Oroxylin A, but Not Vasopressin, Ameliorates Cardiac Dysfunction of Endotoxemic Rats
Figure 3
Effects of Oro-A and AVP on the LVDP of isolated hearts from endotoxemic rats. The representative tracings in (a) indicate that Oro-A (10 μM) perfusion increases while AVP (0.2 IU/L) perfusion decreases the LVDP in constant pressure heart preparation from 5 hr post-LPS rats. In constant flow heart preparation (b), Oro-A (10 μM) slightly but significantly increases LVDP, while AVP (0.2 IU/L) is without effect. The bar chart in (a) summarizes effects of Oro-A (10 and 20 μM, solid bar) and AVP (0.2 and 0.4 IU/L, open bar) on LVDP in constant pressure heart preparation from 5 hr or 16 hr post-LPS rats. The bar chart in (b) summarize effects of Oro-A (10 and 20 μM, solid bar) and AVP (0.2 and 0.4 IU/L, open bar) on LVDP in constant flow heart preparation from 5 hr or 16 hr post-LPS rats. Values of normal control, and 5 hr and 16 hr post-LPS rats are from Table 1. Values are mean ± SEM ( each group). * versus respective LPS groups; # versus normal control. LVDP (left ventricular developed pressure).
