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Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 265023, 14 pages
Ginseng and Its Active Components Ginsenosides Inhibit Adipogenesis in 3T3-L1 Cells by Regulating MMP-2 and MMP-9
1Department of Life Sciences, Mokwon University, Daejeon 302-729, Republic of Korea
2Genome Research Center, KRIBB, Daejeon 305-806, Republic of Korea
3Department of Formula Sciences, College of Oriental Medicine, Dong-Eui University, Busan 614-052, Republic of Korea
Received 29 July 2012; Revised 27 September 2012; Accepted 4 October 2012
Academic Editor: Chong-Zhi Wang
Copyright © 2012 Jaeho Oh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- C. Couillard, P. Mauriège, P. Imbeault et al., “Hyperleptinemia is more closely associated with adipose cell hypertrophy than with adipose tissue hyperplasia,” International Journal of Obesity and Related Metabolic Disorders, vol. 24, no. 6, pp. 782–788, 2000.
- D. L. Crandall, G. J. Hausman, and J. G. Kral, “A review of the microcirculation of adipose tissue: anatomic, metabolic, and angiogenic perspectives,” Microcirculation, vol. 4, no. 2, pp. 211–232, 1997.
- R. Visse and H. Nagase, “Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry,” Circulation Research, vol. 92, no. 8, pp. 827–839, 2003.
- H. R. Lijnen, E. Maquoi, L. B. Hansen, B. Van Hoef, L. Frederix, and D. Collen, “Matrix metalloproteinase inhibition impairs adipose tissue development in mice,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 22, no. 3, pp. 374–379, 2002.
- R. E. Galardy, D. Grobelny, H. G. Foellmer, and L. A. Fernandez, “Inhibition of angiogenesis by the matrix metalloprotease inhibitor N-[2R- 2-(hydroxamidocarbonymethyl)-4-methylpentanoyl)]-L-tryptophan methylamide,” Cancer Research, vol. 54, no. 17, pp. 4715–4718, 1994.
- A. Bouloumié, C. Sengenès, G. Portolan, J. Galitzky, and M. Lafontan, “Adipocyte produces matrix metalloproteinases 2 and 9: involvement in adipose differentiation,” Diabetes, vol. 50, no. 9, pp. 2080–2086, 2001.
- N. Kawaguchi, K. Toriyama, E. Nicodemou-Lena, K. Inou, S. Torii, and Y. Kitagawa, “De novo adipogenesis in mice at the site of injection of basement membrane and basic fibroblast growth factor,” Proceedings of the National Academy of Sciences of the United States of America, vol. 95, no. 3, pp. 1062–1066, 1998.
- V. Christiaens and H. R. Lijnen, “Role of the fibrinolytic and matrix metalloproteinase systems in development of adipose tissue,” Archives of Physiology and Biochemistry, vol. 112, no. 4-5, pp. 254–259, 2006.
- C. Chavey, B. Mari, M. N. Monthouel et al., “Matrix metalloproteinases are differentially expressed in adipose tissue during obesity and modulate adipocyte differentiation,” The Journal of Biological Chemistry, vol. 278, no. 14, pp. 11888–11896, 2003.
- E. Maquoi, C. Munaut, A. Colige, D. Collen, and H. R. Lijnen, “Modulation of adipose tissue expression of murine matrix metalloproteinases and their tissue inhibitors with obesity,” Diabetes, vol. 51, no. 4, pp. 1093–1101, 2002.
- G. Croissandeau, M. Chrétien, and M. Mbikay, “Involvement of matrix metalloproteinases in the adipose conversion of 3T3-L1 preadipocytes,” The Biochemical Journal, vol. 364, no. 4, pp. 739–746, 2002.
- C. N. Gillis, “Panax ginseng pharmacology: a nitric oxide link?” Biochemical Pharmacology, vol. 54, no. 1, pp. 1–8, 1997.
- A. S. Attele, J. A. Wu, and C. S. Yuan, “Ginseng pharmacology: multiple constituents and multiple actions,” Biochemical Pharmacology, vol. 58, no. 11, pp. 1685–1693, 1999.
- J. M. Lü, Q. Yao, and C. Chen, “Ginseng compounds: an update on their molecular mechanisms and medical applications,” Current Vascular Pharmacology, vol. 7, no. 3, pp. 293–302, 2009.
- P. Y. K. Yue, D. Y. L. Wong, P. K. Wu et al., “The angiosuppressive effects of 20(R)- ginsenoside Rg3,” Biochemical Pharmacology, vol. 72, no. 4, pp. 437–445, 2006.
- T. M. Xu, M. H. Cui, Y. Xin et al., “Inhibitory effect of ginsenoside Rg3 on ovarian cancer metastasis,” Chinese Medical Journal, vol. 121, no. 15, pp. 1394–1397, 2008.
- J. Fujimoto, H. Sakaguchi, I. Aoki, H. Toyoki, S. Khatun, and T. Tamaya, “Inhibitory effect of ginsenoside-Rb2 on invasiveness of uterine endometrial cancer cells to the basement membrane,” European Journal of Gynaecological Oncology, vol. 22, no. 5, pp. 339–341, 2001.
- J. H. Yoon, Y. J. Choi, S. W. Cha, and S. G. Lee, “Anti-metastatic effects of ginsenoside Rd via inactivation of MAPK signaling and induction of focal adhesion formation,” Phytomedicine, vol. 19, no. 3-4, pp. 284–292, 2012.
