Comprehensive Evaluation of Anti-hyperglycemic Activity of Fractionated Momordica charantia Seed Extract in Alloxan-Induced Diabetic Rats

Table 1

Effect of different fractions of M. charantia seed extract on serum glucose levels (mg/dL) in diabetic rats.

Period (days) of treatment	0	1	3
Treatment
Normal	83±3.6	84.4±4.03	83.4±5.3
PBS	457±72.9	581±69.2	615±98.5
Mc-1	453±80.5	347±86.2^∗	318±82^∗∗
Mc-2	463±41	432±54.5	ND
Mc-3	445±75.1	317±65.0^∗	246±22.5^∗∗∗
Insulin	394.8±40.1	329.4±23.8^∗	336.5±29.9

The diabetic animals were treated with different fractions (Mc-1, Mc-2, and Mc-3) at a dose of 15 mg/kg b.wt. and protamine zinc insulin (10 IU/kg b.wt), once daily for 3 days. Control normal and control diabetic animals were treated with corresponding volume of PBS. The data represent mean ± S.D. Each group consisted of at least 5-6 animals. ^∗𝑃<0.05; ^∗∗𝑃<0.01; ^∗∗∗𝑃<0.001 compared with the respective group on day 0. ND indicates “not determined.”