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Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 305319, 13 pages
Intestinal, Airway, and Cardiovascular Relaxant Activities of Thymoquinone
1Department of Biological and Biomedical Sciences, Aga Khan University, Sind, Karachi 74800, Pakistan
2Department of Medicine, St. Joseph's Hospital, McMaster University, Room T3338, 50 Charlton Avenue East, Hamilton, ON, Canada L8N 4A6
Received 6 September 2012; Accepted 28 November 2012
Academic Editor: Vincenzo De Feo
Copyright © 2012 Muhammad Nabeel Ghayur et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- M. S. Butt and M. T. Sultan, “Nigella sativa: reduces the risk of various maladies,” Critical Reviews in Food Science and Nutrition, vol. 50, no. 7, pp. 654–665, 2010.
- C. Grosso, A. C. Figueiredo, J. Burillo et al., “Enrichment of the thymoquinone content in volatile oil from Satureja montana using supercritical fluid extraction,” Journal of Separation Science, vol. 32, no. 2, pp. 328–334, 2009.
- H. A. Johnson, L. L. Rogers, M. L. Alkire, T. G. McCloud, and J. L. McLaughlin, “Bioactive monoterpenes from Monarda fistulosa (Lamiaceae),” Natural Product Letters, vol. 11, no. 4, pp. 241–250, 1998.
- J. A. Duke, “Dr. Duke's Phytochemical and Ethnobotanical Databases,” http://www.ars-grin.gov/duke/.
- M. N. Nagi, K. Alam, O. A. Badary, O. A. Al-Shabanah, H. A. Al-Sawaf, and A. M. Al-Bekairi, “Thymoquinone protects against carbon tetrachloride hepatotoxicity in mice via an antioxidant mechanism,” Biochemistry and Molecular Biology International, vol. 47, no. 1, pp. 153–159, 1999.
- M. M. Sayed-Ahmed, A. M. Aleisa, S. S. Al-Rejaie et al., “Thymoquinone attenuates diethylnitrosamine induction of hepatic carcinogenesis through antioxidant signaling,” Oxidative Medicine and Cellular Longevity, vol. 3, no. 4, pp. 254–261, 2010.
- V. Hajhashemi, A. Ghannadi, and H. Jafarabadi, “Black cumin seed essential oil, as a potent analgesic and antiinflammatory drug,” Phytotherapy Research, vol. 18, no. 3, pp. 195–199, 2004.
- M. Kanter, “Protective effects of thymoquinone on streptozotocin-induced diabetic nephropathy,” Journal of Molecular Histology, vol. 40, no. 2, pp. 107–115, 2009.
- M. Kanter, “Nigella sativa and derived thymoquinone prevents hippocampal neurodegeneration after chronic toluene exposure in rats,” Neurochemical Research, vol. 33, no. 3, pp. 579–588, 2008.
- P. S. Koka, D. Mondal, M. Schultz, A. B. Abdel-Mageed, and K. C. Agrawal, “Studies on molecular mechanisms of growth inhibitory effects of thymoquinone against prostate cancer cells: role of reactive oxygen species,” Experimental Biology and Medicine, vol. 235, no. 6, pp. 751–760, 2010.
- A. U. H. Gilani, M. N. Ghayur, A. Khalid, et al., “Presence of antispasmodic, antidiarrheal, antisecretory, calcium antagonist and acetylcholinesterase inhibitory steroidal alkaloids in Sarcococca saligna,” Planta Medica, vol. 71, no. 2, pp. 120–125, 2005.
- A. J. Farre, M. Colombo, M. Fort, and B. Gutierrez, “Differential effects of various Ca2+ antagonists,” General Pharmacology, vol. 22, no. 1, pp. 177–181, 1991.
- J. M. Van Rossum, “Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters,” Archives Internationales de Pharmacodynamie et de Therapie, vol. 143, pp. 299–330, 1963.
- M. N. Ghayur and A. H. Gilani, “Studies on cardio-suppressant, vasodilator and tracheal relaxant effects of Sarcococca saligna,” Archives of Pharmacal Research, vol. 29, no. 11, pp. 990–997, 2006.
- A. Bergner and M. J. Sanderson, “Acetylcholine-induced calcium signaling and contraction of airway smooth muscle cells in lung slices,” Journal of General Physiology, vol. 119, no. 2, pp. 187–198, 2002.
