381904.fig.003a
(a)
381904.fig.003b
(b)
381904.fig.003c
(c)
381904.fig.003d
(d)
Figure 3: Effects of SGD on the proliferation of TRAP positive polykaryocytes (×1000). (a) Sham-op. group: TRAP positive polykaryocytes were rarely seen. (b) Model group: a large amount of scattered, strongly TRAP positive cells resided in the cancerous bone. (c) Zoledronic acid group and (d) SGD group: bone after treatment with Zoledronic acid or SGD contained only few, faintly stained TRAP positive profiles close to the bone.