Green Tea Attenuates Oxidative Stress and Downregulates the Expression of Angiotensin II AT1 Receptor in Renal and Hepatic Tissues of Streptozotocin-Induced Diabetic Rats
Figure 7
Immunohistochemical localization of AT1 receptor expression in the liver of normal control (a), diabetic control (b), and green-tea-treated diabetic (c) rats. Liver sections were treated with the polyclonal anti-AT1 receptor antibody and counterstained with hematoxylin as detailed in Materials and Methods. In both (a) and (c), moderate AT1 receptor labeling was selectively observed among hepatocytes arranged around the central vein (CV) within hepatic lobules. In (b), AT1 receptor labeling with higher intensity was observed among hepatocytes as well as bile ducts and vessels in portal tracts (arrowheads). No specific labeling was observed in liver sections labeled with the anti-AT1 antibody preabsorbed with an AT1 octapeptide/BSA complex (d). Images are representative of four different samples for each rat group. , ×100.
