- About this Journal ·
- Abstracting and Indexing ·
- Advance Access ·
- Aims and Scope ·
- Annual Issues ·
- Article Processing Charges ·
- Articles in Press ·
- Author Guidelines ·
- Bibliographic Information ·
- Citations to this Journal ·
- Contact Information ·
- Editorial Board ·
- Editorial Workflow ·
- Free eTOC Alerts ·
- Publication Ethics ·
- Reviewers Acknowledgment ·
- Submit a Manuscript ·
- Subscription Information ·
- Table of Contents
Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 308018, 8 pages
Pharmacokinetics and Relative Bioavailability of Flavonoids between Two Dosage Forms of Gegen-Qinlian-Tang in Rats
1School of Pharmacy, China Medical University, 91 Hsueh-Shih Road, Taichung 40402, Taiwan
2Department of Medical Research, China Medical University Hospital, Taichung 40402, Taiwan
Received 9 May 2012; Accepted 25 September 2012
Academic Editor: Chun Guang Li
Copyright © 2012 Chung-Ping Yu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Y. Wang, Y. Yao, R. An, L. You, and X. Wang, “Simultaneous determination of puerarin, daidzein, baicalin, wogonoside and liquiritin of GegenQinlian decoction in rat plasma by ultra-performance liquid chromatography-mass spectrometry,” Journal of Chromatography B, vol. 877, no. 20-21, pp. 1820–1826, 2009.
- W. H. Huang, A. R. Lee, and C. H. Yang, “Antioxidative and anti-inflammatory activities of polyhydroxyflavonoids of Scutellaria baicalensis GEORGI,” Bioscience, Biotechnology and Biochemistry, vol. 70, no. 10, pp. 2371–2380, 2006.
- X. Xu, S. Zhang, L. Zhang, W. Yan, and X. Zheng, “The neuroprotection of puerarin against cerebral ischemia is associated with the prevention of apoptosis in rats,” Planta Medica, vol. 71, no. 7, pp. 585–591, 2005.
- M. Ye, S. Fu, R. Pi, and F. He, “Neuropharmacological and pharmacokinetic properties of berberine: a review of recent research,” Journal of Pharmacy and Pharmacology, vol. 61, no. 7, pp. 831–837, 2009.
- M. Li-Weber, “New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin,” Cancer Treatment Reviews, vol. 35, no. 1, pp. 57–68, 2009.
- J. Tang, Y. Feng, S. Tsao, N. Wang, R. Curtain, and Y. Wang, “Berberine and Coptidis Rhizoma as novel antineoplastic agents: a review of traditional use and biomedical investigations,” Journal of Ethnopharmacology, vol. 126, no. 1, pp. 5–17, 2009.
- S. Hawthorne and S. Gallagher, “Effects of glycyrrhetinic acid and liquorice extract on cell proliferation and prostate-specific antigen secretion in LNCaP prostate cancer cells,” Journal of Pharmacy and Pharmacology, vol. 60, no. 5, pp. 661–666, 2008.
- H. M. Chiang, Y. R. Yeh, P. D. L. Chao et al., “Metabolic pharmacokinetics of isoflavones in the roots of Pueraria lobata in rats,” Mid-Taiwan Journal of Medicine, vol. 10, no. 2, pp. 57–64, 2005.
- M. Y. Lai, S. L. Hsiu, C. C. Chen, Y. C. Hou, and P. D. L. Chao, “Urinary pharmacokinetics of baicalein, wogonin and their glycosides after oral administration of Scutellariae Radix in humans,” Biological and Pharmaceutical Bulletin, vol. 26, no. 1, pp. 79–83, 2003.
- Y. T. Liu, H. P. Hao, H. G. Xie et al., “Extensive intestinal first-pass elimination and predominant hepatic distribution of berberine explain its low plasma levels in rats,” Drug Metabolism and Disposition, vol. 38, no. 10, pp. 1779–1784, 2010.
- X. Y. Chu, S. E. W. Huskey, M. P. Braun, B. Sarkadi, D. C. Evans, and R. Evers, “Transport of ethinylestradiol glucuronide and ethinylestradiol sulfate by the multidrug resistance proteins MRP1, MRP2, and MRP3,” Journal of Pharmacology and Experimental Therapeutics, vol. 309, no. 1, pp. 156–164, 2004.
- C. D. Klaassen and L. M. Aleksunes, “Xenobiotic, bile acid, and cholesterol transporters: function and regulation,” Pharmacological Reviews, vol. 62, no. 1, pp. 1–96, 2010.
- G. You, “Structure, function, and regulation of renal organic anion transporters,” Medicinal Research Reviews, vol. 22, no. 6, pp. 602–616, 2002.
