The Observation of Humoral Responses after Influenza Vaccination in Patients with Rheumatoid Arthritis Treated with Japanese Oriental (Kampo) Medicine: An Observational Study

Table 2

GMTs and fold increase in GMT for influenza A/H3N2, A/H1N1, and B strains in RA patients treated with Kampo formulae before and after administration of influenza vaccines.

	Total	Without MTX group*	With MTX group**
GMT, mean ± SD
A/H1N1 strain
Baseline	12.1±14.0	11.0±12.1	14.1±15.0
4 weeks later	78.8±119.7	39.6±39.3	115.9±148.8
A/H3N2 strain
Baseline	13.5±13.9	16.0±19.7	11.7±10.2
4 weeks later	35.7±33.6	33.1±21.8	39.1±40.2
B strain
Baseline	12.8±10.3	13.9±9.2	11.4±11.5
4 weeks later	27.3±27.8	22.8±19.2	31.4±34.0
Fold increase, mean (range)
A/H1N1 strain	6.5 (1 to 64)	3.6 (1 to 16)	8.2 (1 to 64)
A/H3N2 strain	2.6 (1 to 16)	2.1 (1 to 8)	3.3 (1 to 16)
B strain	2.1 (1 to 16)	1.6 (1 to 4)	2.7 (1 to 16)

*Without MTX group: patients treated with classical DMARDs alone. Patients treated with tacllolimus were excluded. **with MTX group: patients treated with MTX, but not biologics.