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Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 426215, 22 pages
http://dx.doi.org/10.1155/2012/426215
Review Article

Systematic Review on the Efficacy and Safety of Herbal Medicines for Vascular Dementia

School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong

Received 15 January 2011; Revised 20 April 2011; Accepted 27 May 2011

Academic Editor: Andrew Scholey

Copyright © 2012 Sui Cheung Man et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Quinn, “Vascular dementia,” Journal of the American Medical Directors Association, vol. 4, no. 6, pp. S155–S161, 2003. View at Publisher · View at Google Scholar · View at Scopus
  2. F. E. de Leeuw and J. van Gijn, “Vascular dementia,” Practical Neurology, vol. 3, no. 2, pp. 86–91, 2003. View at Scopus
  3. K. A. Jellinger, “The pathology of “vascular dementia”: a critical update,” Journal of Alzheimers Disease, vol. 14, no. 1, pp. 107–123, 2008. View at Scopus
  4. G. C. Román, “Vascular dementia: distinguishing characteristics, treatment, and prevention,” Journal of the American Geriatrics Society, vol. 51, no. 5, pp. S296–S304, 2003. View at Scopus
  5. F. Hentschel, T. Supprian, and L. Frölich, “Alzheimer's disease versus vascular dementia—dichotomy or interaction?” Fortschritte der Neurologie Psychiatrie, vol. 73, no. 6, pp. 317–326, 2005. View at Publisher · View at Google Scholar
  6. M. J. Schneck, “Vascular dementia,” Topics in Stroke Rehabilitation, vol. 15, no. 1, pp. 22–26, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. R. Moretti, P. Torre, R. M. Antonello, and G. Cazzato, “Behavioral alterations and vascular dementia,” Neurologist, vol. 12, no. 1, pp. 43–47, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. K. A. Swanson and R. M. Carnahan, “Dementia and comorbidities: an overview of diagnosis and management,” Journal of Pharmacy Practice, vol. 20, no. 4, pp. 296–317, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. B. Schneider, K. Maurer, and L. Frölich, “Dementia and suicide,” Fortschritte der Neurologie Psychiatrie, vol. 69, no. 4, pp. 164–169, 2001. View at Publisher · View at Google Scholar
  10. R. N. Kalaria, G. E. Maestre, R. Arizaga et al., “Alzheimer's disease and vascular dementia in developing countries: prevalence, management, and risk factors,” The Lancet Neurology, vol. 7, no. 9, pp. 812–826, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. R. Kalaria, “Similarities between Alzheimer's disease and vascular dementia,” Journal of the Neurological Sciences, vol. 203-204, pp. 29–34, 2002. View at Publisher · View at Google Scholar · View at Scopus
  12. C. McVeigh and P. Passmore, “Vascular dementia: prevention and treatment,” Clinical Interventions in Aging, vol. 1, no. 3, pp. 229–235, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. M. J. Dong, B. Peng, X. T. Lin, J. Zhao, Y. R. Zhou, and R. H. Wang, “The prevalence of dementia in the People's Republic of China: a systematic analysis of 1980–2004 studies,” Age and Ageing, vol. 36, no. 6, pp. 619–624, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. C. K. Andersen, J. Søgaard, E. Hansen et al., “The cost of dementia in Denmark: the Odense study,” Dementia and Geriatric Cognitive Disorders, vol. 10, no. 4, pp. 295–304, 1999. View at Publisher · View at Google Scholar · View at Scopus
  15. J. Hill, H. Fillit, S. N. Shah, M. C. del Valle, and R. Futterman, “Patterns of healthcare utilization and costs for vascular dementia in a community-dwelling population,” Journal of Alzheimer's Disease, vol. 8, no. 1, pp. 43–50, 2005. View at Scopus
  16. R. Moretti, P. Torre, R. M. Antonello, C. Vilotti, and G. Pizzolato, “New treatment options for vascular dementia,” Aging Health, vol. 3, no. 2, pp. 209–222, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. D. Zekry, “Is it possible to treat vascular dementia?” Frontiers of Neurology and Neuroscience, vol. 24, pp. 95–106, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. A. Baskys and A. C. Hou, “Vascular dementia: pharmacological treatment approaches and perspectives,” Clinical Interventions in Aging, vol. 2, no. 3, pp. 327–335, 2007. View at Scopus
  19. L. Pantoni, “Treatment of vascular dementia: evidence from trials with non-cholinergic drugs,” Journal of the Neurological Sciences, vol. 226, no. 1-2, pp. 67–70, 2004. View at Publisher · View at Google Scholar · View at Scopus
  20. G. Sorrentino, R. Migliaccio, and V. Bonavita, “Treatment of vascular dementia: the route of prevention,” European Neurology, vol. 60, no. 5, pp. 217–223, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. B. C. Stephan and C. Brayne, “Vascular factors and prevention of dementia,” International Review of Psychiatry, vol. 20, no. 4, pp. 344–356, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. N. Perry, G. Court, N. Bidet, J. Court, and E. Perry, “European herbs with cholinergic activities: potential in dementia therapy,” International Journal of Geriatric Psychiatry, vol. 11, no. 12, pp. 1063–1069, 1996. View at Publisher · View at Google Scholar · View at Scopus
