Anti-Hepatitis B Virus Effect and Possible Mechanism of Action of 3,4-O-Dicaffeoylquinic Acid In Vitro and In Vivo

Table 7

Effect of 3,4-dicaffeoylquinic acid on HO-1 expression in HepG2.2.15 cells. (After the cells were treated with the test compound for 6 days.)

Groups	Concentration (μg/mL)	HO-1 content (ng/g protein)
Normal	—	36.00±0.45
Vehicle	—	33.61±1.51
Oxymatrine	50	57.70±3.21^∗∗
	25	51.09±4.80^∗∗
	10	49.49±1.99^∗∗
3,4-Dicaffeoylquinic acid	50	57.18±3.37^∗∗
	25	48.31±2.52^∗∗
	10	45.12±0.87^∗∗

Oxymatrine was used as the positive control. 0.1% DMSO was used as the vehicle control. Data are expressed as the means ± SD of three independent experiments. *𝑃<0.05 and **𝑃<0.01 compared with the vehicle group.