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Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 438460, 11 pages
NMDA Receptor-Dependent Synaptic Activity in Dorsal Motor Nucleus of Vagus Mediates the Enhancement of Gastric Motility by Stimulating ST36
1Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, 16 Nanxiaojie Street, Dongzhimennei, Beijing 100700, China
2Qingdao Haici Medical Group, 4 Renmin Road, Qingdao 266033, China
3Guanganmen Hospitals, China Academy of Chinese Medical Science, Beijing 100053, China
4The Affiliated Hospital, Shandong University of Traditional Chinese Medicine, Jinan 250014, China
5Department of Pharmacology, Southern Medical University, Guangzhou 510515, China
6Department of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, FL 32306, USA
Received 12 July 2012; Revised 4 September 2012; Accepted 8 September 2012
Academic Editor: Ying Xia
Copyright © 2012 Xinyan Gao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- X. Lin, J. Liang, J. Ren, F. Mu, M. Zhang, and J. D. Chen, “Electrical stimulation of acupuncture points enhances gastric myoelectrical activity in humans,” American Journal of Gastroenterology, vol. 92, no. 9, pp. 1527–1530, 1997.
- C. S. Chang, C. W. Ko, C. Y. Wu, and G. H. Chen, “Effect of electrical stimulation on acupuncture points in diabetic patients with gastric dysrhythmia: a pilot study,” Digestion, vol. 64, no. 3, pp. 184–190, 2001.
- H. Ouyang and J. D. Z. Chen, “Review article: therapeutic roles of acupuncture in functional gastrointestinal disorders,” Alimentary Pharmacology and Therapeutics, vol. 20, no. 8, pp. 831–841, 2004.
- T. Takahashi, “Acupuncture for functional gastrointestinal disorders,” Journal of Gastroenterology, vol. 41, no. 5, pp. 408–417, 2006.
- J. Yin and J. D. Z. Chen, “Gastrointestinal motility disorders and acupuncture,” Autonomic Neuroscience, vol. 157, no. 1-2, pp. 31–37, 2010.
- Y. Li, G. Tougas, S. G. Chiverton, and R. H. Hunt, “The effect of acupuncture on gastrointestinal function and disorders,” American Journal of Gastroenterology, vol. 87, no. 10, pp. 1372–1381, 1992.
- G. Lux, J. Hagel, P. Bäcker et al., “Acupuncture inhibits vagal gastric acid secretion stimulated by sham feeding in healthy subjects,” Gut, vol. 35, no. 8, pp. 1026–1029, 1994.
- H. Ouyang, J. Yin, Z. Wang, P. J. Pasricha, and J. D. Z. Chen, “Electroacupuncture accelerates gastric emptying in association with changes in vagal activity,” American Journal of Physiology, vol. 282, no. 2, pp. G390–G396, 2002.
- M. Tatewaki, M. Harris, K. Uemura et al., “Dual effects of acupuncture on gastric motility in conscious rats,” American Journal of Physiology, vol. 285, no. 4, pp. R862–R872, 2003.
- J. Chen, G. Q. Song, J. Yin, T. Koothan, and J. D. Z. Chen, “Electroacupuncture improves impaired gastric motility and slow waves induced by rectal distension in dogs,” American Journal of Physiology, vol. 295, no. 3, pp. G614–G620, 2008.
- K. N. Browning, W. E. Renehan, and R. A. Travagli, “Electrophysiological and morphological heterogeneity of rat dorsal vagal neurones which project to specific areas of the gastrointestinal tract,” Journal of Physiology, vol. 517, Part 2, pp. 521–532, 1999.
- R. A. Gillis, J. A. Quest, F. D. Pagani, et al., “Control centers in the central nervous system for regulating gastrointestinal motility,” in Comprehensive Physiology, R. Terjung, Ed., pp. 621–683, Wiley Online Library, 2011.
- R. A. Travagli, G. E. Hermann, K. N. Browning, and R. C. Rogers, “Brainstem circuits regulating gastric function,” Annual Review of Physiology, vol. 68, pp. 279–305, 2006.
- H. Gao and B. N. Smith, “Tonic GABAa receptor-mediated inhibition in the rat dorsal motor nucleus of the vagus,” Journal of Neurophysiology, vol. 103, no. 2, pp. 904–914, 2010.
- H. E. Raybould, L. J. Jakobsen, D. Novin, and Y. Tache, “TRH stimulation and L-glutamic acid inhibition of proximal gastric motor activity in the rat dorsal vagal complex,” Brain Research, vol. 495, no. 2, pp. 319–328, 1989.
- H. S. Feng, R. B. Lynn, J. Han, and F. P. Brooks, “Gastric effects of TRH analogue and bicuculline injected into dorsal motor vagal nucleus in cats,” American Journal of Physiology, vol. 259, no. 2, pp. G321–G326, 1990.
- R. A. Travagli, R. A. Gillis, and S. Vicini, “Effects of thyrotropin-releasing hormone on neurons in rat dorsal motor nucleus of the vagus, in vitro,” American Journal of Physiology, vol. 263, no. 4, pp. G508–G517, 1992.
- R. J. Washabau, M. Fudge, W. J. Price, and F. C. Barone, “GABA receptors in the dorsal motor nucleus of the vagus influence feline lower esophageal sphincter and gastric function,” Brain Research Bulletin, vol. 38, no. 6, pp. 587–594, 1995.