  23. E. Yarnell, “Lemonbalm: humble but potent herb,” Alternative and Complementary Therapies, vol. 4, pp. 417–419, 1998.
  24. B. V. Manyam, “Dementia in Ayurveda,” Journal of Alternative and Complementary Medicine, vol. 5, no. 1, pp. 81–88, 1999. View at Scopus
  25. R. Upton, Ashwagandha Root. Withania Somnifera. Analytical, Quality Control and Therapeutic Monograph, American Herbal Pharmacopoeia and Therapeutic Compendium, 200.
  26. M. J. Howes, N. S. Perry, and P. J. Houghton, “Plants with traditional uses and activities, relevant to the management of Alzheimer's disease and other cognitive disorders,” Phytotherapy Research, vol. 17, no. 1, pp. 1–18, 2003. View at Publisher · View at Google Scholar · View at Scopus
  27. H. Chang and P. P. But, Pharmacology and Applications of Chinese Materia Medica, vol. 2, World Scientific, Singapore, 1987.
  28. D. Kenner and Y. Requena, Botanical Medicine: A European Professional Perspective, Paradigm, Brookline, Mass, USA, 1996.
  29. F. Boughon, “Herbs for the elderly,” Australian Journal of Medical Herbalism, vol. 10, pp. 51–60, 1998.
  30. S. Zbinden and C. Seiler, “Phytotherapy in cardiovascular medicine,” Therapeutische Umschau, vol. 59, no. 6, pp. 301–306, 2002. View at Scopus
  31. V. Klusa, S. Germane, M. Nöldner, and S. S. Chatterjee, “Hypericum extract and hyperforin: memory-enhancing properties in rodents,” Pharmacopsychiatry, vol. 34, no. 1, pp. S61–S69, 2001. View at Scopus
  32. W. Y. Tam, P. Chook, M. Qiao et al., “The efficacy and tolerability of adjunctive alternative herbal medicine (Salvia miltiorrhiza and Pueraria lobata) on vascular function and structure in coronary patients,” Journal of Alternative and Complementary Medicine, vol. 15, no. 4, pp. 415–421, 2009. View at Publisher · View at Google Scholar · View at Scopus
  33. J. Cai, F. Zhou, and J. Du, “Effects of glossy privet fruit on neural cell apoptosis in the cortical parietal lobe and hippocampal CA1 region of vascular dementia rats,” Neural Regeneration Research, vol. 3, no. 11, pp. 1192–1196, 2008. View at Scopus
  34. K. Cho, K. Noh, W. Jung et al., “A preliminary study on the inhibitory effect of Chunghyul-dan on stroke recurrence in patients with small vessel disease,” Neurological Research, vol. 30, no. 6, pp. 655–658, 2008. View at Publisher · View at Google Scholar · View at Scopus
  35. R. Wang, H. Yan, and X. C. Tang, “Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine,” Acta Pharmacologica Sinica, vol. 27, no. 1, pp. 1–26, 2006. View at Publisher · View at Google Scholar · View at Scopus
  36. S. C. Man, S. S. Durairajan, W. F. Kum et al., “Systematic review on the efficacy and safety of herbal medicines for Alzheimer's disease,” Journal of Alzheimer's Disease, vol. 14, no. 2, pp. 209–223, 2008. View at Scopus
  37. A. Viswanathan, W. A. Rocca, and C. Tzourio, “Vascular risk factors and dementia: how to move forward?” Neurology, vol. 72, no. 4, pp. 368–374, 2009. View at Publisher · View at Google Scholar · View at Scopus
  38. M. E. Murray, D. S. Knopman, and D. W. Dickson, “Vascular dementia: clinical, neuroradiologic and neuropathologic aspects,” Panminerva Medica, vol. 49, no. 4, pp. 197–207, 2007. View at Scopus
  39. American Psychiatric Association, Diagnostic and Statistical Manual of Mental Disorders: DSM-III-R, American Psychiatric Association, Washington, DC, USA, 1987.
