Anti-Hepatitis B Virus Effect and Possible Mechanism of Action of 3,4-O-Dicaffeoylquinic Acid In Vitro and In Vivo

Table 8

Anti-HBV activity of 3,4-O-dicaffeoylquinic acid in HBV transgenic mice.

Groups	Concentration (mg/kg)	HBsAg	HO-1 (ng/L)
		P/N
Vehicle	—	55.33±1.10	609.62±39.54
Lamivudine	100	56.82±1.67	646.53±29.19
3,4-Dicaffeoylquinic acid	100	53.16±1.15^∗∗	676.31±31.81^∗
	50	53.62±1.49^∗	630.51±56.48

Lamivudine was used as the positive control in the anti-HBV assay. Normal saline solution was used as the vehicle control. P/N (positive-to-negative) ratios were determined as the mean absorbency value of the test compounds divided by that of the negative control. Data are expressed as the means ± SD of four samples. *𝑃<0.05 and **𝑃<0.01 compared with the vehicle group.