Demethoxycurcumin Retards Cell Growth and Induces Apoptosis in Human Brain Malignant Glioma GBM 8401 Cells
Figure 3
Effects of DMC on cell cycle progression/distribution and apoptosis in GBM 8401 cells. (a) cell cycle distribution and (b) cell cycle analysis of sub-G1 in GBM 8401 cells after culturing with DMC for 24 h. Treatment with DMSO (0.1%) was used as the control. All data were reported as the means (±SEM) of at least three separate experiments. Statistical analysis used the t-test, with the significant differences determined at the level of versus 0 μM control group. (c) DMC induced the increase of both early apoptosis (Annexin V positive, PI negative) and late apoptosis/necrosis (Annexin V/PI double positive) in GBM 8401 cells for 4 h of incubation.
