In Vitro Assessment of Cytochrome P450 2C19 Potential of Naoxintong

Table 3

Comparison of the amount of 4′-OH-mephenytoin among blank group, positive control group, and trial group.

	Blank group (𝑛=5)	Positive control group (phenytoin sodium, 𝑛=5)	Trial group (BNC, 𝑛=5)
Incubation final concentration (μg/mL)		0.3	5	50	100	150	200	250
4′-OH-M (nmol/mg·h)	6.8±0.3	7.7±0.3	6.6±0.4	6.8±0.3	7.1±0.3	7.3±0.4	7.5±0.3	7.6±0.2
		▲▲▲				▲▲,△△,♀	▲▲,△△△,♀♀,†	▲▲▲,△△△,♀♀♀,††

Note: values are presented as mean ± SD.
▲▲▲, △△△, ♀♀♀: compared with blank, 5 μg/mL, 50 μg/mL, 100 μg/mL, respectively, 𝑃<0.000.
▲▲, △△, ♀♀, ††: compared with blank, 5 μg/mL, 50 μg/mL, 100 μg/mL, respectively, 𝑃<0.001.
♀, †: compared with 5 μg/mL, 50 μg/mL, respectively, 𝑃<0.05.