Luteolin Suppresses Inflammatory Mediator Expression by Blocking the Akt/NFκB Pathway in Acute Lung Injury Induced by Lipopolysaccharide in Mice
Figure 2
Effect of luteolin on LPS-induced PMNs and protein accumulation in BALF. (a) PBS or 18–70 μmol/kg of luteolin were intraperitoneally injected for 30 min prior to intratracheal instillation of LPS (100 μg/50 μL saline) or saline in mice. Six hours later, the mice were anesthetized and BALF was collected for PMNs count. (b) Pulmonary permeability was determined by quantitating the protein content in cell-free BALF. (c) Pulmonary edema was determined by quantitating the wet/dry weight ratio. Values are expressed as means ± S.D. ( in each group). * versus control; # versus LPS group.