  40. American Psychiatric Association, Diagnostic and Statistical Manual of Mental Disorders: DSM-IV, American Psychiatric Association, Washington, DC, USA, 1994.
  41. World Health Organization, The ICD-10 Classification of Mental and Behavioural Disorders : Clinical Descriptions and Diagnostic Guidelines, World Health Organization, Geneva, Switzerland, 1992.
  42. H. C. Chui, J. I. Victoroff, D. Margolin, W. Jagust, R. Shankle, and R. Katzman, “Criteria for the diagnosis of ischemic vascular dementia proposed by the State of California Alzheimer's Disease Diagnostic and Treatment Centers,” Neurology, vol. 42, no. 3 I, pp. 473–480, 1992. View at Scopus
  43. V. C. Hachinski, L. D. Iliff, and E. Zilhka, “Cerebral blood flow in dementia,” Archives of Neurology, vol. 32, no. 9, pp. 632–637, 1975.
  44. G. C. Roman, T. K. Tatemichi, T. Erkinjuntti et al., “Vascular dementia: diagnostic criteria for research studies: report of the NINDS-AIREN International Workshop,” Neurology, vol. 43, no. 2, pp. 250–260, 1993. View at Scopus
  45. M. F. Folstein, S. E. Folstein, and P. R. McHugh, “'Mini mental state'. A practical method for grading the cognitive state of patients for the clinician,” Journal of Psychiatric Research, vol. 12, no. 3, pp. 189–198, 1975. View at Publisher · View at Google Scholar · View at Scopus
  46. S. Katz, “Activities of daily living scale,” Home Health Care Services Quarterly, vol. 25, no. 1-2, pp. 13–31, 2006.
  47. N. Tsai and Z. X. Gao, “Validity of Hasegawa's dementia scale for screening dementia among aged Chinese,” International Psychogeriatrics, vol. 1, no. 2, pp. 145–152, 1989. View at Scopus
  48. W. Zhang, T. Leonard, F. Bath-Hextall et al., “Chinese herbal medicine for atopic eczema,” Cochrane Database of Systematic Reviews, no. 3, 2007.
  49. D. Moher, K. F. Schulz, and D. G. Altman, “The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomised trials,” Lancet, vol. 357, no. 9263, pp. 1191–1194, 2001. View at Publisher · View at Google Scholar · View at Scopus
  50. D. Moher, K. F. Schulz, and D. G. Altman, “The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomised trials,” Clinical Oral Investigations, vol. 7, no. 1, pp. 2–7, 2003. View at Scopus
  51. C. Q. Zhang, Y. L. Jin, and L. J. Zhao, “Clinical study on Jian Nao Tong Luo Jiao Nang in the treatment of vascular dementia,” Chinese Journal of Information on Traditional Chinese Medicine, vol. 8, pp. 51–52, 2001.
  52. F. J. Wang, S. J. Lu, and Z. Dong, “Clinical study on Yi Zhi Tong Luo Jiao Nang in the treatment of vascular dementia,” Modern Journal of Integrated Chinese Traditional and Western Medicine, vol. 11, pp. 295–297, 2002.
  53. X. F. Guo, Y. B. Yan, Y. H. Zhao, and C. X. Sun, “Clinical study on Bu Nao Tong Qiao Fang in the treatment of vascular dementia,” Journal of Traditional Chinese Medicine, vol. 44, p. 931, 2003.
  54. M. L. Hong, G. D. Hou, L. S. Hong, et al., “Clinical study on Shou Xing Jiao Nang in the treatment of vascular dementia,” Hubei Journal of Traditional Chinese Medicine, vol. 24, pp. 3–5, 2002.
  55. Z. G. Luo, W. Q. Zhou, P. Gao, and L. Cui, “Clinical study on treatment of senile vascular dementia with Shen Ma Yi Zhi capsule,” Journal of Traditional Chinese Medicine, vol. 42, pp. 470–473, 2001.
