Phytochemical Analysis and Antimicrobial, Antinociceptive, and Anti-Inflammatory Activities of Two Chemotypes of Pimenta pseudocaryophyllus (Myrtaceae)

Figure 1

EE_M antinociceptive effect in the abdominal contortion model induced by acetic acid (1.2% v/v, i.p.) in mice previously treated with EE_M (2000, 1000, and 500 mg kg⁻¹, v.o). Vehicle (CMC + propylene glycol) 10 mL kg⁻¹, v.o. Indomethacin was used as positive control (10 mg kg⁻¹, v.o). Each column shows the mean (±SEM) of number of contortions in percentages relative to control (vehicle). *Indicates the significance level compared to the control group (vehicle). 𝑛=10 mice. *𝑃<0.05, ***𝑃<0.001.