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| Drug group (ATC-Code) | No (%) ADRs | Drugs (number of ADRs for each causative drug) | Adverse drug reactions main symptoms | CTCAE severity upgrade () |
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| Opioids (N02A) | 35 | Morphine (23), fentanyl (4), tramadol (4), oxycodone/naloxone (1), hydromorphone (1), oxycodone (1), and piritramide (1) | Constipation (19), nausea (9), nightmares (3), itching (1), disorientation (1), seizure (1), vomiting (1), emesis (1), hyperacusis (1), sedation (1), and haemolytic anaemia (1) | Grade II (28) grade III (7) |
|
| Penicillin/beta-lactamase inhibitors (J01C) | 40 | Sultamicillin (17), piperacillin (14), combactam (8), and amoxicillin (1) | Diarrhoea (10), C. difficile-associated diarrhoea (6), nausea (3), dyspnoea (2), emesis (2) allergic reactions (2), drug eruption (1), renal failure (1), and vaginal mycosis (1) | Grade II (22) grade III (17), and grade IV (1) |
|
| Cephalosporin/ Carbapenem (J01D) | 36 | Cefuroxime (23), ceftriaxone (10), and imipenem/cilastatin (3) | C. difficile-associated diarrhoea (12), diarrhoea (6), drug eruption (6), anaphylactic reaction grade III (1), seizures (1), tongue swelling (1), angioedema (1), renal failure (1), and collapse (1) | Grade II (16), grade III (16), grade IV (3), grade V (1) |
|
| Corticosteroids for Systemic Use (H02AB) | 17 | Prednisolone (7), dexamethasone (4), prednisone (5), and methylprednisolone (1) | Hyperglycaemia (10), psychotic reaction (2), confusion (1), hypertension (1), cephalgia (1), secondary sepsis (1), gastric ulcer (1), and oesophagitis (1) | Grade II (2), grade III (11), grade IV (4), and grade V (1) |
|
| Platelet aggregation inhibitors excluding heparin (B01AC) | 24 | Clopidogrel (6) and ASA (18) | Bleeding (11), anaemia (2), abdominal pain (1), gastric ulcer (1), and gastritis (1) | Grade II (14), grade III (4), and grade IV (6) |
|
| Loop diuretics (C03CA) | 16 | Furosemide (10) and torasemide (6) | Renal failure acute or chronic (12), hypotension (2), exsiccosis (2), itching (1), uraemia (1), pemphigoid reaction (1), and electrolyte disorder (1) | Grade II (9), grade III (4) grade IV (1), and grade V (2) |
|
| Quinolones (J01M) | 15 | Levofloxacin (7), ciprofloxacin (7), and moxifloxacin (1) | C. difficile-associated diarrhoea (2), diarrhoea (2), and increase in GT (2), alkaline phosphatase (2), vertigo (1), seizure (1), and constipation (1) | Grade II (6) and
grade III (9) |
|
| Macrolides (J01F) | 13 | Clarithromycin (9) and clindamycin (4) | C. difficile-associated diarrhoea (5), diarrhoea (3), membranous colitis (1), drug fever, (1) allergic reaction (1), and drug eruption (1) | Grade II (7) and grade III (6) |
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| Heparin group (B01AB) | 10 | Enoxaparin (8) and heparin (2) | Bleeding (10) | Grade II (6), grade III (2), and grade IV (2) |
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| Oral Antidiabetics (A10B) | 11 | Metformin (8) and exenatide (3) | Diarrhoea (7), meteorism (4), abdominal pain (1), nausea (1), and acute renal failure (1) | Grade II (10) and grade III (1) |
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