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Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 429412, 23 pages
http://dx.doi.org/10.1155/2012/429412
Review Article

Neural Acupuncture Unit: A New Concept for Interpreting Effects and Mechanisms of Acupuncture

1School of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong
2National Institute of Nursing Research, National Institutes of Health, Bethesda, MD 20892, USA
3Department of Forensic and Neurodevelopmental Science, Institute of Psychiatry, King's College London, London, UK

Received 24 September 2011; Revised 30 November 2011; Accepted 1 December 2011

Academic Editor: Toku Takahashi

Copyright © 2012 Zhang-Jin Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. K. Linde, A. Vickers, M. Hondras et al., “Systematic reviews of complementary therapies—an annotated bibliography. Part 1: acupuncture,” BMC Complementary and Alternative Medicine, vol. 1, article 3, 2001. View at Publisher · View at Google Scholar · View at Scopus
  2. J. Park, K. Linde, E. Manheimer et al., “The status and future of acupuncture clinical research,” The Journal of Alternative and Complementary Medicine, vol. 14, no. 7, pp. 871–881, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  3. Z. Q. Zhao, “Neural mechanism underlying acupuncture analgesia,” Progress in Neurobiology, vol. 85, no. 4, pp. 355–375, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  4. F. Zhou, D. Huang, and Y. Xia, “Neuroanatomical basis of acupuncture points,” in Acupuncture Therapy for Neurological Diseases: A Neurobiological View, Y. Xia, G. Wu, X. Cao, et al., Eds., chapter 2, pp. 32–80, Tsinghua University Press, Beijing, China, 2010.
  5. A. C. Ahn, A. P. Colbert, B. J. Anderson et al., “Electrical properties of acupuncture points and meridians: a systematic review,” Bioelectromagnetics, vol. 29, no. 4, pp. 245–256, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  6. S. Lim, “WHO standard acupuncture point locations,” Evidence-Based Complementary and Alternative Medicine, vol. 7, no. 2, pp. 167–168, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  7. P. R. Hu and Z. Y. Zhao, “Regional anatomical study on major acupoints at triple energy meridian of Hand-Shaoyang,” Jinzhou Medical College, no. 3, pp. 1–10, 1980.
  8. C. C. Han, “Acupuncture points histological properties,” in Acupuncture: The Past and The Present, K. C. Huang, Ed., chapter 4, p. 47, Vontage Press, New York, NY, USA, 1996.
  9. G. W. Lu, R. Z. Liang, and J. Q. Xie, “Analysis of peripheral afferent fibers on effect of acupuncture analgesia at Zusanli point,” Science in China, vol. 22, pp. 495–503, 1979.
  10. G. W. Lu, “Characteristics of afferent fiber innervation on acupuncture points zusanli,” The American Journal of Physiology, vol. 245, no. 4, pp. R606–R612, 1983. View at Scopus
  11. A. H. Li, J. M. Zhang, and Y. K. Xie, “Human acupuncture points mapped in rats are associated with excitable muscle/skin-nerve complexes with enriched nerve endings,” Brain Research, vol. 1012, no. 1-2, pp. 154–159, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  12. Z. L. Tao, “The progress of the morphological research on the acupoint,” Zhen Ci Yan Jiu, vol. 14, no. 4, pp. 397–402, 1989. View at Scopus
  13. D. D. Metcalfe, D. Baram, and Y. A. Mekori, “Mast cells,” Physiological Reviews, vol. 77, no. 4, pp. 1033–1079, 1997. View at Scopus
  14. M. Toyoda, T. Makino, M. Kagoura, and M. Morohashi, “Immunolocalization of substance P in human skin mast cells,” Archives of Dermatological Research, vol. 292, no. 8, pp. 418–421, 2000. View at Scopus
  15. D. Zhang, G. Ding, X. Shen et al., “Role of mast cells in acupuncture effect: a pilot study,” Explore, vol. 4, no. 3, pp. 170–177, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  16. M. Yaprak, “The axon reflex,” Neuroanatomy, vol. 7, pp. 17–19, 2008. View at Scopus
  17. P. Holzer, “Neurogenic vasodilatation and plasma leakage in the skin,” General Pharmacology, vol. 30, no. 1, pp. 5–11, 1998. View at Publisher · View at Google Scholar · View at Scopus
  18. G. J. Wang, M. H. Ayati, and W. B. Zhang, “Meridian studies in China: a systematic review,” Journal of Acupuncture and Meridian Studies, vol. 3, no. 1, pp. 1–9, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. Y. Zhao, Q. X. Sun, S. H. Zhang, et al., “Multiple neuropeptides participate in the peripheral information transmission across dermatomes,” Zhen Ci Yan Jiu, vol. 27, no. 4, pp. 298–302, 2002.
  20. D. Y. Cao, H. J. You, Y. Zhao et al., “Involvement of peripheral ionotropic glutamate receptors in activation of cutaneous branches of spinal dorsal rami following antidromic electrical stimulation of adjacent afferent nerves in rats,” Brain Research Bulletin, vol. 72, no. 1, pp. 10–17, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  21. Y. Guo, F. R. Yao, D. Y. Cao et al., “Somatostatin inhibits activation of dorsal cutaneous primary afferents induced by antidromic stimulation of primary afferents from an adjacent thoracic segment in the rat,” Brain Research, vol. 1229, pp. 61–71, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  22. W. Janig, J. D. Levine, and M. Michaelis, “Interactions of sympathetic and primary afferent neurons following nerve injury and tissue trauma,” Progress in Brain Research, vol. 113, pp. 161–184, 1996. View at Scopus
  23. G. Rubin, T. Kaspi, Z. H. Rappaport et al., “Adrenosensitivity of injured afferent neurons does not require the presence of postganglionic sympathetic terminals,” Pain, vol. 72, no. 1-2, pp. 183–191, 1997. View at Publisher · View at Google Scholar · View at Scopus
  24. J. X. Chen and S. X. Ma, “Effects of nitric oxide and noradrenergic function on skin electric resistance of acupoints and meridians,” Journal of Alternative and Complementary Medicine, vol. 11, no. 3, pp. 423–431, 2005.
  25. J. X. Chen, B. O. Ibe, and S. X. Ma, “Nitric oxide modulation of norepinephrine production in acupuncture points,” Life Sciences, vol. 79, no. 23, pp. 2157–2164, 2006.
  26. A. Sato, Y. Sato, A. Suzuki, and S. Uchida, “Reflex modulation of catecholamine secretion and adrenal sympathetic nerve activity by acupuncture-like stimulation in anesthetized rat,” The Japanese Journal of Physiology, vol. 46, no. 5, pp. 411–421, 1996. View at Publisher · View at Google Scholar · View at Scopus
  27. D. F. Bossut, L. S. Leshin, M. W. Stromberg, and P. V. Malven, “Plasma cortisol and beta-endorphin in horses subjected to electro-acupuncture for cutaneous analgesia,” Peptides, vol. 4, no. 4, pp. 501–507, 1983. View at Publisher · View at Google Scholar · View at Scopus
  28. B. Y. Chen and J. Yu, “Relationship between blood radioimmunoreactive beta-endorphin and hand skin temperature during the electro-acupuncture induction of ovulation,” Acupuncture and Electro-Therapeutics Research, vol. 16, no. 1-2, pp. 1–5, 1991. View at Scopus
  29. K. Uvnäs-Moberg, T. Lundeberg, G. Bruzelius, et al., “Vagally mediated release of gastrin and cholecystokinin following sensory stimulation,” Acta Physiologica Scandinavica, vol. 146, no. 3, pp. 349–356, 1992.
