Effect of Combining Therapy with Traditional Chinese Medicine-Based Psychotherapy and Herbal Medicines in Women with Menopausal Syndrome: A Randomized Controlled Clinical Trial
Table 2
Difference in adjusted mean change of KI score between interventions and placebo Group*.
Time/weeks
CHM + PSY versus placebo
PSY versus placebo
CHM versus placebo
CHM + PSY versus PSY
CHM versus CHM + PSY
CHM versus PSY
Difference in mean change (95% CI)
value
adjust
Difference in mean change (95% CI)
value
adjust
Difference in mean change (95% CI)
value
adjust
Difference in mean change (95% CI)
value
adjust
Difference in mean change (95% CI)
value
adjust
Difference in mean change (95% CI)
value
adjust
4
−2.38
0.0109*
1
−1.49
0.1136
1
−0.64
0.4857
1
−0.89
0.3369
1
1.74
0.0567
1
0.84
0.3572
1
(−5.88–1.12)
(−5–2.03)
(−4.09–2.81)
(−4.39–2.6)
(−1.68–5.16)
(−2.59–4.28)
8
−3.08
0.0022*
0.6026
−1.99
0.0483*
1
−1.91
0.0532
1
−1.09
0.2751
1
1.17
0.2337
1
0.08
0.9373
1
(−6.85–0.69)
(−5.76–1.78)
(−5.61–1.79)
(−4.85–2.66)
(−2.52–4.86)
(−3.62–3.77)
12
−3.12
0.0034*
0.9401
−2
0.0598
1
−0.89
0.3927
1
−1.12
0.2928
1
2.23
0.0333*
1
1.11
0.2886
1
(−7.11–0.87)
(−5.98–1.98)
(−4.8–3.02)
(−5.1–2.87)
(−1.69–6.14)
(−2.8–5.02)
16
−3.27
0.0051*
1
−2.79
0.017*
1
−1.18
0.3011
1
−0.48
0.6808
1
2.09
0.0678
1
1.61
0.1605
1
(−7.65–1.1)
(−7.18–1.59)
(−5.48–3.11)
(−4.86–3.9)
(−2.2–6.38)
(−2.69–5.91)
20
−3.29
0.0046*
1
−2.17
0.0621
1
−0.74
0.5155
1
−1.12
0.3338
1
2.55
0.0248*
1
1.43
0.2089
1
(−7.63–1.06)
(−6.52–2.19)
(−5–3.52)
(−5.47–3.23)
(−1.7–6.8)
(−2.83–5.68)
24
−2.11
0.0585
1
−0.69
0.535
1
0.18
0.8676
1
−1.42
0.2041
1
2.3
0.0354*
1
0.88
0.4227
1
(−6.3–2.07)
(−4.89–3.5)
(−3.92–4.28)
(−5.61–2.77)
(−1.79–6.39)
(−3.22–4.98)
Over all time points
−2.88
0.0021*
0.0126*
−1.85
0.0476*
0.2853
−0.86
0.3463
1
−1.02
0.2736
1
2.01
0.0279*
0.1672
0.99
0.2797
1
(−5.34–0.41)
(−4.32–0.62)
(−3.29–1.56)
(−3.48–1.44)
(−0.4–4.43)
(−1.43–3.41)
*. *All analyses were conducted on the data adjusted for age (continuous), body mass index (kg/m2, continuous), menopausal status (menopause transition versus postmenopausal). Estimates of difference in mean change from baseline versus placebo, along with values and 95% CIs, from mixed-model analysis that used data from baseline and all follow-up time points (total, for adjusted analyses). Bonferroni method was adopted for the value adjustment in the multiple comparisons.
