436139.fig.002a
(a)
436139.fig.002b
(b)
436139.fig.002c
(c)
436139.fig.002d
(d)
436139.fig.002e
(e)
Figure 2: Photomicroscopy of liver sections from CCl4-intoxicated rats (10x). Histological observations of the liver tissue of the normal animals showed hepatic cells with well-preserved cytoplasm, nucleus, nucleolus, and central vein (a). Treatment with CCl4 caused fatty degeneration with severe necrosis of the parenchyma cells in the central lobular region of the liver. Furthermore, hepatocytic necrosis was predominant surrounding the central vein, which formed a streak-like appearance (b), (c), (d), and (e) showed animals treated with EECS (200 and 400 mg/kg, p.o.) and silymarin (25 mg/kg) and restored the altered histopathological changes, respectively.