- S. P. Lin, S. Y. Tsai, Y. C. Hou, and P. D. L. Chao, “Glycyrrhizin and licorice significantly affect the pharmacokinetics of methotrexate in rats,” Journal of Agricultural and Food Chemistry, vol. 57, no. 5, pp. 1854–1859, 2009.
- Y. C. Hou, S. P. Lin, S. Y. Tsai, M. H. Ko, Y. C. Chang, and P. D. L. Chao, “Flavonoid pharmacokinetics and tissue distribution after repeated dosing of the roots of Scutellaria baicalensis in rats,” Planta Medica, vol. 77, no. 5, pp. 455–460, 2011.
- C. Manach and J. L. Donovan, “Pharmacokinetics and metabolism of dietary flavonoids in humans,” Free Radical Research, vol. 38, no. 8, pp. 771–785, 2004.
- T. Walle, “Absorption and metabolism of flavonoids,” Free Radical Biology and Medicine, vol. 36, no. 7, pp. 829–837, 2004.
- P. D. Lee Chao, S. L. Hsiu, and Y. C. Hou, “Flavonoids in herbs: biological fates and potential interactions with xenobiotics,” Journal of Food and Drug Analysis, vol. 10, no. 4, pp. 219–228, 2002.
- P. C. H. Hollman, “Absorption, bioavailability, and metabolism of flavonoids,” Pharmaceutical Biology, vol. 42, pp. 74–83, 2004.
- Y. T. Lin, S. L. Hsiu, Y. C. Hou, H. Y. Chen, and P. D. L. Chao, “Degradation of flavonoid aglycones by rabbit, rat and human fecal flora,” Biological and Pharmaceutical Bulletin, vol. 26, no. 5, pp. 747–751, 2003.
- A. P. Wilkinson, J. M. Gee, M. S. Dupont et al., “Hydrolysis by lactase phlorizin hydrolase is the first step in the uptake of daidzein glucosides by rat small intestine in vitro,” Xenobiotica, vol. 33, no. 3, pp. 255–264, 2003.
- A. L. Simons, M. Renouf, S. Hendrich, and P. A. Murphy, “Human gut microbial degradation of flavonoids: structure-function relationships,” Journal of Agricultural and Food Chemistry, vol. 53, no. 10, pp. 4258–4263, 2005.
- B. Ploeger, T. Mensinga, A. Sips, J. Meulenbelt, and J. DeJongh, “A human physiologically-based model for glycyrrhzic acid, a compound subject to presystemic metabolism and enterohepatic cycling,” Pharmaceutical Research, vol. 17, no. 12, pp. 1516–1525, 2000.
- D. R. Doerge, H. G. Chang, M. I. Churchwell, and C. L. Holder, “Analysis of soy isoflavone conjugation in vitro and in human blood using liquid chromatography-mass spectrometry,” Drug Metabolism and Disposition, vol. 28, no. 3, pp. 298–307, 2000.
- L. Gu, S. E. House, R. L. Prior et al., “Metabolic phenotype of isoflavones differ among female rats, pigs, monkeys, and women,” Journal of Nutrition, vol. 136, no. 5, pp. 1215–1221, 2006.
- Y. J. Lin, Y. C. Hou, C. H. Lin et al., “Puerariae radix isoflavones and their metabolites inhibit growth and induce apoptosis in breast cancer cells,” Biochemical and Biophysical Research Communications, vol. 378, no. 4, pp. 683–688, 2009.
- N. Wang, L. J. Tang, G. Q. Zhu et al., “Apoptosis induced by baicalin involving up-regulation of P53 and bax in MCF-7 cells,” Journal of Asian Natural Products Research, vol. 10, no. 11-12, pp. 1129–1135, 2008.
- S. Ikemoto, K. Sugimura, N. Yoshida et al., “Antitumor effects of Scutellariae radix and its components baicalein, baicalin, and wogonin on bladder cancer cell lines,” Urology, vol. 55, no. 6, pp. 951–955, 2000.
- T. Lu, J. Song, F. Huang et al., “Comparative pharmacokinetics of baicalin after oral administration of pure baicalin, Radix scutellariae extract and Huang-Lian-Jie-Du-Tang to rats,” Journal of Ethnopharmacology, vol. 110, no. 3, pp. 412–418, 2007.
- R. Shi, H. Zhou, Z. Liu et al., “Influence of Coptis chinensis on pharmacokinetics of flavonoids after oral administration of radix Scutellariae in rats,” Biopharmaceutics & Drug Disposition, vol. 30, no. 7, pp. 398–410, 2009.