  56. F. W. Wang, Z. K. Wang, N. Jiang, et al., “Clinical study on the effect of shenlong decoction on vascular dementia,” Academic Journal of PLA Postgraduate Medical School, vol. 26, pp. 93–95, 2005.
  57. H. He, “Clinical study on Yi Shen Hua Zhuo Qu Yu Zhu Tan Fa in the treatment of vascular dementia,” Chinese Journal of Information on Traditional Chinese Medicine, vol. 14, pp. 60–61, 2007.
  58. Q. Yan, “Clinical study on Chinese medicine in the treatment of vascular dementia,” Journal of Sichuan of Traditional Medicine, vol. 25, pp. 41–42, 2007.
  59. H. Ji, “Clinical observation on the treatment of vaseular dementia by Danggui Shaoyao powder,” Shanxi Journal of Traditional Chinese Medicine, vol. 16, pp. 10–11, 2000.
  60. H. J. Liu, J. Qin, W. Liang, and Y. Q. Huang, “Clinical study on Hua Tuo Zai Zao Wan in the treatment of vascular dementia,” Chinese Traditional and Herbal Drugs, vol. 36, pp. 1052–1054, 2005.
  61. L. J. Li, L. T. Zhang, Y. M. Li, and D. S. Shang, “Clinical study on Tong Mai Yi Zhi Wan in the treatment of vascular dementia,” Journal of Hubei College of Traditional Chinese Medicine, vol. 8, pp. 48–49, 2006.
  62. F. W. Wang, N. Jiang, Z. Q. Tong et al., “Clinical study on shenlong tang for improving neurological impairment in patients with vascular dementia,” Chinese Journal of Clinical Rehabilitation, vol. 8, no. 4, pp. 679–681, 2004. View at Scopus
  63. Y. Wan and Y. F. Wang, “Clinical study on effect of fucongtang in treating vascular dementia,” Hebei Medicine, vol. 4, pp. 24–27, 1998.
  64. G. P. Zhou and X. Yi, “Clinical study on Yi Nao Ling in the treatment of vascular dementia,” Shandong Journal of Traditional Chinese Medicine, vol. 20, pp. 14–15, 2001.
  65. C. Z. Liu, L. H. Zhou, and Z. Shui, “Clinical study on Tong Qiao Huo Xue Tang He Bu Yang Huan Wu Tang in the treatment of vascular dementia,” Journal of Traditional Chinese Medicine, vol. 43, pp. 526–527, 2002.
  66. S. Z. Yu, G. S. Zheng, Q. Shi, L. X. Ai, and R. R. Cheng, “Clinical study on Fucong Xiangye for treatment of 72 cases of vascular dementia,” Journal of Traditional Chinese Medicine, vol. 45, pp. 424–425, 2004.
  67. Q. Gao, “Clinical study on Shu Mai Yi Nao Jiao Nang in the treatment of vascular dementia,” Forum on Traditional Chinese Medicine, vol. 21, pp. 14–16, 2006.
  68. W. H. Mou, “Clinical observation of Yizhi decoction treating senile vascular dementia,” Liaoning Journal of Traditional Chinese Medicine, vol. 33, p. 1607, 2006.
  69. W. Y. Zhang and Z. P. Lu, “Clinical study on effect of Bushenjiannao decoction in vascular dementia patients,” Chinese Journal of Integrative Medicine on Cardio-/Cerebrovascular Disease, vol. 4, pp. 680–681, 2006.
  70. Z. Y. Chang, Q. C. Qiao, Y. H. Zhang, and Q. Z. Qiao, “Clinical study on Qi Hong Kou Fu Ye in the treatment of vascular dementia,” Chinese Remedies & Clinics, vol. 8, pp. 240–241, 2008.
  71. G. T. Liu, “Changes of intellectual status, hemorheology and blood lipids in patients with vascular dementia and the interventional effects of Bushen Yinao capsule,” Chinese Journal of Clinical Rehabilitation, vol. 9, no. 20, pp. 50–51, 2005. View at Scopus
  72. J. Cai, J. Du, J. S. Huang, and Q. C. Lin, “Clinical effect of the principle of tonifying-kidney, invigorating-spleen, nourishing and activating-blood on patients with vascular dementia,” Chinese Journal of Clinical Rehabilitation, vol. 7, no. 31, pp. 4251–4253, 2003. View at Scopus
  73. X. L. Liao, K. Y. Chen, Z. R. Zheng, H. Liu, and K. Y. Zheng, “Clinical study of Shoulingjiannao capsule in improvement of brain function for patients with vascular dementia,” Chinese Journal of Clinical Rehabilitation, vol. 8, no. 1, pp. 112–114, 2004. View at Scopus
  74. W. Liu and Z. Y. Chen, “Clinical study of shulzhltong capsule in treating senile vascular dementia,” China and Foreign and Medical Journal, vol. 3, pp. 18–20, 2005.
