Polyphenol-Rich Fraction of Brown Alga Ecklonia cava Collected from Gijang, Korea, Reduces Obesity and Glucose Levels in High-Fat Diet-Induced Obese Mice

Figure 5

Effect of CA and G-CA extracts on inflammatory gene expression. Three weeks after beginning a high-fat diet, C57BL6 mice were orally administered CA or G-CA extract (200 mg/kg body weight) or PBS daily for 8 weeks. TNFα, IL-1β, and F4/80 mRNA levels were measured in epididymal fat pads. Values are expressed as fold change compared with the NC group. Values are mean ± SE. NC: untreated, normal chow diet; PBS: PBS-treated, high-fat diet (HFD); CA: CA-treated, HFD; and G-CA: G-CA-treated, HFD. ^∗𝑃<0.05, ^∗∗𝑃<0.01 versus NC group; ^#𝑃<0.05, ^##𝑃<0.01 versus PBS-HFD group; ^$𝑃<0.05 versus CA-HFD.