In Vitro and In Vivo Genotoxicity Assessment of Aristolochia manshuriensis Kom.

Table 1

Chemicals used as positive controls for each tester strain with or without metabolic activation system (rat liver S9 mix).

Strain	Without S9 mix		With S9 mix
	Positive control^a	Dose (μg/plate)	Positive control^a	Dose (μg/plate)
Salmonella typhimurium
TA100	AF-2	0.01	2-AA	1.0
TA1535	SA	0.5	2-AA	2.0
TA98	AF-2	0.1	2-AA	0.5
TA1537	9-AA	80.0	2-AA	2.0
Escherichia coli
WP2uvrA	AF-2	0.01	2-AA	10.0

^aAF-2: Furylfuramide; SA: sodium azide; 9-AA: 9-aminoacridine hydrochloride hydrate; 2-AA: 2-aminoanthracene.