Ecklonia cava Inhibits Glucose Absorption and Stimulates Insulin Secretion in Streptozotocin-Induced Diabetic Mice

Figure 1

Effects of Ecklonia cava (EC) on Na⁺-dependent glucose uptake and SGLT1 expression. (a) Time course effects. *Effect of EC (100 μg/mL) at 𝑃<0.05. (b) Concentration-dependent inhibitory effects. Data are expressed as the % of inhibitory activity compared to control group. Glucose uptake was measured with 150 mM NaCl or 300 μM phlorizin to evaluate the sodium dependency of the glucose uptake. (c) Downregulation of SGLT1 expression by EC treatment. SGLT1 abundance was determined by ELISA analysis. a-cDifferent letters are significantly different at 𝑃<0.05. Each value is the mean ± SE of three different experiments.

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