Review Article
Applications of New Technologies and New Methods in ZHENG Differentiation
Table 1
Brief introduction of “Omics” and bioinformatics.
| Omics | Objects | Technologies and methods | Advantages | Disadvantages | Literatures |
| Genomics (transcriptomics) | DNA, mRNA | Gene sequence, differential display, subtractive hybridization, EST, SAGE, chip technology | Gene polymorphism Susceptibility for prognosis and treatment Completed database High throughput | Nonassociation to regulation of life activities Nonconsistent strictly with mRNA expression | Wu et al. [11] Lu et al. [12] |
| Proteomics | Amino acids, protein | Cleaving isotope-coded affinity tag, 2D-MS, 2D-HCLP | Performer of life function | Instability Variability | Liu et al. [14] Wu et al. [15] |
| Metabonomics | Metabolites | NMR, GC-MS, LC-MS | Amplified action Simplicity to detect Less numbers Similarities in different species | Lack of beneficial supports Interferences by physiological factors | Van Wietmarschen et al. [17] Sun et al. [18] Liu et al. [19] |
| Bioinformatics | Data, bioinformation | Data mining, network analysis, topological comparison, and so on | Totally holism Exploration of the potential of information Focusing on function relation | Needing of self-development | Li [49] |
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