  30. X. Guan, X. Liang, and X. Liu, “Acetylcholine and the primary input of acupuncture sensation—influence of peripheral acetylcholine on the role of electroacupuncture analgesia,” Zhen ci Yan Jiu, vol. 15, no. 2, pp. 136–139, 1990 (Chinese). View at Scopus
  31. N. Goldman, M. Chen, T. Fujita et al., “Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture,” Nature Neuroscience, vol. 13, no. 7, pp. 883–888, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  32. S. De Biasi and A. Rustioni, “Glutamate and substance P coexist in primary afferent terminals in the superficial laminae of spinal cord,” Proceedings of the National Academy of Sciences of the United States of America, vol. 85, no. 20, pp. 7820–7824, 1988. View at Scopus
  33. N. E. Lazarov, “Comparative analysis of the chemical neuroanatomy of the mammalian trigeminal ganglion and mesencephalic trigeminal nucleus,” Progress in Neurobiology, vol. 66, no. 1, pp. 19–59, 2002. View at Publisher · View at Google Scholar · View at Scopus
  34. F. J. Diez Guerra, M. Zaidi, P. Bevis, I. MacIntyre, and P. C. Emson, “Evidence for release of calcitonin gene-related peptide and neurokinin A from sensory nerve endings in vivo,” Neuroscience, vol. 25, no. 3, pp. 839–846, 1988. View at Scopus
  35. S. M. Carlton, G. L. Hargett, and E. Richard, “Localization and activation of glutamate receptors in unmyelinated axons of rat glabrous skin,” Neuroscience Letters, vol. 197, no. 1, pp. 25–28, 1995. View at Publisher · View at Google Scholar · View at Scopus
  36. F. Karim, G. Bhave, and R. W. Gereau IIII, “Metabotropic glutamate receptors on peripheral sensory neuron terminals as targets for the development of novel analgesics,” Molecular Psychiatry, vol. 6, no. 6, pp. 615–617, 2001. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  37. S. M. Carlton, S. Zhou, and R. E. Coggeshall, “Localization and activation of substance P receptors in unmyelinated axons of rat glabrous skin,” Brain Research, vol. 734, no. 1-2, pp. 103–108, 1996. View at Publisher · View at Google Scholar · View at Scopus
  38. H. Z. Hu, Z. W. Li, and J. Q. Si, “Evidence for the existence of substance P autoreceptor in the membrane of rat dorsal root ganglion neurons,” Neuroscience, vol. 77, no. 2, pp. 535–541, 1997. View at Publisher · View at Google Scholar · View at Scopus
  39. G. Segond von Banchet, A. Pastor, C. Biskup, C. Schlegel, K. Benndorf, and H. G. Schaible, “Localization of functional calcitonin gene-related peptide binding sites in a subpopulation of cultured dorsal root ganglion neurons,” Neuroscience, vol. 110, no. 1, pp. 131–145, 2002. View at Publisher · View at Google Scholar · View at Scopus
  40. C. P. Carlsson, F. Sundler, and J. Wallengren, “Cutaneous innervation before and after one treatment period of acupuncture,” British Journal of Dermatology, vol. 155, no. 5, pp. 970–976, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  41. Y. M. Jan, T. C. Li, and C. L. Hsieh, “A Segmental effect involved in the changes of skin blood flow induced by acupuncture in normal health human,” The American Journal of Chinese Medicine, vol. 38, no. 3, pp. 441–448, 2010. View at Publisher · View at Google Scholar · View at Scopus
  42. H. Kashiba and Y. Ueda, “Acupuncture to the skin induces release of substance P and calcitonin gene-related peptide from peripheral terminals of primary sensory neurons in the rat,” The American Journal of Chinese Medicine, vol. 19, no. 3-4, pp. 189–197, 1991. View at Scopus
  43. L. Q. Cao and T. Wang, “The change of the concentration of substance P in the rats “channel” “point” skin and plasma in the acupuncture analgesia,” Zhen Ci Yan Jiu, vol. 14, no. 4, pp. 452–462, 1989. View at Scopus
  44. G. Jansen, T. Lundeberg, J. Kjartansson, and U. E. Samuelson, “Acupuncture and sensory neuropeptides increase cutaneous blood flow in rats,” Neuroscience Letters, vol. 97, no. 3, pp. 305–309, 1989. View at Scopus
  45. N. Erin and G. A. Clawson, “Parameters affecting substance P measurement in heart, lung, and skin,” BioTechniques, vol. 37, no. 2, pp. 232–239, 2004. View at Scopus
  46. N. Erin and O. Ulusoy, “Differentiation of neuronal from non-neuronal Substance P,” Regulatory Peptides, vol. 152, no. 1–3, pp. 108–113, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  47. R. Sekido, K. Ishimaru, and M. Sakita, “Differences of electroacupuncture-induced analgesic effect in normal and inflammatory conditions in rats,” The American Journal of Chinese Medicine, vol. 31, no. 6, pp. 955–965, 2003. View at Publisher · View at Google Scholar · View at Scopus
  48. G. G. Zhang, C. Yu, W. Lee, L. Lao, K. Ren, and B. M. Berman, “Involvement of peripheral opioid mechanisms in electroacupuncture analgesia,” Explore, vol. 1, no. 5, pp. 365–371, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  49. J. Y. Fan, Z. M. Wei, Z. Liu, et al., “Effect of catecholamines on the skin conductance in mice,” Journal of Beijing Medical University, vol. 25, pp. 324–326, 1993.
  50. S. X. Ma, “Enhanced nitric oxide concentrations and expression of nitric oxide synthase in acupuncture points/meridians,” The Journal of Alternative and Complementary Medicine, vol. 9, no. 2, pp. 207–215, 2003. View at Scopus
  51. V. Ogay, S. K. Min, J. S. Hyo, J. C. Cheon, and K. S. Soh, “Catecholamine-storing cells at acupuncture points of rabbits,” Journal of Acupuncture and Meridian Studies, vol. 1, no. 2, pp. 83–90, 2008. View at Publisher · View at Google Scholar · View at Scopus
  52. F. Wick, N. Wick, and M. C. Wick, “Morphological analysis of human acupuncture points through immunohistochemistry,” American Journal of Physical Medicine and Rehabilitation, vol. 86, no. 1, pp. 7–11, 2007. View at Publisher · View at Google Scholar · View at Scopus
  53. A. C. Ahn, R. Schnyer, L. Conboy, M. R. Laufer, and P. M. Wayne, “Electrodermal measures of jing-well points and their clinical relevance in endometriosis-related chronic pelvic pain,” Journal of Alternative and Complementary Medicine, vol. 15, no. 12, pp. 1293–1305, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  54. S. Knardahl, M. Elam, B. Olausson, and B. G. Wallin, “Sympathetic nerve activity after acupuncture in humans,” Pain, vol. 75, no. 1, pp. 19–25, 1998. View at Publisher · View at Google Scholar · View at Scopus
  55. C. C. Hsu, C. S. Weng, T. S. Liu, Y. S. Tsai, and Y. H. Chang, “Effects of electrical acupuncture on acupoint BL15 evaluated in terms of heart rate variability, pulse rate variability and skin conductance response,” The American Journal of Chinese Medicine, vol. 34, no. 1, pp. 23–36, 2006. View at Publisher · View at Google Scholar · View at Scopus
  56. C. S. Weng, Y. L. Hung, L. Y. Shyu, and Y. H. Chang, “A study of electrical conductance of meridian in the obese during weight reduction,” The American Journal of Chinese Medicine, vol. 32, no. 3, pp. 417–425, 2004. View at Publisher · View at Google Scholar · View at Scopus
  57. J. F. Zhang, B. Y. Deng, and S. Y. Su, “Analysis on the channel state in 45 patients with acute sport injury of external malleolus joint,” Zhen Ci Yan Jiu, vol. 32, no. 1, pp. 62–66, 2007. View at Scopus
  58. Q. Dong, X. Dong, D. Chen, H. Li, and S. Zhang, “The relation between acupuncture manipulations and responsive discharges of cutaneous receptors,” Zhen Ci Yan Jiu, vol. 17, no. 3, pp. 221–229, 1992. View at Scopus
  59. Q. Dong, X. Dong, D. Chen, H. Li, and M. Xian, “The relations between acupuncture manipulations and responsive discharges of deep receptors,” Zhen ci yan jiu = Acupuncture research / [Zhongguo yi xue ke xue yuan Yi xue qing bao yan jiu suo bian ji], vol. 18, no. 1, pp. 75–82, 1993. View at Scopus
  60. Q. Dong, X. Dong, H. Li, et al., “The influence of electroacupuncture on the activity of deep body receptors,” Shanghai Journal of Acupuncture, vol. 21, pp. 38–40, 2002.