- Y. Q. Li, B. Zhu, P. J. Rong, H. Ben, and Y. H. Li, “Neural mechanism of acupuncture-modulated gastric motility,” World Journal of Gastroenterology, vol. 13, no. 5, pp. 709–716, 2007.
- X. Y. Gao, S. P. Zhang, B. Zhu, and H. Q. Zhang, “Investigation of specificity of auricular acupuncture points in regulation of autonomic function in anesthetized rats,” Autonomic Neuroscience, vol. 138, no. 1-2, pp. 50–56, 2008.
- S. Cheng, Chinese Acupuncture and Moxibustion, Foreign Language Press, Beijing, China, 1996.
- K. N. Browning, A. E. Kalyuzhny, and R. A. Travagli, “μ-opioid receptor trafficking on inhibitory synapses in the rat brainstem,” Journal of Neuroscience, vol. 24, no. 33, pp. 7344–7352, 2004.
- Z. K. Krowicki, K. A. Sharkey, S. C. Serron, N. A. Nathan, and P. J. Hornby, “Distribution of nitric oxide synthase in rat dorsal vagal complex and effects of microinjection of nitric oxide compounds upon gastric motor function,” The Journal of Comparative Neurology, vol. 377, pp. 49–69, 1997.
- R. C. Rogers, G. E. Hermann, and R. A. Travagli, “Brainstem pathways responsible for oesophageal control of gastric motility and tone in the rat,” Journal of Physiology, vol. 514, no. 2, pp. 369–383, 1999.
- P. J. Hornby, “Receptors and transmission in the brain-gut axis. II. Excitatory amino acid receptors in the brain-gut axis,” American Journal of Physiology, vol. 280, no. 6, pp. G1055–G1060, 2001.
- X. Zhang and R. Fogel, “Glutamate mediates an excitatory influence of the paraventricular hypothalamic nucleus on the dorsal motor nucleus of the vagus,” Journal of Neurophysiology, vol. 88, no. 1, pp. 49–63, 2002.
- K. N. Browning and R. A. Travagli, “The peptide TPH uncovers the presence of presynaptic 5-HT1A receptors via activation of a second messenger pathway in the rat dorsal vagal complex,” Journal of Physiology, vol. 531, no. 2, pp. 425–435, 2001.
- K. N. Browning, A. E. Kalyuzhny, and R. A. Travagli, “Opioid peptides inhibit excitatory but not inhibitory synaptic transmission in the rat dorsal motor nucleus of the vagus,” Journal of Neuroscience, vol. 22, no. 8, pp. 2998–3004, 2002.
- Y. Liu, T. P. Wong, M. Aarts et al., “NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo,” Journal of Neuroscience, vol. 27, no. 11, pp. 2846–2857, 2007.
- V. Mutel, D. Buchy, A. Klingelschmidt et al., “In vitro binding properties in rat brain of [3H] Ro 25-6981, a potent and selective antagonist of NMDA receptors containing NR2B subunits,” Journal of Neurochemistry, vol. 70, no. 5, pp. 2147–2155, 1998.
- A. Sato, Y. Sato, A. Suzuki, and S. Uchida, “Neural mechanisms of the reflex inhibition and excitation of gastric motility elicited by acupuncture-like stimulation in anesthetized rats,” Neuroscience Research, vol. 18, no. 1, pp. 53–62, 1993.
- E. Noguchi, “Acupuncture regulates gut motility and secretion via nerve reflexes,” Autonomic Neuroscience, vol. 156, no. 1-2, pp. 15–18, 2010.
- A. Willis, M. Mihalevich, R. A. Neff, and D. Mendelowitz, “Three types of postsynaptic glutamatergic receptors are activated in DMNX neurons upon stimulation of NTS,” American Journal of Physiology, vol. 271, no. 6, pp. R1614–R1619, 1996.
- D. L. Broussard, H. Li, and S. M. Altschuler, “Colocalization of GABA(A) and NMDA receptors within the dorsal motor nucleus of the vagus nerve (DMV) of the rat,” Brain Research, vol. 763, no. 1, pp. 123–126, 1997.
- M. Tatewaki, M. Harris, K. Uemura et al., “The stimulatory effects of acupuncture on gastric motility is mediated via vagal cholinergic and opioid pathways in conscious rats,” Gastroenterology, vol. 124, Supplement 1, pp. A669–A670, 2003.
- H. Monyer, R. Sprengel, R. Schoepfer et al., “Heteromeric NMDA receptors: molecular and functional distinction of subtypes,” Science, vol. 256, no. 5060, pp. 1217–1221, 1992.
- J. Nabekura, T. Ueno, S. Katsurabayashi, A. Furuta, N. Akaike, and M. Okada, “Reduced NR2A expression and prolonged decay of NMDA receptor-mediated synaptic current in rat vagal motoneurons following axotomy,” Journal of Physiology, vol. 539, no. 3, pp. 735–741, 2002.
- S. Vicini, J. F. Wang, J. H. Li et al., “Functional and pharmacological differences between recombinant N- methyl-D-aspartate receptors,” Journal of Neurophysiology, vol. 79, no. 2, pp. 555–566, 1998.