  75. X. J. Tang, Y. R. Lao, Z. M. Yang, P. X. Huang, and X. D. Luo, “Clinical observation on modified bushen huoxie decoction for the treatment of vascular dementia,” Journal of Guangzhou University of Traditional Chinese Medicine, vol. 22, pp. 426–429, 2005.
  76. H. Shi and H. M. Wang, “Clinical effects observation of invigorating kidney and promoting blood flow method on treating vascular dementia,” Tianjin Journal of Traditional Chin Medicine, vol. 23, pp. 200–202, 2006.
  77. L. Cui, F. Liu, and M. D. Guo, “Clinical study on Shuang Shen Cu Zhi Ke Li in the treatment of vascular dementia,” China Journal of Experimental Traditional Medical Formulae, vol. 13, pp. 64–65, 2007.
  78. Y. P. Li and Z. D. Shi, “Clinical study on Bu Yang Huan Wu Tang in the treatment of vascular dementia,” Journal of Hubei College of Traditional Chinese Medicine, vol. 1, pp. 17–18, 1999.
  79. Y. Zhao, W. Zhou, and P. Gao, “Clinical study on effect of xianlong capsule on senile vascular dementia,” Chinese Journal of Integrated Traditional and Western Medicine, vol. 19, no. 10, pp. 585–588, 1999. View at Scopus
  80. W. M. Yang, W. J. Lu, M. X. Han, et al., “Clinical research of Zhinao capsule on 60 cases with vascular dementia,” China Journal of Experimental Traditional Medical Formulae, vol. 8, pp. 48–51, 2002.
  81. J. Cai, J. Du, J. S. Huang, Q. C. Lin, and K. J. Chen, “Clinical observation of Kangxin capsule on the influence of vascular dementia,” Chinese Journal of Gerontology, vol. 23, pp. 482–484, 2003.
  82. X. L. Cao, X. X. Song, Z. Q. Hu, T. Mei, J. Zhou, and F. R. Zhang, “Clinical study on treatment of vascular dementia with congsheng capsule,” Journal of Emergency in Traditional Chinese Medicine, vol. 11, pp. 80–81, 2002.
  83. S. Y. Wu, S. Q. Fang, and H. Liang, “Clinical study on Cong Rong Zong Dai Jiao Nang in the treatment of vascular dementia,” Fujian Journal of Traditional Chinese Medicine, vol. 35, pp. 3–4, 2004.
  84. L. P. Chen, F. W. Wang, J. J. Jia, and A. J. Hao, “Effects of shenlong decoction on life quality of the aged patients with cerebral vascular dementia,” Medical Journal of Chinese People's Liberation Army, vol. 32, pp. 866–868, 2007.
  85. X. M. Jin, L. Li, L. X. Lian, and Z. H. Song, “Clinical investigation of Jiannaoyizhi capsule to improving vascular dementia sufferer on nerve function damage,” Chinese Archives of Traditional Chinese Medicine, vol. 25, pp. 1657–1659, 2007.
  86. Y. Y. Feng, J. X. Zhang, and X. D. Ding, “Clinical study on Yi Zhi Tang in the treatment of vascular dementia,” Study Journal of Traditional Chinese Medicine, vol. 23, pp. 520–522, 2005.
  87. J. C. Morris, “The clinical dementia rating (CDR): current version and scoring rules,” Neurology, vol. 43, no. 11, pp. 2412–2414, 1993. View at Scopus
  88. J. Z. Tian, X. H. Ming, W. T. Jin, et al., “Criteria for the diagnosis, the differentiation of syndrome and the evaluation of efficacy of vascular dementia for research studies,” Chinese Journal of Gerontology, vol. 22, pp. 329–331, 2002.
  89. G. G. Fillenbaum and M. A. Smyer, “The development, validity, and reliability of the OARS multidimensional functional assessment questionnaire,” Journals of Gerontology, vol. 36, no. 4, pp. 428–434, 1981. View at Scopus
  90. H. Lu, Y. Y. Wang, F. Chen, Y. Wu, D. H. Gai, and Z. Cui, “Clinical observation on 50 cases of cerebrovascular dementia treated with Shentong capsule,” J TCM, vol. 41, pp. 290–291, 2000.
