethics ·
- Reviewers Acknowledgment ·
- Submit a Manuscript ·
- Subscription Information ·
- Table of Contents
Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 260301, 10 pages
Dose-Dependent Effects of the Cimicifuga racemosa Extract Ze 450 in the Treatment of Climacteric Complaints: A Randomized, Placebo-Controlled Study
1Institute for Health Care and Science, 35625 Hüttenberg, Germany
2Institute of Complementary Medicine, University Hospital Zurich (UHZ), 8091 Zurich, Switzerland
3Brunner & Hess, 8038 Zurich, Switzerland
4Clinic for Psychiatry and Psychotherapy, UHZ, 8091 Zurich, Switzerland
5Max Zeller Söhne AG, 8590 Romanshorn, Switzerland
Received 10 August 2012; Accepted 7 October 2012
Academic Editor: Bernhard Uehleke
Copyright © 2012 Ruediger Schellenberg et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- L. Dennerstein, J. Guthrie, M. Birkhäuser, et al., “Symptoms of the menopause,” in International Position Paper on Women's Health and Menopause: A Comprehensive Approach, N. K. Wenger, C. J. M. Lenfant, R. Paoletti, and V. W. Pinn, Eds., NIH Publication 02-3284, National Heart, Lung, and Blood Institute, Office of Research in Woman's Health, 2002.
- R. Green and N. Santoro, “Menopausal symptoms and ethnicity: the Study of Women's Health Across the Nation,” Women's Health, vol. 5, no. 2, pp. 127–133, 2009.
- R. C. Thurston and H. Joffe, “Vasomotor symptoms and menopause: findings from the study of women's health across the nation,” Obstetrics and Gynecology Clinics of North America, vol. 38, no. 3, pp. 489–501, 2011.
- F. Kronenberg, “Hot flashes: epidemiology and physiology,” Annals of the New York Academy of Sciences, vol. 592, pp. 52–86, 1990.
- K. Nakano, E. Pinnow, J. A. Flaws, J. D. Sorkin, and L. Gallicchio, “Reproductive history and hot flashes in perimenopausal women,” Journal of Women's Health, vol. 21, no. 4, pp. 433–439, 2012.
- M. S. Hunter, A. Gentry-Maharaj, A. Ryan et al., “Prevalence, frequency and problem rating of hot flushes persist in older postmenopausal women: Impact of age, body mass index, hysterectomy, hormone therapy use, lifestyle and mood in a cross-sectional cohort study of 10 418 British women aged 54–65,” An International Journal of Obstetrics and Gynaecology, vol. 119, no. 1, pp. 40–50, 2012.
- H. Joffe, C. N. Soares, and L. S. Cohen, “Assessment and treatment of hot flushes and menopausal mood disturbance,” Psychiatric Clinics of North America, vol. 26, no. 3, pp. 563–580, 2003.
- M. M. Ohayon, “Severe hot flashes are associated with chronic insomnia,” Archives of Internal Medicine, vol. 166, no. 12, pp. 1262–1268, 2006.
- A. MacLennan, S. Lester, and V. Moore, “Oral oestrogen replacement therapy versus placebo for hot flushes,” Cochrane Database of Systematic Reviews, no. 1, Article ID CD002978, 2001.
- A. H. Maclennan, J. L. Broadbent, S. Lester, and V. Moore, “Oral oestrogen and combined oestrogen/progestogen therapy versus placebo for hot flushes,” The Cochrane Database of Systematic Reviews, no. 4, Article ID CD002978, 2004.
- D. W. Sturdee, “The menopausal hot flush—anything new?” Maturitas, vol. 60, no. 1, pp. 42–49, 2008.
- Collaborative Group on Hormonal Factors in Breast Cancer, “Breast cancer and hormone replacement therapy: collaborative reanalysis of data from 51 epidemiological studies of 52,705 women with breast cancer and 108,411 women without breast cancer,” Lancet, vol. 350, no. 9084, pp. 1047–1059, 1997.
- V. Beral, “Breast cancer and hormone-replacement therapy in the Million Women Study,” Lancet, vol. 362, no. 9382, pp. 419–427, 2003.
- R. T. Chlebowski, S. L. Hendrix, R. D. Langer et al., “Influence of estrogen plus progestin on breast cancer and mammography in healthy postmenopausal women: the women's health initiative randomized trial,” Journal of the American Medical Association, vol. 289, no. 24, pp. 3243–3253, 2003.
- M. L. Stefanick, G. L. Anderson, K. L. Margolis et al., “Effects of conjugated equine estrogens on breast cancer and mammography screening in postmenopausal women with hysterectomy,” Journal of the American Medical Association, vol. 295, no. 14, pp. 1647–1657, 2006.
- ESCOP, Cimicifugae Rhizoma. Black Cohosh, ESCOP Monographs, Scientific Foundation for Herbal Medicinal Products, Georg Thieme-Verlag, Stuttgart, Germany, 2nd edition, 2003.
- Committee on Herbal Medicinal Products (HMPC), “Community herbal monograph on Cimicifuga racemosa (L.) Nutt., rhizoma., European Medicines Agency,” vol. EMA/HMPC/600717/2007, 2010.
- S. D. Reed, K. M. Newton, A. Z. LaCroix, L. C. Grothaus, V. S. Grieco, and K. Ehrlich, “Vaginal, endometrial, and reproductive hormone findings: Randomized, placebo-controlled trial of black cohosh, multibotanical herbs, and dietary soy for vasomotor symptoms: the Herbal Alternatives for Menopause (HALT) Study,” Menopause, vol. 15, no. 1, pp. 51–58, 2008.
