Pharmacokinetics and Relative Bioavailability of Flavonoids between Two Dosage Forms of Gegen-Qinlian-Tang in Rats

Table 2

Comparison of pharmacokinetic parameters between traditional decoction (TD) and concentrated powder (CP) of GQT.

Metabolites	Dosage form	𝐶max; (nmol/mL)	AUC0–4320; (nmol·min/mL)	MRT0–4320; (min)
Daidzein S/G	TD	8.9±1.2	13669.7±1704.7^a	1647.4±103.3
	CP	7.0±0.9	9720.4±853.4^b; (−28.9%)	1842.7±100.8
Baicalein S/G	TD	4.7±1.3	5445.1±1212.9	1513.7±209.8
	CP	3.2±0.5	3949.7±666.2	1451.3±85.2
Wogonin S/G	TD	1.7±0.4	2314.3±495.4	1409.7±163.9
	CP	1.1±0.3	1816.2±319.7	1476.5±100.9

Data expressed as mean ± S.E.
Means in a column without a common superscript difference, 𝑃<0.05.
𝐶_max: peak serum level.
AUC_0–4320: area under the serum concentration-time curve to 4320 min.
MRT: mean residence time.