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Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 271462, 10 pages
http://dx.doi.org/10.1155/2012/271462
Research Article

Banxia Baizhu Tianma Decoction for Essential Hypertension: A Systematic Review of Randomized Controlled Trials

1Department of Cardiology, Guang′anmen Hospital, China Academy of Chinese Medical Sciences, Beixiange 5, Xicheng District, Beijing 100053, China
2Department of Gastroenterology, Guang′anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China
3Graduate School, China Academy of Chinese Medical Sciences, Beijing 100700, China
4Department of Endocrinology, Traditional Chinese Medicine Hospital of Mentougou District, Beijing 102300, China
5Department of Cardiology, Traditional Chinese Medicine Hospital of Beijing, Beijing 100010, China

Received 23 August 2012; Revised 16 November 2012; Accepted 22 November 2012

Academic Editor: MyeongSoo Lee

Copyright © 2012 Xingjiang Xiong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objectives. To assess the current clinical evidence of Banxia Baizhu Tianma Decoction (BBTD) for essential hypertension (EH). Search Strategy. Electronic databases were searched until July 2012. Inclusion Criteria. We included randomized clinical trials testing BBTD against placebo, antihypertensive drugs, or combined with antihypertensive drugs against antihypertensive drugs. Data Extraction and Analyses. Study selection, data extraction, quality assessment, and data analyses were conducted according to Cochrane standards. Results. 16 randomized trials were included. Methodological quality of the included trials was evaluated as generally low. 2 trials compared prescriptions based on BBTD using alone with antihypertensive drugs. Meta-analysis showed no significant effect of modified BBTD compared with captopril in systolic blood pressure (MD: −0.75 (−5.77, 4.27); ) and diastolic blood pressure (MD: −0.75 (−2.89, 1.39); ). 14 trials compared the combination of BBTD or modified BBTD plus antihypertensive drugs with antihypertensive drugs. Meta-analysis showed there are significant beneficial effect on systolic blood pressure in the combination group compare to the antihypertensive drugs (MD: −4.33 (−8.44, −0.22); ). The safety of BBTD is uncertain. Conclusions. There is encouraging evidence of BBTD for lowering SBP, but evidence remains weak. Rigorously designed trials are warranted to confirm these results.