- M. N. Ghayur, A. H. Gilani, and L. J. Janssen, “Ginger attenuates acetylcholine-induced contraction and Ca2+ signalling in murine airway smooth muscle cells,” Canadian Journal of Physiology and Pharmacology, vol. 86, no. 5, pp. 264–271, 2008.
- L. J. Janssen, T. Tazzeo, J. Zuo, E. Pertens, and S. Keshavjee, “KC1 evokes contraction of airway smooth muscle via activation of RhoA and Rho-kinase,” American Journal of Physiology, vol. 287, no. 4, pp. L852–L858, 2004.
- R. F. Furchgott and J. V. Zawadzki, “The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine,” Nature, vol. 288, no. 5789, pp. 373–376, 1980.
- M. N. Ghayur and A. H. Gilani, “Ginger lowers blood pressure through blockade of voltage-dependent calcium channels,” Journal of Cardiovascular Pharmacology, vol. 45, no. 1, pp. 74–80, 2005.
- H. Karaki, H. Ozaki, M. Hori et al., “Calcium movements, distribution, and functions in smooth muscle,” Pharmacological Reviews, vol. 49, no. 2, pp. 157–230, 1997.
- T. B. Bolton, “Mechanisms of action of transmitters and other substances on smooth muscle,” Physiological Reviews, vol. 59, no. 3, pp. 606–718, 1979.
- M. Blanuša, V. M. Varnai, M. Piasek, and K. Kostial, “Chelators as antidotes of metal toxicity: therapeutic and experimental aspects,” Current Medicinal Chemistry, vol. 12, no. 23, pp. 2771–2794, 2005.
- A. H. Gilani, N. Aziz, I. M. Khurram, K. S. Chaudhary, and A. Iqbal, “Bronchodilator, spasmolytic and calcium antagonist activities of Nigella sativa seeds (Kalonji): a traditional herbal product with multiple medicinal uses,” Journal of the Pakistan Medical Association, vol. 51, no. 3, pp. 115–120, 2001.
- T. Godfraind, “Classification of calcium antagonists,” American Journal of Cardiology, vol. 59, pp. 11B–23B, 1987.
- A. H. Gilani and K. Aftab, “Presence of acetylcholine-like substance(s) in Sesamum indicum,” Archives of Pharmacal Research, vol. 15, no. 1, pp. 95–98, 1992.
- A. A. Al-Majed, M. H. Daba, Y. A. Asiri, O. A. Al-Shabanah, A. A. Mostafa, and H. A. El-Kashef, “Thymoquinone-induced relaxation of guinea-pig isolated trachea,” Research Communications in Molecular Pathology and Pharmacology, vol. 110, no. 5-6, pp. 333–345, 2001.
- A. A. Mahgoub, “Thymoquinone protects against experimental colitis in rats,” Toxicology Letters, vol. 143, no. 2, pp. 133–143, 2003.
- H. S. El-Abhar, D. M. Abdallah, and S. Saleh, “Gastroprotective activity of Nigella sativa oil and its constituent, thymoquinone, against gastric mucosal injury induced by ischaemia/reperfusion in rats,” Journal of Ethnopharmacology, vol. 84, no. 2-3, pp. 251–258, 2003.
- M. N. Ghayura and A. H. Gilani, “α-adrenergic receptor mediated hypertensive and vasoconstrictor effects of dietary radish leaves extract,” Journal of Health Science, vol. 53, no. 2, pp. 151–155, 2007.
- J. F. Perez and M. J. Sanderson, “The frequency of calcium oscillations induced by 5-HT, ACH, and KCl determine the contraction of smooth muscle cells of intrapulmonary bronchioles,” Journal of General Physiology, vol. 125, no. 6, pp. 535–553, 2005.
- N. Wienkötter, D. Höpner, U. Schütte et al., “The effect of nigellone and thymoquinone on inhibiting trachea contraction and mucociliary clearance,” Planta Medica, vol. 74, no. 2, pp. 105–108, 2008.
- M. Mansour and S. Tornhamre, “Inhibition of 5-lipoxygenase and leukotriene C4 synthase in human blood cells by thymoquinone,” Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 19, no. 5, pp. 431–436, 2004.
