Dry Needling at Myofascial Trigger Spots of Rabbit Skeletal Muscles Modulates the Biochemicals Associated with Pain, Inflammation, and Hypoxia

Figure 1

Flow chart for the animal study. Abbreviations: 1D, one-dosage dry needling; 5D, five-dosage dry needling; BF, biceps femoris; COX-2, cyclooxygenase-2; DRG, dorsal root ganglion; End, 𝛽-endorphin; HIF-1𝛼, hypoxia-inducible factor-1𝛼; iNOS, inducible isoform of nitric oxide synthases; MTrS, myofascial trigger spot; SP, substance P; TNF-𝛼, tumor necrosis factor-𝛼; VEGF, vascular endothelial growth factor; s1D, sham one-dosage dry needling; s5D, sham five-dosage dry needling.