  61. Q. Dong, X. Dong, H. Li, et al., “The influence of electroacupuncture on the activity of cutaneous receptors,” Journal of Sichuan of Traditional Chinese Medicine, vol. 20, pp. 9–11, 2002.
  62. X. Dong and Q. Dong, “The relations between acupuncture manipulations and types of afferent fibers,” Shanghai Journal of Acupuncture, vol. 8, pp. 23–27, 1988.
  63. Y. Zhao, W. C. Shi, and Z. L. Hou, “The effect of acupuncture manipulation to the discharges of needling sensation receptors,” Zhen Ci Yan Jiu, vol. 13, no. 3, pp. 221–225, 1988. View at Scopus
  64. H. M. Langevin, E. E. Konofagou, G. J. Badger et al., “Tissue displacements during acupuncture using ultrasound elastography techniques,” Ultrasound in Medicine and Biology, vol. 30, no. 9, pp. 1173–1183, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  65. G. Li, J. M. Liang, P. W. Li, et al., “Physiology and cell biology of acupuncture observed in calcium signaling activated by acoustic shear wave,” Pflügers Archiv, vol. 462, no. 4, pp. 587–597, 2011.
  66. F. Kagitani, S. Uchida, H. Hotta, and Y. Aikawa, “Manual acupuncture needle stimulation of the rat hindlimb activates groups I, II, III and IV single afferent nerve fibers in the dorsal spinal roots,” The Japanese Journal of Physiology, vol. 55, no. 3, pp. 149–155, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  67. C. Y. Chiang, C.T. Chang, H. L. Chu, et al., “Peripheral afferent pathway for acupuncture analgesia,” Scientia Sinica, vol. 16, pp. 210–217, 1973.
  68. H. Ohsawa, K. Okada, K. Nishijo, and Y. Sato, “Neural mechanism of depressor responses of arterial pressure elicited by acupuncture-like stimulation to a hindlimb in anesthetized rats,” Journal of the Autonomic Nervous System, vol. 51, no. 1, pp. 27–35, 1995. View at Publisher · View at Google Scholar · View at Scopus
  69. S. Uchida, M. Shimura, H. Ohsawa, and A. Suzuki, “Neural mechanism of bradycardiac responses elicited by acupuncture-like stimulation to a hind limb in anesthetized rats,” The Journal of Physiological Sciences, vol. 57, no. 6, pp. 377–382, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  70. A. Benham, G. Phillips, and M. I. Johnson, “An experimental study on the self-report of acupuncture needle sensation during deep needling with bi-directional rotation,” Acupuncture in Medicine, vol. 28, no. 1, pp. 16–20, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  71. B. Flaws and J. Lake, “Spirit-quieting, mind-stabilizing acupuncture points,” in Chinese Medical Psychiatry (A Textbook and Clinical Manual), chapter 5, pp. 63–65, Blue Poppy Press, New York, NY, USA, 2005.
  72. A. U. Asghar, G. Green, M. F. Lythgoe, G. Lewith, and H. MacPherson, “Acupuncture needling sensation: the neural correlates of deqi using fMRI,” Brain Research, vol. 1315, pp. 111–118, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  73. K. K. Hui, O. Marina, J. Liu, B. R. Rosen, and K. K. Kwong, “Acupuncture, the limbic system, and the anticorrelated networks of the brain,” Autonomic Neuroscience, vol. 157, no. 1-2, pp. 81–90, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  74. C. S. Yin, H. J. Park, S. Y. Kim et al., “Electroencephalogram changes according to the subjective acupuncture sensation,” Neurological Research, vol. 32, supplement 1, pp. S31–S36, 2010. View at Publisher · View at Google Scholar · View at Scopus
  75. P. White, P. Prescott, and G. Lewith, “Does needling sensation (de qi) affect treatment outcome in pain? Analysis of data from a larger single-blind, randomised controlled trial,” Acupuncture in Medicine, vol. 28, no. 3, pp. 120–125, 2010. View at Publisher · View at Google Scholar · View at Scopus
  76. A. Benham and M. I. Johnson, “Could acupuncture needle sensation be a predictor of analgesic response?” Acupuncture in Medicine, vol. 27, no. 2, pp. 65–67, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  77. T. C. Kuo, C. W. Lin, and F. M. Ho, “The soreness and numbness effect of acupuncture on skin blood flow,” The American Journal of Chinese Medicine, vol. 32, no. 1, pp. 117–129, 2004. View at Publisher · View at Google Scholar · View at Scopus
  78. M. Sandberg, T. Lundeberg, L. G. Lindberg, and B. Gerdle, “Effects of acupuncture on skin and muscle blood flow in healthy subjects,” European Journal of Applied Physiology, vol. 90, no. 1-2, pp. 114–119, 2003. View at Scopus
  79. J. Kong, D. T. Fufa, A. J. Gerber et al., “Psychophysical outcomes from a randomized pilot study of manual, electro, and sham acupuncture treatment on experimentally induced thermal pain,” The Journal of Pain, vol. 6, no. 1, pp. 55–64, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  80. K. M. Wang, S. M. Yao, Y. L. Xian, and Z. L. Hou, “A study on the receptive field of acupoints and the relationship between characteristics of needling sensation and groups of afferent fibres,” Scientia Sinica B, vol. 28, no. 9, pp. 963–971, 1985. View at Scopus
  81. K. Wang and J. Liu, “Needling sensation receptor of an acupoint supplied by the median nerve—studies of their electro-physiological characteristics,” The American Journal of Chinese Medicine, vol. 17, no. 3-4, pp. 145–156, 1989. View at Scopus
  82. H. Zonglian, “A study on the histologic structure of acupuncture points and types of fibers conveying needling sensation,” Chinese Medical Journal, vol. 92, no. 4, pp. 223–232, 1979. View at Scopus
  83. D. Bowsher, “Mechanisms of acupuncture,” in Medical Acupuncture: A Western Scientific Approach, J. Filshie and A. White, Eds., pp. 69–82, Churchill Livingstone, Edinburgh, UK, 1998.