- W. Wuttke, C. Gorkow, and D. Seidlová-Wuttke, “Effects of black cohosh (Cimicifuga racemosa) on bone turnover, vaginal mucosa, and various blood parameters in postmenopausal women: a double-blind, placebo-controlled, and conjugated estrogens-controlled study,” Menopause, vol. 13, no. 2, pp. 185–196, 2006.
- W. Wuttke, D. Seidlová-Wuttke, and C. Gorkow, “The Cimicifuga preparation BNO 1055 vs. conjugated estrogens in a double-blind placebo-controlled study: effects on menopause symptoms and bone markers,” Maturitas, vol. 44, pp. S67–S77, 2003.
- M. Oktem, D. Eroglu, H. B. Karahan, N. Taskintuna, E. Kuscu, and H. B. Zeyneloglu, “Black cohosh and fluoxetine in the treatment of postmenopausal symptoms: a prospective, randomized trial,” Advances in Therapy, vol. 24, no. 2, pp. 448–461, 2007.
- R. L. Ruhlen, G. Y. Sun, and E. R. Sauter, “Black cohosh: insights into its mechanism(s) of action,” Integrative Medicine Insights, vol. 2008, no. 3, pp. 21–32, 2008.
- R. Osmers, M. Friede, E. Liske, J. Schnitker, J. Freudenstein, and H. H. Henneicke-Von Zepelin, “Efficacy and safety of isopropanolic black cohosh extract for climacteric symptoms,” Obstetrics and Gynecology, vol. 105, no. 5, part 1, pp. 1074–1083, 2005.
- W. Stoll, “Phytotherapeuticon influences atrophic vaginal epithelium,” Therapeutikon, vol. 1, no. 23, pp. 23–31, 1987.
- E. Liske, W. Hänggi, H. H. Henneicke-von Zepelin et al., “Physiological investigation of a unique extract of black cohosh (Cimicifugae racemosae rhizoma): A 6-month clinical study demonstrates no systemic estrogenic effect,” Journal of Women's Health and Gender-Based Medicine, vol. 11, no. 2, pp. 163–174, 2002.
- W. Bai, H.-H. Henneicke-von Zepelin, S. Wang et al., “Efficacy and tolerability of a medicinal product containing an isopropanolic black cohosh extract in Chinese women with menopausal symptoms: a randomized, double blind, parallel-controlled study versus tibolone,” Maturitas, vol. 58, no. 1, pp. 31–41, 2007.
- P. Aidelsburger, S. Schauer, K. Grabein, et al., “Alternative methods for the treatment of post-menopausal troubles,” GMS Health Technology Assessment, vol. 8, Doc03, 2012.
- F. Borrelli and E. Ernst, “Alternative and complementary therapies for the menopause,” Maturitas, vol. 66, no. 4, pp. 333–343, 2010.
- V. C. K. Wong, C. E. D. Lim, X. Luo, and W. S. F. Wong, “Current alternative and complementary therapies used in menopause,” Gynecological Endocrinology, vol. 25, no. 3, pp. 166–174, 2009.
- C. Palacio, G. Masri, and A. D. Mooradian, “Black cohosh for the management of menopausal symptoms: a systematic review of clinical trials,” Drugs and Aging, vol. 26, no. 1, pp. 23–36, 2009.
- T. Shams, M. S. Setia, R. Hemmings, J. McCusker, M. Sewitch, and A. Ciampi, “Efficacy of black cohosh-containing preparations on menopausal symptoms: a meta-analysis,” Alternative Therapies in Health and Medicine, vol. 16, no. 1, pp. 36–44, 2010.
- S. Kupperman, B. B. Wetchler, and M. H. Blatt, “Contemporary therapy of the menopausal syndrome,” Journal of the American Medical Association, vol. 171, no. 12, pp. 1627–1637, 1959.
- K. Halmesmäki, R. Hurskainen, A. Tiitinen et al., “A randomized controlled trial hysterectomy of levenorgestrel-releasing intrauterine system in the treatment of menorrhagia—effect of FSH levels and menopausal symptoms,” Human Reproduction, vol. 19, no. 2, pp. 378–382, 2004.
- S. E. Geller, L. P. Shulman, R. B. Van Breemen et al., “Safety and efficacy of black cohosh and red clover for the management of vasomotor symptoms: a randomized controlled trial,” Menopause, vol. 16, no. 6, pp. 1156–1166, 2009.
- H. P. G. Schneider, L. A. J. Heinemann, H. P. Rosemeier, P. Potthoff, and H. M. Behre, “The menopause rating scale (MRS): comparison with Kupperman index and quality-of-life scale SF-36,” Climacteric, vol. 3, no. 1, pp. 50–58, 2000.
- M. Todorova, Z. Kamenov, M. Baleva, V. Christov, and K. Nicolov, “Anticardiolipin antibodies during hormone replacement therapy in healthy postmenopausal women,” Maturitas, vol. 48, no. 4, pp. 393–397, 2004.
- E. Zaborowska, J. Brynhildsen, S. Damberg et al., “Effects of acupuncture, applied relaxation, estrogens and placebo on hot flushes in postmenopausal women: an analysis of two prospective, parallel, randomized studies,” Climacteric, vol. 10, no. 1, pp. 38–45, 2007.
- K. Rauš, C. Brucker, C. Gorkow, and W. Wuttke, “First-time proof of endometrial safety of the special black cohosh extract (Actaea or Cimicifuga racemosa extract) CR BNO 1055,” Menopause, vol. 13, no. 4, pp. 678–691, 2006.
- B. A. Pockaj, J. G. Gallagher, C. L. Loprinzi et al., “Phase III double-blind, randomized, placebo-controlled crossover trial of black cohosh in the management of hot flashes: NCCTG trial N01CC,” Journal of Clinical Oncology, vol. 24, no. 18, pp. 2836–2841, 2006.