Anti-Hepatitis B Virus Effect and Possible Mechanism of Action of 3,4-O-Dicaffeoylquinic Acid In Vitro and In Vivo

Table 2

Effect of 3,4-dicaffeoylquinic acid on the survival of D-GalN injured HL-7702 hepatocytes.

Groups	Concentration (μg/mL)	Absorbency (570 nm)	Protection rate (%)
Vehicle	—	1.289±0.055 **	—
D-GalN-control	—	0.769±0.053	—
Silybin-D-GalN	100	0.868±0.036 *	18.90
	50	0.832±0.055	12.07
	10	0.810±0.031	7.79
3,4-Dicaffeoylquinic acid- D-GalN	100	0.846±0.044	14.77
	50	0.812±0.031	8.18
	10	0.801±0.019	6.16

Silybin was used as the positive control. 0.1% DMSO was used as the vehicle control. Values are expressed as the means ± SD of four replicates. Protection rate (%) = (the mean absorbency value in experimental group − the mean absorbency value in model control group)/(the mean absorbency value in negative control group − the mean absorbency value in model control group) × 100%. *𝑃<0.05 and **𝑃<0.01 represent the significance of the difference from the D-GalN control.