Anti-Hepatitis B Virus Effect and Possible Mechanism of Action of 3,4-O-Dicaffeoylquinic Acid In Vitro and In Vivo

Table 6

Effect of 3,4-dicaffeoylquinic acid on the HBV cccDNA content of HepG2.2.15 cells.

Groups	Concentration (μg/mL)	HBV cccDNA (Log) (copy/μL)
Normal	—	2.79±0.03
Vehicle	—	2.73±0.02
Oxymatrine	50	2.59±0.12^∗
3,4-Dicaffeoylquinic acid	50	2.54±0.05^∗∗
	25	2.71±0.08
	10	2.83±0.03

Oxymatrine was used as the positive control. 0.1% DMSO was used as the vehicle control. Data are expressed as the means ± SD of three independent experiments. *𝑃<0.05 and **𝑃<0.01 compared with the vehicle group.