Review Article
Applications of New Technologies and New Methods in ZHENG Differentiation
Table 1
Brief introduction of “Omics” and bioinformatics.
| | Omics | Objects | Technologies and methods | Advantages | Disadvantages | Literatures |
| Genomics
(transcriptomics) | DNA,
mRNA | Gene sequence,
differential display,
subtractive hybridization,
EST, SAGE, chip technology | Gene polymorphism
Susceptibility for prognosis
and treatment
Completed database
High throughput | Nonassociation to
regulation of life
activities
Nonconsistent strictly
with mRNA expression | Wu et al. [11]
Lu et al. [12] |
| | Proteomics | Amino acids,
protein | Cleaving isotope-coded affinity tag,
2D-MS, 2D-HCLP | Performer of life function | Instability
Variability | Liu et al. [14]
Wu et al. [15] |
| | Metabonomics | Metabolites | NMR, GC-MS, LC-MS | Amplified action
Simplicity to detect
Less numbers
Similarities in
different species | Lack of beneficial
supports
Interferences by
physiological factors | Van Wietmarschen et al. [17]
Sun et al. [18]
Liu et al. [19] |
| | Bioinformatics | Data,
bioinformation | Data mining, network analysis, topological
comparison, and so on | Totally holism Exploration of
the potential of information
Focusing on function relation | Needing
of self-development | Li [49] |
|
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