A Longitudinal Follow-Up Study of Saffron Supplementation in Early Age-Related Macular Degeneration: Sustained Benefits to Central Retinal Function

Table 1

Demographic and clinical findings at baseline in patients with early AMD.

Patient no.	Age (yr), sex	Acuity	Follow-up duration	Fundus^*	Macular thickness	fERG^§
					(microm)	(no. of responses at B, 3, 6, 9, 12, 15)^¶
1	77, F	0.8	15	Soft drusen, middle subfield	304	4(B), 5(3), 5(6), 5(9), 5(12), 5(15)
2	62, F	0.6	15	Soft drusen, middle subfield	272	6(B), 6(3), 6(6), 6(9), 6(12), 6(15)
3	61, F	0.5	12	Soft drusen, middle subfield	250	5(B), 6(3), 6(6), 6(9), 6(12)
4	63, F	0.7	12	Soft drusen, central and middle subfield	288	5(B), 6(3), 6(6), 6(9), 5(12)
5	75, M	0.7	15	Soft drusen, middle subfield	279	4(B), 5(3), 5(6), 6(9), 6(12), 6(15)
6	85, M	0.8	12	Soft drusen, central and middle subfield	260	5(B), 5(3), 5(6), 5(9), 5(12), 5(15)
7	70, M	0.7	15	Soft drusen, central subfield	280	4(B), 4(3), 4(6), 5(9), 5(12), 5(15)
8	71, M	1.0	12	Soft confluent drusen, middle subfield	254	5(B), 6(3), 6(6), 5(9), 5(12)
9	73, M	1.0	15	Soft drusen, central subfield	294	4(B), 5(3), 5(6), 6(9), 6(12), 6(15)
10	81, F	0.5	6	Soft drusen, middle subfield	251	4(B), 4(3), 4(6)
11	73, M	0.7	15	Soft drusen, central and middle subfield	275	1(B), 5(3), 6(6), 6(9), 6(12)
12	62, F	0.6	15	Soft drusen, middle subfield	297	6(B), 6(3), 6(6), 6(9), 6(12), 6(15)
13	73, M	1.0	15	Soft drusen, hyperpigm., middle subfield	221	4(B), 4(3), 5(6), 5(9), 5(12), 4(15)
14	68, M	0.8	15	Soft confluent drusen, central and middle subfield	242	2(B), 4(3), 4(6), 6(9), 6(12), 5(15)
15	58, M	1.0	6	Soft drusen, middle subfield	280	1(B), 5(3), 5(6)
16	63, M	0.8	15	Soft confluent drusen, hypopigm., middle subfield	278	4(B), 5(3), 5(6), 4(9), 5(12), 5(15)
17	64, F	1.0	15	Soft drusen and hypopigm., middle subfield	264	2(B), 6(3), 6(6), 5(9), 6(12), 6(15)
18	55, M	1.0	15	Soft drusen and hyperpigm., central subfield	295	5(B), 5(3), 6(6), 6(9), 6(12), 5(15)
19	70, F	0.7	15	Soft drusen and hyperpigm., middle subfield	237	2(B), 2(3), 1(6), 3(9), 3(12), 4(15)
20	79, M	0.4	15	Soft drusen and hyperpigm., middle subfield	255	1(B), 1(3), 4(6), 6(9), 6(12), 6(15)
21	70, M	1.0	12	Soft drusen and hyperpigm., central subfield	279	4(B), 5(3), 5(6), 4(9), 4(12)
22	70, M	0.7	15	Soft confluent drusen, central subfield	290	5(B), 5(3), 5(6), 5(9), 5(12), 5(15)
23	85, M	0.3	12	Soft drusen, middle subfield	255	1(B), 2(3), 2(6)
24	71, F	1.0	15	Soft drusen, central and middle subfield	280	4(B), 5(3), 5(6), 6(9), 5(12), 5(15)
25	73, F	1.0	15	Soft drusen and hyperpigm., middle subfield	266	3(B), 5(3), 5(6), 5(9), 5(12), 5(15)
26	71, F	0.6	15	Soft confluent drusen, hypopigm., central subfield	270	6(B), 6(3), 5(6), 5(9), 6(12), 5(15)
27	61, M	0.5	15	Soft confluent drusen, hypopigm., middle subfield	265	2(B), 6(3), 5(6), 6(9), 6(12), 5(15)
28	68, F	0.6	15	Soft confluent drusen., central subfield	293	6(B), 5(3), 5(6), 5(9), 5(12), 5(15)
29	56, F	0.6	12	Soft confluent drusen, middle subfield	277	6(B), 6(3), 6(6), 5(9), 6(12)

^*Macular appearance with reference to drusen type, confluence, and location; RPE abnormalities type and main location¹. Follow-up duration (months). ^§Number of FERG responses that were above noise level (i.e., S/N ratio ≥ 3) at the different modulation depths of the recording protocol; (6) = S/N ratio ≥ 3 at all modulation depths, (5) = S/N ratio < 3 at the lowest modulation depth, (4) = S/N ratio < 3 at the two lowest modulation depths, etc., B: baseline 3, 6, 9, 12, 15 months of supplementation. ^¶Months of follow-up.