Oroxylin A, but Not Vasopressin, Ameliorates Cardiac Dysfunction of Endotoxemic Rats
Figure 2
Effects of Oro-A and AVP on the CPP, CF, and coronary arterial function of isolated hearts from endotoxemic rats. The representative tracings in (a) indicate that Oro-A (10 μM) or AVP (0.2 IU/L) perfusion does not affect the mean of CPP; however, Oro-A (10 μM) perfusion increases while AVP (0.2 IU/L) perfusion decreases the pulse of CPP in constant pressure heart preparation from 5 hr post-LPS rats. In constant flow heart preparation (b), Oro-A (10 μM) decreases while AVP (0.2 IU/L) increases the CPP in the constant flow (14 mL/min) heart preparation from 5 hr post-LPS rats. The bar chart in (a) summarize effects of Oro-A (10 and 20 μM, solid bar) and AVP (0.2 and 0.4 IU/L, open bar) on CF in constant pressure heart preparation from 5 hr or 16 hr post-LPS rats. The bar chart in (b) summarize effects of Oro-A (10 and 20 μM, solid bar) and AVP (0.2 and 0.4 IU/L, open bar) on CPP in constant flow heart preparation from 5 hr or 16 hr post-LPS rats. Values of normal control and 5 hr and 16 hr post-LPS rats are from Table 1. Values are mean ± SEM ( each group). * versus respective LPS groups; # versus normal control; † versus 5 hr post-LPS group. CF (coronary flow); CPP (coronary perfusion pressure).