- R. Keyhanmanesh, M. H. Boskabady, M. J. Eslamizadeh, S. Khamneh, and M. A. Ebrahimi, “The Effect of thymoquinone, the main constituent of Nigella sativa on tracheal responsiveness and white blood cell count in lung lavage of sensitized guinea pigs,” Planta Medica, vol. 76, no. 3, pp. 218–222, 2010.
- M. El Gazzar, R. El Mezayen, M. R. Nicolls, J. C. Marecki, and S. C. Dreskin, “Downregulation of leukotriene biosynthesis by thymoquinone attenuates airway inflammation in a mouse model of allergic asthma,” Biochimica et Biophysica Acta, vol. 1760, no. 7, pp. 1088–1095, 2006.
- M. El Gazzar, R. El Mezayen, J. C. Marecki, M. R. Nicolls, A. Canastar, and S. C. Dreskin, “Anti-inflammatory effect of thymoquinone in a mouse model of allergic lung inflammation,” International Immunopharmacology, vol. 6, no. 7, pp. 1135–1142, 2006.
- L. J. Janssen and K. Killian, “Airway smooth muscle as a target of asthma therapy: history and new directions,” Respiratory Research, vol. 7, article 123, 2006.
- R. Othman, H. Ibrahim, M. A. Mohd, K. Awang, A. U. H. Gilani, and M. R. Mustafa, “Vasorelaxant effects of ethyl cinnamate isolated from Kaempferia galanga on smooth muscles of the rat aorta,” Planta Medica, vol. 68, no. 7, pp. 655–657, 2002.
- H. Karaki, “Inhibitory effects of calcium channel blockers in vascular smooth muscle,” in Proceedings of the Asia-Pacific Symposium on Ca2+-Antagonists, pp. 3–11, Churchill Livingstone, New York, NY, USA, 1993.
- A. Horowitz, C. B. Menice, R. Laporte, and K. G. Morgan, “Mechanisms of smooth muscle contraction,” Physiological Reviews, vol. 76, no. 4, pp. 967–1003, 1996.
- P. M. Vanhoutte, G. M. Rubanyi, V. M. Miller, and D. S. Houston, “Modulation of vascular smooth muscle contraction by the endothelium,” Annual Review of Physiology, vol. 48, pp. 307–320, 1986.
- E. Thorin, P. L. Huang, M. C. Fishman, and J. A. Bevan, “Nitric oxide inhibits α2-adrenoceptor-mediated endothelium-dependent vasodilation,” Circulation Research, vol. 82, no. 12, pp. 1323–1329, 1998.
- A. H. Gilani, M. N. Ghayur, Z. S. Saify, S. P. Ahmed, M. I. Choudhary, and A. Khalid, “Presence of cholinomimetic and acetylcholinesterase inhibitory constituents in betel nut,” Life Sciences, vol. 75, no. 20, pp. 2377–2389, 2004.
- G. M. Suddek, “Thymoquinone-induced relaxation of isolated rat pulmonary artery,” Journal of Ethnopharmacology, vol. 127, no. 2, pp. 210–214, 2010.
- M. M. Khattab and M. N. Nagi, “Thymoquinone supplementation attenuates hypertension and renal damage in nitric oxide deficient hypertensive rats,” Phytotherapy Research, vol. 21, no. 5, pp. 410–414, 2007.
- M. N. Nagi, O. A. Al-Shabanah, M. M. Hafez, and M. M. Sayed-Ahmed, “Thymoquinone supplementation attenuates cyclophosphamide-induced cardiotoxicity in rats,” Journal of Biochemical and Molecular Toxicology, vol. 25, no. 3, pp. 135–142, 2011.
- S. C. El, O. A. Al-Sagair, and M. I. Al-Khalaf, “Thymoquinone and Nigella sativa oil protection against methionine-induced hyperhomocysteinemia in rats,” International Journal of Cardiology, vol. 93, no. 1, pp. 19–23, 2004.
- M. A. Nader, D. S. El-Agamy, and G. M. Suddek, “Protective effects of propolis and thymoquinone on development of atherosclerosis in cholesterol-fed rabbits,” Archives of Pharmacal Research, vol. 33, no. 4, pp. 637–643, 2010.