  84. A. Skokljev and E. Koruga, “The role of trigeminal nerve in acupuncture,” Acupuncture and Electro-Therapeutics Research, vol. 13, no. 2-3, pp. 67–78, 1988. View at Scopus
  85. A. Li, Y. Wang, J. Xin et al., “Electroacupuncture suppresses hyperalgesia and spinal Fos expression by activating the descending inhibitory system,” Brain Research, vol. 1186, no. 1, pp. 171–179, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  86. G. van Wijk and D. S. Veldhuijzen, “Perspective on diffuse noxious inhibitory controls as a model of endogenous pain modulation in clinical pain syndromes,” The Journal of Pain, vol. 11, no. 5, pp. 408–419, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  87. K. J. Berkley and C. H. Hubscher, “Are there separate central nervous system pathways for touch and pain?” Nature Medicine, vol. 1, no. 8, pp. 766–773, 1995. View at Scopus
  88. S. X. Ma and X. Y. Li, “Increased neuronal nitric oxide synthase expression in the gracile nucleus of brainstem following electroacupuncture given between cutaneous hindlimb acupuncture points BL 64 & BL 65 in rats,” Acupuncture and Electro-Therapeutics Research, vol. 27, no. 3-4, pp. 157–169, 2002. View at Scopus
  89. F. Zhang, Y. Feng, R. Zhou, Y. Q. Zhang, and B. Y. Chen, “Observation on the central afferent pathway of “Guanyuan” (CV 4) under normal and pathological states and the influence of electroacupuncture,” Zhen Ci Yan Jiu, vol. 33, no. 3, pp. 147–153, 2008. View at Scopus
  90. S. Chen and S. X. Ma, “Nitric oxide in the gracile nucleus mediates depressor response to acupuncture (ST36),” Journal of Neurophysiology, vol. 90, no. 2, pp. 780–785, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  91. S. X. Ma, “Neurobiology of acupuncture: toward CAM,” Evidence-based Complementary and Alternative Medicine, vol. 1, no. 1, pp. 41–47, 2004. View at Scopus
  92. E. Urasaki, S. Wada, H. Yasukouchi, and A. Yokota, “Effect of transcutaneous electrical nerve stimulation (TENS) on central nervous system amplification of somatosensory input,” Journal of Neurology, vol. 245, no. 3, pp. 143–148, 1998. View at Publisher · View at Google Scholar · View at Scopus
  93. M. A. Arbab, T. Delgado, L. Wiklund, and N. A. Svendgaard, “Brain stem terminations of the trigeminal and upper spinal ganglia innervation of the cerebrovascular system: WGA-HRP transganglionic study,” Journal of Cerebral Blood Flow and Metabolism, vol. 8, no. 1, pp. 54–63, 1988. View at Scopus
  94. K. Kubota, N. Narita, K. Ohkubo et al., “Central projection of proprioceptive afferents arising from maxillo-facial regions in some animals studied by HRP-labeling technique,” Anatomischer Anzeiger, vol. 165, no. 2-3, pp. 229–251, 1988. View at Scopus
  95. S. L. Foote, F. E. Bloom, and G. Aston Jones, “Nucleus locus ceruleus: new evidence of anatomical and physiological specificity,” Physiological Reviews, vol. 63, no. 3, pp. 844–914, 1983. View at Scopus
  96. K. L. Simpson, D. W. Altman, L. Wang, M. L. Kirifides, R. C. S. Lin, and B. D. Waterhouse, “Lateralization and functional organization of the locus coeruleus projection to the trigeminal somatosensory pathway in rat,” The Journal of Comparative Neurology, vol. 385, no. 1, pp. 135–147, 1997. View at Scopus
  97. K. L. Simpson, B. D. Waterhouse, and R. C. Lin, “Origin, distribution, and morphology of galaninergic fibers in the rodent trigeminal system,” Journal of Comparative Neurology, vol. 411, no. 3, pp. 524–534, 1999. View at Scopus
  98. T. Takahashi, M. Shirasu, M. Shirasu et al., “The locus coeruleus projects to the mesencephalic trigeminal nucleus in rats,” Neuroscience Research, vol. 68, no. 2, pp. 103–106, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  99. J. M. Monti, “The structure of the dorsal raphe nucleus and its relevance to the regulation of sleep and wakefulness,” Sleep Medicine Reviews, vol. 14, no. 5, pp. 307–317, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  100. N. Singewald and A. Philippu, “Release of neurotransmitters in the locus coeruleus,” Progress in Neurobiology, vol. 56, no. 2, pp. 237–267, 1998. View at Publisher · View at Google Scholar · View at Scopus
  101. Z. Fang, “Expression of somatostatin mRNA and coexistence of SOM mRNA and 5-HT in nucleus raphe dorsalis following noxious stimulation and electroacupuncture analgesia,” Zhen Ci Yan Jiu, vol. 21, no. 3, pp. 22–26, 1996. View at Scopus
  102. Y. B. Kwon, M. S. Kang, S. S. Son et al., “Different frequencies of electroacupuncture modified the cellular activity of serotonergic neurons in brainstem,” The American Journal of Chinese Medicine, vol. 28, no. 3-4, pp. 435–441, 2000. View at Scopus
  103. Y. Kwon, M. Kang, C. Ahn, H. J. Han, B. C. Ahn, and J. H. Lee, “Effect of high or low frequency electroacupuncture on the cellular activity of catecholaminergic neurons in the brain stem,” Acupuncture and Electro-Therapeutics Research, vol. 25, no. 1, pp. 27–36, 2000. View at Scopus
  104. H. J. Lee, B. Lee, S. H. Choi et al., “Electroacupuncture reduces stress-induced expression of c-Fos in the brain of the rat,” The American Journal of Chinese Medicine, vol. 32, no. 5, pp. 795–806, 2004. View at Publisher · View at Google Scholar · View at Scopus
  105. H. J. Park, H. Y. Kim, D. H. Hahm, H. Lee, K. S. Kim, and I. Shim, “Electroacupuncture to ST36 ameliorates behavioral and biochemical responses to restraint stress in rats,” Neurological Research, vol. 32, supplement 1, pp. S111–S115, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  106. W. Tang, “Clinical observation on scalp acupuncture treatment in 50 cases of headache,” Journal of Traditional Chinese Medicine, vol. 22, no. 3, pp. 190–192, 2002. View at Scopus
  107. Z. J. Zhang, X. Y. Wang, Q. R. Tan, G. X. Jin, and S. M. Yao, “Electroacupuncture for refractory obsessive-compulsive disorder: a pilot waitlist-controlled trial,” Journal of Nervous and Mental Disease, vol. 197, no. 8, pp. 619–622, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  108. Y. Huang, W. Gong, J. Zou, et al., “An SCL-90 analysis of scalp electroacupuncture treatment of major depressive episode,” Shanghai Zhen Jiu Za Zhi, vol. 23, pp. 5–7, 2004.
  109. Y. Huang, J. Chen, and J. Zou, “Effect of scalp electro-acupuncture on post-stroke depression,” Zhong Guo Kang Fu, vol. 9, no. 40, pp. 172–173, 2005. View at Scopus
  110. Y. Huang, X. S. Lai, and A. W. Tang, “Comparative study of the specificities of needling acupoints DU20, DU26 and HT7 in intervening vascular dementia in different areas in the brain on the basis of scale assessment and cerebral functional imaging,” Chinese Journal of Integrative Medicine, vol. 13, no. 2, pp. 103–108, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  111. Z. J. Zhang, R. Ng, S. C. Man, et al., “Dense cranial electroacupuncture stimulation for major depressive disorder —a single-blind, randomized, controlled study,” Plos One, vol. 7, no. 1, Article ID e29651, 2012.