  91. Q. H. Huang, Q. M. Li, and Z. H. Tan, “Clinical study on naohuandan capsule in the treatment of senile dementia,” Practical Geriatrics, vol. 16, pp. 301–304, 2002.
  92. W. H. Jia, X. N. Ding, Z. M. Xu, and M. P. Jie, “Clinical study on the Luoshukang Capsule in the treatment of vascular dementia [Luoshukang Jiao Nang Zhi Liao Xue Guan Xing Chi Dai De Lin Chuang Yan Jiu],” Guang Ming Zhong Yi, vol. 18, pp. 20–22, 2003.
  93. W. P. Cheng, L. Ma, H. Toshihide, and Q. W. Wang, “Treatment of Vascular Dementia by Naozhitong Capsule: A Clinical Observation of 18 Cases,” J New CM, vol. 36, pp. 16–18, 2004.
  94. S. H. Shen and J. Du, “The therapeutic effects of Kidney-Tonifying and spleen-invigorating, blood-nourishing and quickening the blood formula on vascular dementia in the pattern of Kidney deficiency and blood stasis,” J TCM U HUNAN, vol. 24, pp. 41–50, 2004.
  95. F. W. Wang, N. Jiang, Z. Q. Tong et al., “Clinical study on Shenlong Tang for improving neurological impairment in patients with vascular dementia,” CHIN J CLIN REHAB, vol. 8, pp. 679–681, 2004.
  96. J. Wang, Q. X. Chen, Y. Hai et al., “Clinical Study of Huitianpian in the treatment of vascular dementia,” Chinese Archieves of Traditional Chinese Medicine, vol. 22, no. 9, pp. 1691–1694, 2004.
  97. Y. J. Zhao, “A Summary on 50 Cases of Vascular Dementia Treated by Jiannao Qingxin Decoction,” HUNAN J TRAD CHIN MED, vol. 6, pp. 8–10, 2004.
  98. J. Wang, Q. W. Chen, and L. Bai, “Clinical study of Jiannaocongming decoction in the treatment of vascular dementia [Jiannaocongming Kou Fu Ye Zhi Liao Xue Guan Xing Chi Dai De Lin Chuang Yan Jiu],” LIAONING J TCM, vol. 32, pp. 3–5, 2005.
  99. L. L. Wang, P. Z. Ying, and X. M. Wang, “Clinical efficacy of Tongxinluo capsule in the treatment of vascular dementia,” CHIN J DIFFIC COMPL CAS, vol. 4, pp. 260–262, 2005.
  100. Z. Y. Wang, “Clinical observation of Buyanghuanwutang in the treatment of vascular dementia [Buyanghuanwutang jia xi yao zhi liao xue guan xing chi dai liao xiao guan cha],” J SICHUAN TRAD CHIN MED, vol. 23, pp. 40–41, 2005.
  101. J. Y. Zhou, T. Liu, and C. C. Sun, “Clinical Study on “Yiqi Fuzhi Granule” in Treating Vascular Dementia,” SHANGHAI J TRAD CHIN MED, vol. 39, pp. 11–13, 2005.
  102. W. P. Hao, F. H. Ye, and L. Z. Li, “Clinical observations of Tongxingluo capsule in the treatment of vascular dementia,” J CLIN PSYCHOSOM DIS, vol. 12, pp. 424–425, 2006.
  103. C. S. Li, J. Li, X. H. Guan et al., “Clinical study of Shouwuyizhi capsule in the treatment of vascular dementia,” CHIN J GERI, vol. 28, pp. 369–371, 2008.
  104. Z. Q. Quan, et al., “Progress on the TCM diagnosis and treatment of vascular dementia,” Acta Chinese Medicine and Pharmacology, vol. 5, p. 52, 1996.
  105. Guidance Principle of Clinical Study on New Drug of Traditional Chinese Medicine, vol. 2, Ministry of Health of the People’s Republic of China, Beijing, China.
  106. R. J. Fu, “TCM diagnostic criteria, differentiation and outcome measures on senile dementia,” Journal of Traditional Chinese Medicine, vol. 2, p. 56, 1991.
