Efficacy and Safety of a Chinese Herbal Medicine Formula (RCM-104) in the Management of Simple Obesity: A Randomized, Placebo-Controlled Clinical Trial

Table 4

Changes in anthropometric parameters of RCM-104 and placebo groups.

	Study period	RCM-104 (𝑛=50) value ± SD	Placebo (𝑛=42) value ± SD	𝑃 value**
Body weight (kg)	Baseline	99.5±15.1	98.2±17.3
	Final	98.0±15.4	98.7±17.5
	𝑃 value*	0.002	0.510	0.006
Body mass index (kg/m^2)	Baseline	35.9±4.9	35.9±5.9
	Final	35.3±5.7	36.1±5.9
	𝑃 value*	0.008	0.676	0.027
Body fat (%)	Baseline	42.2±9.2	42.9±8.4
	Final	41.3±9.2	43.0±7.8
	𝑃 value*	0.104	0.935	0.151
Waist circumference (cm)	Baseline	108.5±12.3	107.4±11.04
	Final	106.6±12.5	106.3±12.3
	𝑃 value*	0.014	0.182	0.445
Hip circumference (cm)	Baseline	124.4±12.3	124.7±12.5
	Final	122.9±12.0	125.1±12.8
	𝑃 value*	0.034	0.544	0.042
Waist to Hip Ratio	Baseline	0.87±0.08	0.87±0.08
	Final	0.87±0.07	0.85±0.081
	𝑃 value*	0.382	0.067	0.356
Systolic Blood pressure (mmHg)	Baseline	122.8±14.1	126.2±16.8
	Final	117.8±14.0	118.3±15.6
	𝑃 value*	0.738	0.854	0.685
Diastolic blood pressure (mmHg)	Baseline	80.8±9.9	82.9±11.7
	Final	81.1±9.8	81.8±10.4
	𝑃 value*	0.853	0.855	0.934
Heart rate (beats/min)	Baseline	72.6±8.5	73.1±9.7
	Final	74.6±9.2	73.2±9.1
	𝑃 value*	0.084	0.897	0.281
RMR (Kcal/day)	Baseline	1353.8±353	1333.3±315
	Final	1478.9±330	1450.6±276
	𝑃 value*	0.085	0.019	0.827

*Comparison within the group between baseline and final visits.
**Comparison between groups at the end of trial.
(ANCOVA, using baselines as covariate). Body Weight, Body Mass Index, and Body Fat were used as a single family of variables when assessing significance using Hochberg’s Step-up procedure for adjusting significance levels as these variables were the focus of the study.