Protective Effects of Corni Fructus against Advanced Glycation Endproducts and Radical Scavenging

Table 1

AGE-inhibiting and DPPH radical-scavenging activities of the fractions from Corni Fructus extract.

Sample	Major constituents	AGE-inhibiting activity (%)		DPPH radical-scavenging activity (%)
		12.5 μg/mL	25 μg/mL	1 μg/mL	2 μg/mL
Fr. 4-74	Mix^a	10.3±1.0	12.6±8.2	8.4±0.5	14.4±0.8
Fr. 4-56	Mix^a	14.7±0.6	25.7±2.8	12.6±0.6	15.7±1.1
Fr. 4-65	Mix^a	−10.1±9.0	31.9±1.8	20.3±0.3	41.0±1.1
Fr. 4-53	Mix^a + polymeric proanthocyanidins	11.9±6.0	38.6±1.3	21.1±0.6	38.4±0.3
Fr. 4-54	Mix^a + polymeric proanthocyanidins	20.9±6.0	35.7±0.9	21.2±0.9	41.7±0.9
Fr. 4-75	Quercetin glucuronide	8.9±4.0	55.3±5.2	22.9±1.3	48.7±0.6
Fr. 4-64	p-Coumaric acid	14.6±10.6	32.4±7.5	23.6±1.6	39.5±1.3
Fr. 4-52	Mix^a	20.3±1.7	50.0±1.8	24.1±0.6	37.2±0.4
Fr. 4-51	Mix^a + polymeric proanthocyanidins	8.8±3.8	35.2±5.5	24.5±1.5	39.0±1.2
Fr. 4-76	Mix^a	33.3±5.8	72.3±1.8	25.7±1.1	48.0±0.9
Fr. 4-55	Cornuside	13.0±2.4	50.2±1.0	28.3±0.5	51.1±0.3
Fr. 4-63	Caffeic acid + polymeric proanthocyanidins	21.2±4.7	69.6±0.8	28.9±0.3	67.1±0.1
Fr. 4-62	Mix^a + polymeric proanthocyanidins	27.3±6.1	73.0±0.7	35.3±0.3	63.7±0.6
Fr. 4-71	Polymeric proanthocyanidins	41.8±2.9	76.1±1.6	35.6±1.3	64.1±2.3
Fr. 4-72	Mix^a + polymeric proanthocyanidins	40.5±2.6	80.5±1.8	39.6±0.9	68.2±0.5
Fr. 4-8	Polymeric proanthocyanidins	51.3±1.4	85.1±0.3	44.7±0.8	66.1±1.2
Fr. 4-9	Ellagitannins + polymeric proanthocyanidins	75.0±1.8	86.0±0.5	47.3±0.4	70.8±1.8
Corni Fructus extract		9.2±5.2	12.8±0.5	2.8±1.1	5.9±1.4
Morroniside		5.9±2.1	−0.2±3.1	3.3±0.3	2.1±1.1
Loganin		4.0±2.1	−0.6±2.4	1.5±2.2	−0.9±1.6
7-O-Galloyl-D-sedoheptulose		48.2±3.3	61.9±3.7	36.5±0.7	59.6±0.7
Trolox		23.2±2.7	34.1±2.1	33.8±0.5	60.7±1.0
Aminoguanidine		−0.2±1.5	8.6±3.0	5.6±2.1	0.8±3.6

^aMixture of low molecular weight compounds.