  112. R. P. Dhond, N. Kettner, and V. Napadow, “Neuroimaging acupuncture effects in the human brain,” Journal of Alternative and Complementary Medicine, vol. 13, no. 6, pp. 603–616, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  113. Z. H. Cho, S. C. Chung, J. P. Jones et al., “New findings of the correlation between acupoints and corresponding brain cortices using functional MRI,” Proceedings of the National Academy of Sciences of the United States of America, vol. 95, no. 5, pp. 2670–2673, 1998. View at Publisher · View at Google Scholar · View at Scopus
  114. G. Li, R. T. Cheung, Q. Y. Ma, and E. S. Yang, “Visual cortical activations on fMRI upon stimulation of the vision-implicated acupoints,” NeuroReport, vol. 14, no. 5, pp. 669–673, 2003. View at Publisher · View at Google Scholar · View at Scopus
  115. M. T. Wu, J. M. Sheen, K. H. Chuang et al., “Neuronal specificity of acupuncture response: a fMRI study with electroacupuncture,” NeuroImage, vol. 16, no. 4, pp. 1028–1037, 2002. View at Publisher · View at Google Scholar · View at Scopus
  116. F. Beissner and C. Henke, “Methodological problems in fMRI studies on acupuncture: a critical review with special emphasis on visual and auditory cortex activations,” Evidence-Based Complementary and Alternative Medicine, vol. 2011, Article ID 607637, 7 pages, 2011. View at Publisher · View at Google Scholar · View at PubMed
  117. Y. Chae, H. J. Park, D. H. Hahm et al., “fMRI review on brain responses to acupuncture: the limitations and possibilities in traditional Korean acupuncture,” Neurological Research, vol. 29, supplement 1, pp. S42–S48, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  118. Y. Chae, H. Lee, H. Kim, H. Sohn, J. H. Park, and H. J. Park, “The neural substrates of verum acupuncture compared to non-penetrating placebo needle: an fMRI study,” Neuroscience Letters, vol. 450, no. 2, pp. 80–84, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  119. R. P. Dhond, N. Kettner, and V. Napadow, “Do the neural correlates of acupuncture and placebo effects differ?” Pain, vol. 128, no. 1-2, pp. 8–12, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  120. J. L. Fang, T. Krings, J. Weidemann, I. G. Meister, and A. Thron, “Functional MRI in healthy subjects during acupuncture: different effects of needle rotation in real and false acupoints,” Neuroradiology, vol. 46, no. 5, pp. 359–362, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  121. B. J. Na, G. H. Jahng, S. U. Park et al., “An fMRI study of neuronal specificity of an acupoint: electroacupuncture stimulation of Yanglingquan (GB34) and its sham point,” Neuroscience Letters, vol. 464, no. 1, pp. 1–5, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  122. T. B. Parrish, A. Schaeffer, M. Catanese, et al., “Functional magnetic resonance imaging of real and sham acupuncture. Noninvasively measuring cortical activation from acupuncture,” IEEE Engineering in Medicine and Biology Magazine, vol. 24, no. 2, pp. 35–40, 2005.
  123. Y. Wu, Z. Jin, K. Li et al., “Functional magnetic resonance imaging activation of the brain in children: real acupoint versus sham acupoint,” Journal of Child Neurology, vol. 25, no. 7, pp. 849–855, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  124. B. Yan, K. Li, J. Xu et al., “Acupoint-specific fMRI patterns in human brain,” Neuroscience Letters, vol. 383, no. 3, pp. 236–240, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  125. S. Y. Cho, G. H. Jahng, S. U. Park, W. S. Jung, S. K. Moon, and J. M. Park, “FMRI study of effect on brain activity according to stimulation method at LI11, ST36: painful pressure and acupuncture stimulation of same acupoints,” Journal of Alternative and Complementary Medicine, vol. 16, no. 4, pp. 489–495, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  126. J. H. Zhang, X. D. Cao, J. Li, W. J. Tang, H. Q. Liu, and X. Y. Feng, “Neuronal specificity of needling acupoints at same meridian: a control functional magnetic resonance imaging study with electroacupuncture,” Acupuncture and Electro-Therapeutics Research, vol. 32, no. 3-4, pp. 179–193, 2007. View at Scopus
  127. K. Li, B. Shan, J. Xu et al., “Changes in fMRI in the human brain related to different durations of manual acupuncture needling,” Journal of Alternative and Complementary Medicine, vol. 12, no. 7, pp. 615–623, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  128. K. K. Hui, E. E. Nixon, M. G. Vangel et al., “Characterization of the “deqi” response in acupuncture,” BMC Complementary and Alternative Medicine, vol. 7, article 33, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  129. Z. H. Cho, S. C. Hwang, E. K. Wong et al., “Neural substrates, experimental evidences and functional hypothesis of acupuncture mechanisms,” Acta Neurologica Scandinavica, vol. 113, no. 6, pp. 370–377, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  130. J. S. Han, “Acupuncture: neuropeptide release produced by electrical stimulation of different frequencies,” Trends in Neurosciences, vol. 26, no. 1, pp. 17–22, 2003. View at Publisher · View at Google Scholar · View at Scopus
  131. Y. B. Kwon, M. S. Kang, S. S. Son et al., “Different frequencies of electroacupuncture modified the cellular activity of serotonergic neurons in brainstem,” The American Journal of Chinese Medicine, vol. 28, no. 3-4, pp. 435–441, 2000. View at Scopus
  132. Q. P. Ma, Y. Zhou, Y. X. Yu, and J. S. Han, “Electroacupuncture accelerated the expression of c-fos protooncogene in serotonergic neurons of nucleus raphe dorsalis,” International Journal of Neuroscience, vol. 67, no. 1–4, pp. 111–117, 1992. View at Scopus
  133. M. F. Levin and C. W. Hui-Chan, “Conventional and acupuncture-like transcutaneous electrical nerve stimulation excite similar afferent fibers,” Archives of Physical Medicine and Rehabilitation, vol. 74, no. 1, pp. 54–60, 1993. View at Scopus
  134. G. G. Xing, F. Y. Liu, X. X. Qu, J. S. Han, and Y. Wan, “Long-term synaptic plasticity in the spinal dorsal horn and its modulation by electroacupuncture in rats with neuropathic pain,” Experimental Neurology, vol. 208, no. 2, pp. 323–332, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  135. Z. Jin, W. T. Zhang, F. Luo et al., “Frequency-specific responses of human brain to peripheral transcutaneous electric nerve stimulation: a functional magnetic resonance imaging study,” Sheng Li Xue Bao, vol. 53, no. 4, pp. 275–280, 2001. View at Scopus
  136. W. T. Zhang, Z. Jin, G. H. Cui et al., “Relations between brain network activation and analgesic effect induced by low vs. high frequency electrical acupoint stimulation in different subjects: a functional magnetic resonance imaging study,” Brain Research, vol. 982, no. 2, pp. 168–178, 2003. View at Publisher · View at Google Scholar · View at Scopus
  137. H. F. Guo, J. Tian, X. Wang, Y. Fang, Y. Hou, and J. Han, “Brain substrates activated by electroacupuncture of different frequencies (I): comparative study on the expression of oncogene c-fos and genes coding for three opioid peptides,” Molecular Brain Research, vol. 43, no. 1-2, pp. 157–166, 1996. View at Publisher · View at Google Scholar · View at Scopus