  107. W. Q. Zhou, “Protocol for the selection of anti-aging herbal medicine and the corresponding outcome measures,” Chinese Journal of Integrated and Traditional and Western Medicine, vol. 11, p. 683, 1986.
  108. P. X. Huang and M. C. Liu, TCM manual for neurological diseases, People’s Medical Publishing House, Beijing, China, 2000.
  109. X. D. Wang, Diagnostic manual for geriatrics, Peking Union Medical College Press, Beijing, China, 1997.
  110. S. Dharmananda, “Alzheimer's disease: treatment with Chinese herbs,” 1996.
  111. L. Xiong, Z. Y. Fang, X. N. Tao, M. Bai, and G. Feng, “Effect and mechanism of ligustrazine on Th1/Th2 cytokines in a rat asthma model,” American Journal of Chinese Medicine, vol. 35, no. 6, pp. 1011–1020, 2007. View at Publisher · View at Google Scholar · View at Scopus
  112. D. Cai, “Effectiveness and safety of xiaoshuanchangrong (XSCR) capsule for the treatment of patients who have suffered from a stroke,” Fudan University Identifier: NCT00710164, 2008.
  113. S. Ling, L. Nheu, A. Dai, Z. Guo, and P. Komesaroff, “Effects of four medicinal herbs on human vascular endothelial cells in culture,” International Journal of Cardiology, vol. 128, no. 3, pp. 350–358, 2008. View at Publisher · View at Google Scholar · View at Scopus
  114. Y. C. Chan, M. F. Wang, Y. C. Chen, D. Y. Yang, M. S. Lee, and F. C. Cheng, “Long-term administration of Polygonum multiflorum Thunb. reduces cerebral ischemia-induced infarct volume in gerbils,” American Journal of Chinese Medicine, vol. 31, no. 1, pp. 71–77, 2003. View at Publisher · View at Google Scholar · View at Scopus
  115. S. P. Ip, A. S. Tse, M. K. Poon, K. M. Ko, and C. Y. Ma, “Antioxidant activities of Polygonum multiflorum Thunb; in vivo and in vitro,” Phytotherapy Research, vol. 11, no. 1, pp. 42–44, 1997. View at Publisher · View at Google Scholar · View at Scopus
  116. M. Y. Um, W. H. Choi, J. Y. Aan, S. R. Kim, and T. Y. Ha, “Protective effect of Polygonum multiflorum Thunb on amyloid β-peptide 25-35 induced cognitive deficits in mice,” Journal of Ethnopharmacology, vol. 104, no. 1-2, pp. 144–148, 2006. View at Publisher · View at Google Scholar · View at Scopus
  117. Y. C. Chan, F. C. Cheng, and M. F. Wang, “Beneficial effects of different Polygonum multiflorum Thunb. Extracts on memory and hippocampus morphology,” Journal of Nutritional Science and Vitaminology, vol. 48, no. 6, pp. 491–497, 2002. View at Scopus
  118. M. J. Chiu, “Efficacy and safety study of DCB-AD1 in patients with mild to moderate Alzheimer’s disease,” National Taiwan University Hospital Identifier: NCT00154635, 2005.
  119. Z. J. Zhang, “Therapeutic effects of herbal extracts and constituents in animal models of psychiatric disorders,” Life Sciences, vol. 75, no. 14, pp. 1659–1699, 2004. View at Publisher · View at Google Scholar · View at Scopus
  120. Q. Zhang, Z. Chang, J. Yang, and Q. Wang, “Antiatherogenic property of triterpenoids-enriched extract from the aerial parts of Salvia miltiorrhiza,” Phytotherapy Research, vol. 22, no. 8, pp. 1040–1045, 2008. View at Publisher · View at Google Scholar · View at Scopus
  121. C. J. Lao, J. G. Lin, J. S. Kuo et al., “Effect of Salvia Miltiorrhiza Bunge on cerebral infarct in ischemia-reperfusion injured rats,” American Journal of Chinese Medicine, vol. 31, no. 2, pp. 191–200, 2003. View at Publisher · View at Google Scholar · View at Scopus
  122. G. Zhang, A. Liu, Y. Zhou, X. San, T. Jin, and Y. Jin, “Panax ginseng ginsenoside-Rg2 protects memory impairment via anti-apoptosis in a rat model with vascular dementia,” Journal of Ethnopharmacology, vol. 115, no. 3, pp. 441–448, 2007. View at Publisher · View at Google Scholar