- Y. L. Ho, K. C. Li, W. Chao, Y. S. Chang, and G. J. Huang, “Korean red ginseng suppresses metastasis of human hepatoma SK-Hep1 cells by inhibiting matrix metalloproteinase-2/-9 and urokinase plasminogen activator,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 965846, 8 pages, 2012.
- M. Yoon, H. Lee, S. Jeong et al., “Peroxisome proliferator-activated receptor is involved in the regulation of lipid metabolism by ginseng,” British Journal of Pharmacology, vol. 138, no. 7, pp. 1295–1302, 2003.
- E. D. Rosen and B. M. Spiegelman, “Molecular regulation of adipogenesis,” Annual Review of Cell and Developmental Biology, vol. 16, pp. 145–171, 2000.
- K. C. Huang, The Pharmacology of Chinese Herbs, CRC Press, Boca Raton, Fla, USA, 1999.
- S. Odashima, T. Ohta, H. Kohno, et al., “Control of phenotypic expression of cultured B16 melanoma cells by plant glycosides,” Cancer Research, vol. 45, no. 6, pp. 2781–2784, 1985.
- D. Tsang, H. W. Yeung, W. W. Tso, and H. Peck, “Ginseng saponins: influence on neurotransmitter uptake in rat brain synaptosomes,” Planta Medica, vol. 3, pp. 221–224, 1985.
- L. P. Christensen, “Ginsenosides chemistry, biosynthesis, analysis, and potential health effects,” Advances in Food and Nutrition Research, vol. 55, pp. 1–99, 2008.
- F. M. Gregoire, C. M. Smas, and H. S. Sul, “Understanding adipocyte differentiation,” Physiological Reviews, vol. 78, no. 3, pp. 783–809, 1998.
- E. D. Rosen, “The transcriptional basis of adipocyte development,” Prostaglandins Leukotrienes and Essential Fatty Acids, vol. 73, no. 1, pp. 31–34, 2005.
- T. Sadowski, S. Dietrich, F. Koschinsky, and R. Sedlacek, “Matrix metalloproteinase 19 regulates insulin-like growth factor-mediated proliferation, migration, and adhesion in human keratinocytes through proteolysis of insulin-like growth factor binding protein-3,” Molecular Biology of the Cell, vol. 14, no. 11, pp. 4569–4580, 2003.
- D. E. Gomez, D. F. Alonso, H. Yoshiji, and U. P. Thorgeirsson, “Tissue inhibitors of metalloproteinases: structure, regulation and biological functions,” European Journal of Cell Biology, vol. 74, no. 2, pp. 111–122, 1997.
- Y. T. Lo, Y. H. Tsai, S. J. Wu, J. R. Chen, and J. C. Chao, “Ginsenoside Rb1 inhibits cell activation and liver fibrosis in rat hepatic stellate cells,” Journal of Medicinal Food, vol. 14, no. 10, pp. 1135–1143, 2011.
- S. Y. Kim, D. H. Kim, S. J. Han, J. W. Hyun, and H. S. Kim, “Repression of matrix metalloproteinase gene expression by ginsenoside Rh2 in human astroglioma cells,” Biochemical Pharmacology, vol. 74, no. 11, pp. 1642–1651, 2007.
- C. M. Alexander, S. Selvarajan, J. Mudgett, and Z. Werbc, “Stromelysin-1 regulates adipogenesis during mammary gland involution,” The Journal of Cell Biology, vol. 152, no. 4, pp. 693–703, 2001.
- M. Van Hul, D. Bauters, U. Himmelreich, et al., “Effect of gelatinase inhibition on adipogenesis and adipose tissue development,” Clinical and Experimental Pharmacology & Physiology, vol. 39, no. 1, pp. 49–56, 2012.
- H. Qin, Y. Sun, and E. N. Benveniste, “The transcription factors Sp1, Sp3, and AP-2 are required for constitutive matrix metalloproteinase-2 gene expression in astroglioma cells,” The Journal of Biological Chemistry, vol. 274, no. 41, pp. 29130–29137, 1999.
- J. Yao, S. Xiong, K. Klos et al., “Multiple signaling pathways involved in activation of matrix metalloproteinase-9 (MMP-9) by heregulin-β1 in human breast cancer cells,” Oncogene, vol. 20, no. 56, pp. 8066–8074, 2001.
- A. S. Attele, Y. P. Zhou, J. T. Xie et al., “Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component,” Diabetes, vol. 51, no. 6, pp. 1851–1858, 2002.
- D. Washida and S. Kitanaka, “Determination of polyacetylenes and ginsenosides in Panax species using high performance liquid chromatography,” Chemical & Pharmaceutical Bulletin, vol. 51, no. 11, pp. 1314–1317, 2003.
- W. Lim, K. W. Mudge, and F. Vermeylen, “Effects of population, age, and cultivation methods on ginsenoside content of wild American ginseng (Panax quinquefolium),” Journal of Agricultural and Food Chemistry, vol. 53, no. 22, pp. 8498–8505, 2005.
- W. Shang, Y. Yang, B. Jiang et al., “Ginsenoside Rb1 promotes adipogenesis in 3T3-L1 cells by enhancing PPARγ2 and C/EBPα gene expression,” Life Sciences, vol. 80, no. 7, pp. 618–625, 2007.