  138. V. Napadow, N. Kettner, J. Liu et al., “Hypothalamus and amygdala response to acupuncture stimuli in carpal tunnel syndrome,” Pain, vol. 130, no. 3, pp. 254–266, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  139. A. B. Newberg, P. J. LaRiccia, B. Y. Lee, J. T. Farrar, L. Lee, and A. Alavi, “Cerebral blood flow effects of pain and acupuncture: a preliminary single-photon emission computed tomography imaging study,” Journal of Neuroimaging, vol. 15, no. 1, pp. 43–49, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  140. J. H. Zhang, J. Li, X. D. Cao, and X. Y. Feng, “Can electroacupuncture affect the sympathetic activity, estimated by skin temperature measurement? A functional MRI study on the effect of needling at GB 34 and GB 39 on patients with pain in the lower extremity,” Acupuncture & Electro-Therapeutics Research, vol. 34, no. 3-4, pp. 151–164, 2009. View at Scopus
  141. Y. Wu, Z. Jin, K. Li et al., “Effect of acupuncture on the brain in children with spastic cerebral palsy using functional neuroimaging (fMRI),” Journal of Child Neurology, vol. 23, no. 11, pp. 1267–1274, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  142. A. C. Chau, R. T. Fai Cheung, X. Jiang, P. K. M. Au-Yeung, and L. S. W. Li, “An fMRI study showing the effect of acupuncture in chronic stage stroke patients with aphasia,” Journal of Acupuncture and Meridian Studies, vol. 3, no. 1, pp. 53–57, 2010. View at Publisher · View at Google Scholar · View at Scopus
  143. J. D. Lee, J. S. Chon, H. K. Jeong et al., “The cerebrovascular response to traditional acupuncture after stroke,” Neuroradiology, vol. 45, no. 11, pp. 780–784, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  144. G. Li, C. R. Jack, and E. S. Yang, “An fMRI study of somatosensory-implicated acupuncture points in stable somatosensory stroke patients,” Journal of Magnetic Resonance Imaging, vol. 24, no. 5, pp. 1018–1024, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  145. J. D. Schaechter, B. D. Connell, W. B. Stason et al., “Correlated change in upper limb function and motor cortex activation after verum and sham acupuncture in patients with chronic stroke,” Journal of Alternative and Complementary Medicine, vol. 13, no. 5, pp. 527–532, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  146. Y. Chae, H. Lee, H. Kim et al., “Parsing brain activity associated with acupuncture treatment in Parkinson's diseases,” Movement Disorders, vol. 24, no. 12, pp. 1794–1802, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  147. Y. Zhou and J. Jia, “Effect of acupuncture given at the HT 7, ST 36, ST 40 and KI 3 acupoints on various parts of the brains of Alzheimer's disease patients,” Acupuncture and Electro-Therapeutics Research, vol. 33, no. 1-2, pp. 9–17, 2008. View at Scopus
  148. D. M. Duan, Y. Tu, L. P. Chen, and Z. J. Wu, “Study on electroacupuncture treatment of depression by magnetic resonance imaging,” Zhongguo Zhen Jiu, vol. 29, no. 2, pp. 139–144, 2009. View at Scopus
  149. Y. Huang, D. J. Li, A. W. Tang et al., “Effect of scalp acupuncture on glucose metabolism in brain of patients with depression,” Zhongguo Zhong Xi Yi Jie He Za Zhi, vol. 25, no. 2, pp. 119–122, 2005. View at Scopus
  150. S. Liu, W. Zhou, X. Ruan et al., “Activation of the hypothalamus characterizes the response to acupuncture stimulation in heroin addicts,” Neuroscience Letters, vol. 421, no. 3, pp. 203–208, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  151. V. F. Markelova, S. M. Zol'nikov, R. A. Belitskaia, T. P. Ponomarenko, and O. V. Shumova, “Changes in biogenic amine levels in the blood and urine during anesthesia using electroacupuncture,” Anesteziologiia i Reanimatologiia, no. 6, pp. 36–39, 1985. View at Scopus
  152. Y. Song, D. Zhou, J. Fan, H. Luo, and U. Halbreich, “Effects of electroacupuncture and fluoxetine on the density of GTP-binding-proteins in platelet membrane in patients with major depressive disorder,” Journal of Affective Disorders, vol. 98, no. 3, pp. 253–257, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  153. J. G. Dos Santos, F. Kawano, M. M. Nishida, Y. Yamamura, L. E. Mello, and A. Tabosa, “Antidepressive-like effects of electroacupuncture in rats,” Physiology & Behavior, vol. 93, no. 1-2, pp. 155–159, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  154. S. F. Xu, L. X. Zhuang, C. Z. Tang, and J. J. Yang, “Effects of acupuncture and embedding thread on central monoamine neurotransmitters in the depression model rat,” Zhongguo Zhen Jiu, vol. 27, no. 6, pp. 435–437, 2007. View at Scopus
  155. J. Yu, X. Y. Li, X. D. Cao, and G. C. Wu, “Sucrose preference is restored by electro-acupuncture combined with chlorimipramine in the depression-model rats,” Acupuncture and Electro-Therapeutics Research, vol. 31, no. 3-4, pp. 223–232, 2006. View at Scopus
  156. J. Yu, Q. Liu, Y. Q. Wang et al., “Electroacupuncture combined with clomipramine enhances antidepressant effect in rodents,” Neuroscience Letters, vol. 421, no. 1, pp. 5–9, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  157. C. M. Guimarães, M. C. Pinge, Y. Yamamura, and L. E. Mello, “Effects of acupuncture on behavioral, cardiovascular and hormonal responses in restraint-stressed Wistar rats,” Brazilian Journal of Medical and Biological Research, vol. 30, no. 12, pp. 1445–1450, 1997. View at Scopus
  158. K. Imai, H. Ariga, and T. Takahashi, “Electroacupuncture improves imbalance of autonomic function under restraint stress in conscious rats,” The American Journal of Chinese Medicine, vol. 37, no. 1, pp. 45–55, 2009. View at Scopus
  159. M. Iwa, Y. Nakade, T. N. Pappas, and T. Takahashi, “Electroacupuncture improves restraint stress-induced delay of gastric emptying via central glutaminergic pathways in conscious rats,” Neuroscience Letters, vol. 399, no. 1-2, pp. 6–10, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  160. B. Lee, I. Shim, H. J. Lee, Y. Yang, and D. H. Hahm, “Effects of acupuncture on chronic corticosterone-induced depression-like behavior and expression of neuropeptide Y in the rats,” Neuroscience Letters, vol. 453, no. 3, pp. 151–156, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  161. M. A. Medeiros, N. S. Canteras, D. Suchecki, and L. E. A. M. Mello, “c-Fos expression induced by electroacupuncture at the Zusanli point in rats submitted to repeated immobilization,” Brazilian Journal of Medical and Biological Research, vol. 36, no. 12, pp. 1673–1684, 2003. View at Scopus
  162. C. H. Yang, B. B. Lee, H. S. Jung, I. Shim, P. U. Roh, and G. T. Golden, “Effect of electroacupuncture on response to immobilization stress,” Pharmacology Biochemistry and Behavior, vol. 72, no. 4, pp. 847–855, 2002. View at Publisher · View at Google Scholar · View at Scopus
  163. S. J. Yun, H. J. Park, M. J. Yeom, D. H. Hahm, H. J. Lee, and E. H. Lee, “Effect of electroacupuncture on the stress-induced changes in brain-derived neurotrophic factor expression in rat hippocampus,” Neuroscience Letters, vol. 318, no. 2, pp. 85–88, 2002. View at Publisher · View at Google Scholar · View at Scopus
  164. H. J. Kim, H. J. Park, M. S. Hong et al., “Effect by acupuncture on hypothalamic expression of maternally separated rats: proteomic approach,” Neurological Research, vol. 32, supplement 1, pp. S69–S73, 2010. View at Publisher · View at Google Scholar · View at Scopus
  165. S. Lim, Y. H. Ryu, S. T. Kim, M. S. Hong, and H. J. Park, “Acupuncture increases neuropeptide Y expression in hippocampus of maternally-separated rats,” Neuroscience Letters, vol. 343, no. 1, pp. 49–52, 2003. View at Publisher · View at Google Scholar · View at Scopus
