Evidence-Based Complementary and Alternative Medicine

Research Article

Ganoderma tsugae Induces S Phase Arrest and Apoptosis in Doxorubicin-Resistant Lung Adenocarcinoma H23/0.3 Cells via Modulation of the PI3K/Akt Signaling Pathway

Table 1

A comparison of the organ toxicity of the control and GTE treatment.
HeartLungKidneyBrainLiverSpleenIntestines
HNIHNIHNIHNIHNIHNIHNI
A1−−−++−−+−−−−−+−−+−−−−−
A2−−−+−−+−−−−−+−−+−−−−−
A3+−−++−−+−−−−−+−−+−−−−+
A4+−−+++−−+−−−−−+−−+−−−−−
A5+−−++−−−−−−−−+−−+−−−−−
A6++−−++−−+−−−−−+−−+−−−−+
B1+−−++−−+−−−−−++−−+−−−−+
B2++−−+++−−+−−−−−+−−+−−−−−
B3−−−++−−−−−−−−+−−+−−−−+
B4+++−−++−−+−−−−−+−−+−−−−−
B5+−−+++−−−−−−−−+−−+−−−−−
B6++−−+−−+−−−−−+−−+−−−−−
B7+−−++−−+−−−−−+−−+−−−−−
C1+−−++−−+−−−−−+−−+−−−−+
C2+−−+++−−+−−−−−+−−+−−−−+
C3+−−++−−+−−−−−+−−+−−−−−
C4+−−++−−+−−−−−+−−+−−−−−
C5+++−−+++−−+−−−−−+−−+−−−−+
C6+−−+++−−−−−−−−+−−+−−−−−
C7−−−++−−+−−−−−+−−+−−−−−
A1–6: mice that received neither a tumor implant nor GTE treatment; B1–7: mice that received a tumor implant but did not receive GTE treatment; C1–7: mice that received both a tumor implant and GTE treatment; H: hemorrhage; N: necrosis; I: Inflammation. The severity of the visual scoring system represented by “−” and “+”; − stands for none, + stands for minimal, ++ stands for visible, and +++ stands for apparent pathological change.