  123. Y. C. Huang, C. T. Chen, S. C. Chen et al., “A natural compound (Ginsenoside Re) isolated from Panax ginseng as a novel angiogenic agent for tissue regeneration,” Pharmaceutical Research, vol. 22, no. 4, pp. 636–646, 2005. View at Publisher · View at Google Scholar · View at Scopus
  124. S. T. Lee, K. Chu, J. Y. Sim, J. H. Heo, and M. Kim, “Panax ginseng enhances cognitive performance in Alzheimer disease,” Alzheimer Disease and Associated Disorders, vol. 22, no. 3, pp. 222–226, 2008. View at Publisher · View at Google Scholar · View at Scopus
  125. W. P. Liao, L. Chen, Y. H. Yi et al., “Study of antiepileptic effect of extracts from Acorus tatarinowii schott,” Epilepsia, vol. 46, supplement 1, pp. 21–24, 2005. View at Scopus
  126. W. Wang, F. Sun, Y. An et al., “Morroniside protects human neuroblastoma SH-SY5Y cells against hydrogen peroxide-induced cytotoxicity,” European Journal of Pharmacology, vol. 613, no. 1–3, pp. 19–23, 2009. View at Publisher · View at Google Scholar · View at Scopus
  127. C. Li, J. Yang, S. Yu et al., “Triterpenoid saponins with neuroprotective effects from the roots of Polygala tenuifolia,” Planta Medica, vol. 74, no. 2, pp. 133–141, 2008. View at Publisher · View at Google Scholar · View at Scopus
  128. R. Naito and C. Tohda, “Characterization of anti-neurodegenerative effects of polygala tenuifolia in abeta(25-35)-treated cortical neurons,” Biological and Pharmaceutical Bulletin, vol. 29, pp. 1892–1896, 2006.
  129. B. S. Koo, W. C. Lee, Y. C. Chang, and C. H. Kim, “Protective effects of alpinae Oxyphyllae fructus (Alpinia oxyphylla MIQ) water-extracts on neurons from ischemic damage and neuronal cell toxicity,” Phytotherapy Research, vol. 18, no. 2, pp. 142–148, 2004. View at Publisher · View at Google Scholar · View at Scopus
  130. X. Yu, L. An, Y. Wang, H. Zhao, and C. Gao, “Neuroprotective effect of Alpinia oxyphylla Miq. Fruits against glutamate-induced apoptosis in cortical neurons,” Toxicology Letters, vol. 144, no. 2, pp. 205–212, 2003. View at Publisher · View at Google Scholar · View at Scopus
  131. F. Zhang, J. Zhang, L. Wang, and D. Mao, “Effects of polygonatum sibiricum polysaccharide on learning and memory in a scopolamine-induced mouse model of dementia,” Neural Regeneration Research, vol. 3, no. 1, pp. 33–36, 2008. View at Scopus
  132. S. M. Lee, M. Y. Yoon, and H. R. Park, “Protective effects of Paeonia lactiflora pall on hydrogen peroxide-induced apoptosis in PC12 cells,” Bioscience, Biotechnology and Biochemistry, vol. 72, no. 5, pp. 1272–1277, 2008. View at Publisher · View at Google Scholar
  133. T. X. Zhang, C. Q. Niu, H. E. Jing, and H. Liu, “Effect of water decoction of the Gastrodia elata BI on vasodilation of rabbit aorta in vitro,” Journal of Clinical Rehabilitative Tissue Engineering Research, vol. 12, no. 20, pp. 3988–3991, 2008. View at Scopus
  134. E. K. Ahn, H. J. Jeon, E. J. Lim, H. J. Jung, and E. H. Park, “Anti-inflammatory and anti-angiogenic activities of Gastrodia elata Blume,” Journal of Ethnopharmacology, vol. 110, no. 3, pp. 476–482, 2007. View at Publisher · View at Google Scholar · View at Scopus
  135. J. H. Liu, Y. M. Bao, J. J. Song, and L. J. An, “Codonopsis pilosula (Franch) Nannf total alkaloids potentiate neurite outgrowth induced by nerve growth factor in PC12 cells,” Acta Pharmacologica Sinica, vol. 24, no. 9, pp. 913–917, 2003.
  136. P. T. H. Julian and G. Sally, “Summarizing effects across studies,” in Cochrane Handbook for Systematic Reviews of Interventions, J. D. Jonathan, P. T. H. Julian, and G. A. Douglas, Eds., pp. 263–275, Wiley, 2008.