  166. H. J. Park, Y. Chae, J. Jang, I. Shim, H. Lee, and S. Lim, “The effect of acupuncture on anxiety and neuropeptide Y expression in the basolateral amygdala of maternally separated rats,” Neuroscience Letters, vol. 377, no. 3, pp. 179–184, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  167. H. Kim, H. J. Park, S. M. Han et al., “The effects of acupuncture stimulation at PC6 (Neiguan) on chronic mild stress-induced biochemical and behavioral responses,” Neuroscience Letters, vol. 460, no. 1, pp. 56–60, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  168. Q. Liu, J. Yu, W. L. Mi et al., “Electroacupuncture attenuates the decrease of hippocampal progenitor cell proliferation in the adult rats exposed to chronic unpredictable stress,” Life Sciences, vol. 81, no. 21-22, pp. 1489–1495, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  169. J. Wang, H. Zhao, Q. L. Mao-Ying, X. D. Cao, Y. Q. Wang, and G. C. Wu, “Electroacupuncture downregulates TLR2/4 and pro-inflammatory cytokine expression after surgical trauma stress without adrenal glands involvement,” Brain Research Bulletin, vol. 80, no. 1-2, pp. 89–94, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  170. J. P. Sun, H. T. Pei, X. L. Jin, L. Yin, Q. H. Tian, and S. J. Tian, “Effects of acupuncturing Tsusanli (ST36) on expression of nitric oxide synthase in hypothalamus and adrenal gland in rats with cold stress ulcer,” World Journal of Gastroenterology, vol. 11, no. 32, pp. 4962–4966, 2005. View at Scopus
  171. S. H. Han, S. H. Yoon, Y. W. Cho, C. J. Kim, and B. I. Min, “Inhibitory effects of electroacupuncture on stress responses evoked by tooth-pulp stimulation in rats,” Physiology and Behavior, vol. 66, no. 2, pp. 217–222, 1999. View at Publisher · View at Google Scholar · View at Scopus
  172. P. J. Rong, B. Zhu, Q. F. Huang, X. Y. Gao, H. Ben, and Y. H. Li, “Acupuncture inhibition on neuronal activity of spinal dorsal horn induced by noxious colorectal distension in rat,” World Journal of Gastroenterology, vol. 11, no. 7, pp. 1011–1017, 2005. View at Scopus
  173. J. Yin and J. D. Chen, “Gastrointestinal motility disorders and acupuncture,” Autonomic Neurosciencep, vol. 157, no. 1-2, pp. 31–37, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  174. T. Takahashi, “Acupuncture for functional gastrointestinal disorders,” Journal of Gastroenterology, vol. 41, no. 5, pp. 408–417, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  175. S. Lee, M. S. Lee, J. Y. Choi, S. W. Lee, S. Y. Jeong, and E. Ernst, “Acupuncture and heart rate variability: a systematic review,” Autonomic Neurosciencep, vol. 155, no. 1-2, pp. 5–13, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  176. P. Li and J. C. Longhurst, “Neural mechanism of electroacupuncture's hypotensive effects,” Autonomic Neuroscience, vol. 157, no. 1-2, pp. 24–30, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  177. L. H. Thomas, S. Cross, J. Barrett et al., “Treatment of urinary incontinence after stroke in adults,” Cochrane Database of Systematic Reviews, no. 1, Article ID CD004462, 2008. View at Scopus
  178. J. Martin, A. N. Donaldson, R. Villarroel, M. K. B. Parmar, E. Ernst, and I. J. Higginson, “Efficacy of acupuncture in asthma: systematic review and meta-analysis of published data from 11 randomised controlled trials,” The European Respiratory Journal, vol. 20, no. 4, pp. 846–852, 2002. View at Publisher · View at Google Scholar · View at Scopus
  179. F. Kagitani, S. Uchida, and H. Hotta, “Afferent nerve fibers and acupuncture,” Autonomic Neuroscience, vol. 157, no. 1-2, pp. 2–8, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  180. E. Noguchi, “Acupuncture regulates gut motility and secretion via nerve reflexes,” Autonomic Neuroscience, vol. 156, no. 1-2, pp. 15–18, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  181. V. A. Pavlov and K. J. Tracey, “Neural regulators of innate immune responses and inflammation,” Cellular and Molecular Life Sciences, vol. 61, no. 18, pp. 2322–2331, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  182. K. M. Buller, “Neuroimmune stress responses: reciprocal connections between the hypothalamus and the brainstem,” Stress, vol. 6, no. 1, pp. 11–17, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  183. I. Hickie and A. Lloyd, “Are cytokines associated with neuropsychiatric syndromes in humans?” International Journal of Immunopharmacology, vol. 17, no. 8, pp. 677–683, 1995. View at Publisher · View at Google Scholar · View at Scopus
  184. D. Kerr, C. Krishnan, M. L. Pucak, and J. Carmen, “The immune system and neuropsychiatric diseases,” International Review of Psychiatry, vol. 17, no. 6, pp. 443–449, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  185. A. H. Miller, V. Maletic, and C. L. Raison, “Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression,” Biological Psychiatry, vol. 65, no. 9, pp. 732–741, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  186. J. K. Kiecolt-Glaser, L. McGuire, T. F. Robles, and R. Glaser, “Psychoneuroimmunology and psychosomatic medicine: back to the future,” Psychosomatic Medicine, vol. 64, no. 1, pp. 15–28, 2002. View at Scopus
  187. M. M. Backonja, C. L. Coe, D. A. Muller, and K. Schell, “Altered cytokine levels in the blood and cerebrospinal fluid of chronic pain patients,” Journal of Neuroimmunology, vol. 195, no. 1-2, pp. 157–163, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  188. N. D. Brunetti, I. Munno, P. L. Pellegrino, et al., “Inflammatory cytokines imbalance in the very early phase of acute coronary syndrome: correlations with angiographic findings and in-hospital events,” Inflammation, vol. 34, no. 1, pp. 58–66, 2011.
  189. N. Uçeyler, M. Schäfers, and C. Sommer, “Mode of action of cytokines on nociceptive neurons,” Experimental Brain Research, vol. 196, no. 1, pp. 67–78, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  190. N. Uçeyler and C. Sommer, “Status of immune mediators in painful neuropathies,” Current Pain and Headache Reports, vol. 12, no. 3, pp. 159–164, 2008. View at Publisher · View at Google Scholar · View at Scopus
  191. D. Marazziti, F. Ambrogi, R. Vanacorea et al., “Immune cell imbalance in major depressive and panic disorders,” Neuropsychobiology, vol. 26, no. 1-2, pp. 23–26, 1992. View at Scopus
  192. C. Song, U. Halbreich, C. Han, B. E. Leonard, and H. Luo, “Imbalance between Pro- and Anti-inflammatory cytokines, and between Th1 and Th2 cytokines in depressed patients: the effect of electroacupuncture or fluoxetine treatment,” Pharmacopsychiatry, vol. 42, no. 5, pp. 182–188, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  193. B. E. Leonard, “The HPA and immune axes in stress: the involvement of the serotonergic system,” European Psychiatry, vol. 20, supplement 3, pp. S302–S306, 2005. View at Publisher · View at Google Scholar · View at Scopus
  194. L. Dyugovskaya, P. Lavie, and L. Lavie, “Lymphocyte activation as a possible measure of atherosclerotic risk in patients with sleep apnea,” Annals of the New York Academy of Sciences, vol. 1051, pp. 340–350, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  195. S. ThyagaRajan and D. L. Felten, “Modulation of neuroendocrine–immune signaling by L-deprenyl and L-desmethyldeprenyl in aging and mammary cancer,” Mechanisms of Ageing and Development, vol. 123, no. 8, pp. 1065–1079, 2002. View at Publisher · View at Google Scholar · View at Scopus
  196. Y. M. Liu, X. J. Liu, S. S. Bai et al., “The effect of electroacupuncture on T cell responses in rats with experimental autoimmune encephalitis,” Journal of Neuroimmunology, vol. 220, no. 1-2, pp. 25–33, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  197. K. Wang, H. Wu, G. Wang, M. Li, Z. Zhang, and G. Gu, “The effects of electroacupuncture on Th1/Th2 cytokine mRNA expression and mitogen-activated protein kinase signaling pathways in the splenic T cells of traumatized rats,” Anesthesia and Analgesia, vol. 109, no. 5, pp. 1666–1673, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  198. W. T. Zhang, Z. Jin, F. Luo, L. Zhang, Y. W. Zeng, and J. S. Han, “Evidence from brain imaging with fMRI supporting functional specificity of acupoints in humans,” Neuroscience Letters, vol. 354, no. 1, pp. 50–53, 2004. View at Publisher · View at Google Scholar · View at Scopus
  199. K. Streitberger and J. Kleinhenz, “Introducing a placebo needle into acupuncture research,” The Lancet, vol. 352, no. 9125, pp. 364–365, 1998. View at Publisher · View at Google Scholar · View at Scopus
  200. K. Linde, K. Niemann, A. Schneider, and K. Meissner, “How large are the nonspecific effects of acupuncture? A meta-analysis of randomized controlled trials,” BMC Medicine, vol. 8, article 75, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  201. Z. J. Zhang, H. Y. Chen, K. C. Yip, R. Ng, and V. T. Wong, “The effectiveness and safety of acupuncture therapy in depressive disorders: systematic review and meta-analysis,” Journal of Affective Disorders, vol. 124, no. 1-2, pp. 9–21, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  202. A. White, M. Cummings, P. Barlas et al., “Defining an adequate dose of acupuncture using a neurophysiological approach—a narrative review of the literature,” Acupuncture in Medicine, vol. 26, no. 2, pp. 111–120, 2008. View at Scopus
  203. S. M. Carlton and R. E. Coggeshall, “Immunohistochemical localization of 5-HT(2A) receptors in peripheral sensory axons in rat glabrous skin,” Brain Research, vol. 763, no. 2, pp. 271–275, 1997. View at Publisher · View at Google Scholar · View at Scopus
  204. H. Klapproth, T. Reinheimer, J. Metzen et al., “Non-neuronal acetylcholine, a signalling molecule synthezised by surface cells of rat and man,” Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 355, no. 4, pp. 515–523, 1997. View at Publisher · View at Google Scholar · View at Scopus
  205. K. Nordlind, O. Johansson, S. Lidén, and T. Hokfelt, “Glutamate- and aspartate-like immunoreactivities in human normal and inflamed skin,” Virchows Archiv B, vol. 64, no. 2, pp. 75–82, 1993. View at Scopus
  206. R. Nigam, H. El-Nour, B. Amatya, and K. Nordlind, “GABA and GABAA receptor expression on immune cells in psoriasis: a pathophysiological role,” Archives of Dermatological Research, vol. 302, no. 7, pp. 507–515, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  207. J. Woodcock, J. Witter, and R. A. Dionne, “Stimulating the development of mechanism-based, individualized pain therapies,” Nature Reviews: Drug Discovery, vol. 6, no. 9, pp. 703–710, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  208. S. Pain, C. Dezutter, C. Reymermier, B. Vogelgesang, E. Delay, and V. André, “Age-related changes in pro-opiomelanocortin (POMC) and related receptors in human epidermis,” International Journal of Cosmetic Science, vol. 32, no. 4, pp. 266–275, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  209. L. Bracci-Laudiero, L. Aloe, P. Buanne et al., “NGF modulates CGRP synthesis in human B-lymphocytes: a possible anti-inflammatory action of NGF?” Journal of Neuroimmunology, vol. 123, no. 1-2, pp. 58–65, 2002. View at Publisher · View at Google Scholar · View at Scopus
  210. A. B. Kay, “Calcitonin gene-related peptide- and vascular endothelial growth factor-positive inflammatory cells in late-phase allergic skin reactions in atopic subjects,” The Journal of Allergy and Clinical Immunology, vol. 127, no. 1, pp. 232–237, 2011. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  211. S. M. Carlton, J. Du, E. Davidson, S. Zhou, and R. E. Coggeshall, “Somatostatin receptors on peripheral primary afferent terminals: inhibition of sensitized nociceptors,” Pain, vol. 90, no. 3, pp. 233–244, 2001. View at Publisher · View at Google Scholar · View at Scopus
  212. S. M. Carlton, J. Du, S. Zhou, and R. E. Coggeshall, “Tonic control of peripheral cutaneous nociceptors by somatostatin receptors,” The Journal of Neuroscience, vol. 21, no. 11, pp. 4042–4049, 2001. View at Scopus
  213. M. Vockel, U. Breitenbach, H. J. Kreienkamp, et al., “Somatostatin regulates tight junction function and composition in human keratinocytes,” Experimental Dermatology, vol. 19, no. 10, pp. 888–894, 2010.
  214. N. T. Jou and S. X. Ma, “Responses of nitric oxide-cGMP release in acupuncture point to electroacupuncture in human skin in vivo using dermal microdialysis,” Microcirculation, vol. 16, no. 5, pp. 434–443, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  215. M. Tsuchiya, E. F. Sato, M. Inoue, and A. Asada, “Acupuncture enhances generation of nitric oxide and increases local circulation,” Anesthesia and Analgesia, vol. 104, no. 2, pp. 301–307, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  216. G. Burnstock, “Acupuncture: a novel hypothesis for the involvement of purinergic signalling,” Medical Hypotheses, vol. 73, no. 4, pp. 470–472, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  217. A. Dray and M. Perkins, “Bradykinin and inflammatory pain,” Trends in Neurosciences, vol. 16, no. 3, pp. 99–104, 1993. View at Publisher · View at Google Scholar · View at Scopus
  218. A. Dray, “Inflammatory mediators of pain,” British Journal of Anaesthesia, vol. 75, no. 2, pp. 125–131, 1995. View at Scopus
  219. B. R. Conklin, R. M. Burch, L. R. Steranka, and J. Axelrod, “Distinct bradykinin receptors mediate stimulation of prostaglandin synthesis by endothelial cells and fibroblasts,” The Journal of Pharmacology and Experimental Therapeutics, vol. 244, no. 2, pp. 646–649, 1988. View at Scopus
  220. M. D. Southall, T. Li, L. S. Gharibova, Y. Pei, G. D. Nicol, and J. B. Travers, “Activation of epidermal vanilloid receptor-1 induces release of proinflammatory mediators in human keratinocytes,” The Journal of Pharmacology and Experimental Therapeutics, vol. 304, no. 1, pp. 217–222, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  221. X. M. Wang, M. Hamza, T. X. Wu, and R. A. Dionne, “Upregulation of IL-6, IL-8 and CCL2 gene expression after acute inflammation: correlation to clinical pain,” Pain, vol. 142, no. 3, pp. 275–283, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  222. M. J. Song, Y. Q. Wang, and G. C. Wu, “Additive anti-hyperalgesia of electroacupuncture and intrathecal antisense oligodeoxynucleotide to interleukin-1 receptor type I on carrageenan-induced inflammatory pain in rats,” Brain Research Bulletin, vol. 78, no. 6, pp. 335–341, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  223. W. Ma and J. C. Eisenach, “Morphological and pharmacological evidence for the role of peripheral prostaglandins in the pathogenesis of neuropathic pain,” European Journal of Neuroscience, vol. 15, no. 6, pp. 1037–1047, 2002. View at Publisher · View at Google Scholar · View at Scopus
  224. S. H. Zhang, Q. X. Sun, Z. Seltzer et al., “Paracrine-like excitation of low-threshold mechanoceptive C-fibers innervating rat hairy skin is mediated by substance P via NK-1 receptors,” Brain Research Bulletin, vol. 75, no. 1, pp. 138–145, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  225. H. S. Amonoo Kuofi, “The density of muscle spindles in the medial, intermediate and lateral columns of human intrinsic postvertebral muscles,” Journal of Anatomy, vol. 136, no. 3, pp. 509–519, 1983. View at Scopus
  226. I. Darian-Smith and P. Kenins, “Innervation density of mechanoreceptive fibres supplying glabrous skin of the monkey's index finger,” The Journal of Physiology, vol. 309, pp. 147–155, 1980. View at Scopus